{"id":13360,"date":"2024-08-23T00:52:49","date_gmt":"2024-08-22T22:52:49","guid":{"rendered":"https:\/\/valintermed.com\/?p=13360"},"modified":"2024-08-23T00:52:49","modified_gmt":"2024-08-22T22:52:49","slug":"opuhol-vilmsa","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/","title":{"rendered":"Wilms tumor"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Wilms tumor, or nephroblastoma, is a malignant tumor of the kidneys, mainly detected in children. This disease is well known for its rapidly progressive course and is usually diagnosed between the ages of 2 and 5. The tumor arises from immature kidney cells and can be associated with various developmental anomalies. In the early stages, the tumor may be asymptomatic, but as it grows in size, it can manifest itself through an enlarged abdomen, pain in the kidney area, as well as various systemic symptoms, such as anemia and loss of appetite. Despite its aggressive characteristics, high patient survival is achieved thanks to modern diagnostic and treatment methods, which makes Wilms tumor a relevant topic in pediatric oncology.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/vilmsa-tumor\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Wilms&#039; tumor was first described in 1814 by the German surgeon Rudolf Wilms. However, until the 20th century, the disease remained poorly studied, which made it difficult to diagnose and treat. Since the mid-20th century, active research began, which made it possible to identify the tumor as a separate clinical diagnosis. In the late 1960s, a new treatment regimen was developed that included chemotherapy and surgery, which led to a significant improvement in survival. An interesting fact is that a female pediatrician, whose work was devoted to studying the tumor, was diagnosed with a similar case in her personal practice, which gave rise to new, more systematic approaches to the study and treatment of this tumor in children.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nephroblastoma accounts for approximately 5-7% of all childhood cancer cases. The disease is most common in children aged 2 to 5 years, with the greatest number of cases occurring in children aged 3-4 years. According to statistics, the incidence among boys is slightly higher than among girls, with a ratio of approximately 1.5:1. Globally, the incidence of nephroblastoma varies from 1 to 10 cases per 100,000 population, depending on the region. Thus, regions with a high level of medical care and cancer monitoring have higher detection rates, while in developing countries the incidence may be lower, but this is due to insufficient diagnostics.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Although most cases of Wilms&#039; tumor are considered sporadic, there are a number of known genetic syndromes associated with an increased susceptibility to the disease. These patients have mutations in genes responsible for kidney development. The major genes involved include:<\/p>\n<ul>\n<li>WT1 \u2013 associated with Wilms syndrome and genital malformations.<\/li>\n<li>WTX \u2013 includes changes associated with insufficiency in the regulation of other oncogenes.<\/li>\n<li>CTNNB1 \u2013 mutations in this gene lead to the activation of signaling pathways that promote tumor growth.<\/li>\n<\/ul>\n<p>Individuals with a family history of the tumor or syndromes such as Burner syndrome and Down syndrome also have an increased risk of developing nephroblastoma. Molecular studies are ongoing to identify additional genetic markers associated with the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are various risk factors that contribute to the development of Wilms&#039; tumor. They can be both genetic and environmental. The most important factors are:<\/p>\n<ul>\n<li>The presence of conditions associated with abnormalities of the kidneys or other organs.<\/li>\n<li>Exposure to environmental carcinogens such as drugs and chemicals when a pregnant woman comes into contact with them.<\/li>\n<li>Climate factors such as radiation, which can increase the risk.<\/li>\n<li>History of other types of tumors in childhood.<\/li>\n<\/ul>\n<p>Also, events occurring during pregnancy may be related to changes in genetics and metabolism, which, in turn, leads to an increased risk of tumor development in newborns.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of nephroblastoma requires a comprehensive examination. The main symptoms indicating the possible development of a tumor may include:<\/p>\n<ul>\n<li>Enlargement of the abdomen, especially in the area of one of the kidneys.<\/li>\n<li>Pain in the abdomen and lower back.<\/li>\n<li>Anemia, weight loss and loss of appetite.<\/li>\n<\/ul>\n<p>Laboratory tests may include a complete blood count and biochemistry profile to check for anemia, changes in enzyme levels, and other indicators. Radiological studies such as ultrasound and CT are key in visualizing the tumor and determining its size and location. Since the tumor can mimic other kidney pathologies, the differential diagnosis includes conditions such as:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Pyelonephritis.<\/li>\n<li>Kidney cancer.<\/li>\n<li>Kidney cysts.<\/li>\n<\/ul>\n<p>Each of these conditions requires a separate approach to diagnosis and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for Wilms tumor depends on the stage of the disease, the size of the tumor, and the patient&#039;s overall condition. The main approaches to therapy include:<\/p>\n<ul>\n<li>Surgical intervention to remove the tumor, which can be performed as either resection of the affected kidney or nephrectomy.<\/li>\n<li>Pharmacological treatments, including vincristine- and dacarbazine-based chemotherapy, are given both before and after surgery to shrink the tumor and reduce the chance of recurrence.<\/li>\n<li>Radiation therapy is often used in cases of recurrence or inoperable tumors.<\/li>\n<li>Immunotherapy as new treatment approaches in a series of clinical trials.<\/li>\n<\/ul>\n<p>It is important to note that individualization of treatment taking into account the patient&#039;s genetic background also influences the choice of therapeutic strategy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat Wilms tumor include:<\/p>\n<ul>\n<li>Vincristine.<\/li>\n<li>Dacarbazine.<\/li>\n<li>Etamustine.<\/li>\n<li>Topotecan.<\/li>\n<li>Doxorubicin.<\/li>\n<\/ul>\n<p>These drugs can be used both in monotherapy and in combination regimens depending on the stage of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with nephroblastoma includes regular examinations and scans to detect possible recurrences. Control diagnostic stages are usually performed every 3-6 months for the first two years after completion of treatment, and then may be extended. The prognosis is positive in most cases, especially in case of early detection and adequate treatment, as evidenced by high survival rates reaching 85-90% at stage I. However, complications such as relapse of the disease and development of secondary tumors after chemotherapy are possible, which requires special monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The course of Wilms&#039; tumor has its own characteristics depending on the age group. In younger children, the tumor is usually diagnosed in a more aggressive form, and, as a rule, is treated more actively. In adolescents, nephroblastoma is less common, but often has a more malignant nature. It is important that the approach to diagnosis and treatment takes into account the patient&#039;s age, physiological characteristics and health status.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is Wilms tumor?<\/strong><br \/>\nWilms tumor, or nephroblastoma, is a malignant kidney tumor that is mainly diagnosed in children aged 2-5 years.<\/li>\n<li><strong>What are the main symptoms of Wilms tumor?<\/strong><br \/>\nThe main symptoms include abdominal distension, pain in the kidney area, anemia and loss of appetite.<\/li>\n<li><strong>How is the disease diagnosed?<\/strong><br \/>\nDiagnosis includes laboratory tests, radiological examinations such as ultrasound and CT, and differential diagnosis with other kidney diseases.<\/li>\n<li><strong>What treatments are used for Wilms tumor?<\/strong><br \/>\nTreatment includes surgery, chemotherapy and radiation therapy, as well as immunotherapy in promising regimens.<\/li>\n<li><strong>What is the prognosis for Wilms tumor?<\/strong><br \/>\nThe prognosis is positive in most cases, especially at stage I, with survival rates up to 90% with timely treatment.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Wilms tumor, or nephroblastoma, is a malignant tumor of the kidneys, primarily found in children. This disease is well known for its rapidly progressive course.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13360","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13360","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13360"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13360\/revisions"}],"predecessor-version":[{"id":13558,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13360\/revisions\/13558"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13360"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13360"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}