{"id":13413,"date":"2024-08-22T23:59:57","date_gmt":"2024-08-22T21:59:57","guid":{"rendered":"https:\/\/valintermed.com\/?p=13413"},"modified":"2024-08-22T23:59:57","modified_gmt":"2024-08-22T21:59:57","slug":"sindromy-opuholi-vilmsa-svyazannye-s-wt1","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/syndromes-of-tumors-of-the-vilmsa-associated-with-wt1\/","title":{"rendered":"Wilms tumor syndromes associated with WT1"},"content":{"rendered":"
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Wilms tumor syndromes (Wilms syndrome) are rare malignant neoplasms of the kidneys, characterized by tumor formation against the background of various genetic disorders. This type of tumor is most often found in children, especially between the ages of 2 and 5 years, and accounts for almost 5% of all cases of childhood cancer. The association of Wilms tumor syndromes with the WT1 gene (Wilms Tumor 1) is key to understanding the pathogenesis of the disease. The WT1 gene is located on chromosome 11p13 and plays an important role in the development of the kidneys and other organs, including the gonads. Mutations in this gene are associated with the development of Wilms tumor, as well as with several hereditary syndromes, such as Williams syndrome and Down syndrome.<\/p>\n

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