{"id":13423,"date":"2024-08-22T23:50:23","date_gmt":"2024-08-22T21:50:23","guid":{"rendered":"https:\/\/valintermed.com\/?p=13423"},"modified":"2024-08-22T23:50:23","modified_gmt":"2024-08-22T21:50:23","slug":"tyazhelyy-kombinirovannyy-immunodefitsit-svyazannyy-s-zap70","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/tyazhely-combined-immunodeficiency-linked-to-zap70\/","title":{"rendered":"ZAP70-associated severe combined immunodeficiency"},"content":{"rendered":"
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ZAP70-associated severe combined immunodeficiency is a rare genetic disorder characterized by impaired immune system function. The condition causes significant susceptibility to infections, both bacterial and viral, and can manifest itself in early childhood. ZAP70 (Zeta-chain-associated protein kinase 70) is an important signaling element in T cells responsible for the cellular immune response. The presence of mutations in the ZAP70 gene leads to T-cell dysfunction and severe immune disorders, which necessitates early diagnosis and comprehensive treatment of this condition.<\/p>\n

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