{"id":13349,"date":"2024-08-23T01:03:03","date_gmt":"2024-08-22T23:03:03","guid":{"rendered":"https:\/\/valintermed.com\/?p=13349"},"modified":"2024-08-23T01:03:03","modified_gmt":"2024-08-22T23:03:03","slug":"makroglobulinemiya-valdenstrema","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/","title":{"rendered":"Waldenstrom&#039;s macroglobulinemia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Waldenstrom&#039;s macroglobulinemia (WMM) is a rare disease of the lymphatic system, which is a non-Hodgkin&#039;s lymphoma characterized by an increase in the level of IgM in the blood due to the proliferation of monoclonal B-lymphocytes. This disease is often accompanied by hyperviscosity of the blood, which in turn can lead to impaired microcirculation and other complications. WMM can manifest itself with various symptoms, such as malaise, anemia, thrombocytopenia, skin manifestations, etc. The pathology is chronic and requires careful monitoring and a modern approach to treatment, which is discussed below.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/macroglobulinemiya-valdenstrema\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Waldenstr\u00f6m&#039;s macroglobulinemia was first described by Swedish physician Jan G. Waldenstr\u00f6m in 1944. He noted that patients with the disease had unusually high levels of macroglobulins in the blood serum, which was associated with various clinical manifestations. Later studies confirmed that CF is a special variant of lymphoproliferative disease. Over time, various theories about the pathogenesis of the disease have emerged, enriching scientific knowledge and practice in oncology and hematology. Until now, CF attracts the attention of doctors and scientists, emphasizing the importance of further studying the mechanism of action of clinical manifestations and the effectiveness of the treatment methods used.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Waldenstr\u00f6m&#039;s macroglobulinemia is quite rare, with an incidence of approximately 3-4 cases per 1 million population per year. The disease is most often diagnosed in patients over 60 years of age, with a strong predisposition to the disease among men. According to several epidemiological studies, the incidence rate may vary depending on the region and ethnicity. For example, higher levels of MV have been reported in the American Indian population. In addition, according to a 2021 study, the survival rate of patients with this disease has significantly improved due to new treatments, although the long-term prognosis is still unclear.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Genetic changes play an important role in the pathogenesis of Waldenstr\u00f6m&#039;s macroglobulinemia. In most cases, WAMG is caused by mutations in genes involved in cell cycle and apoptosis regulation. One of the most well-known genetic changes is the MYD88 mutation (usually L265P), which is observed in approximately 90% patients with CF. This change leads to the activation of various signaling pathways that promote the survival and proliferation of malignant cells. Other mutations, such as in the CXCR4 genes, can also be identified, but their frequency is much lower. Further research in this area may lead to a better understanding of the disease mechanism and its treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are a number of factors that may increase your chance of developing Waldenstrom&#039;s macroglobulinemia. These include:<\/p>\n<ul>\n<li>Age: The incidence increases in patients over 60 years of age.<\/li>\n<li>Gender: Men are more likely to suffer from this disease than women.<\/li>\n<li>Ethnicity: Increased incidence has been noted among some ethnic groups.<\/li>\n<li>Chemical factors: Exposure to certain chemicals, such as benzene, may be associated with an increased risk.<\/li>\n<li>Immunodeficiency states: the presence of diseases that suppress the immune response increases the likelihood of developing lymphoproliferative diseases.<\/li>\n<\/ul>\n<p>The combination of these factors highlights the need for careful monitoring of patients identified as at risk.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of Waldenstrom&#039;s macroglobulinemia involves several key components. The main symptoms that may help in suspecting this disorder include:<\/p>\n<ul>\n<li>Fatigue and malaise.<\/li>\n<li>Hyperviscosity (headaches, blurred vision, tinnitus).<\/li>\n<li>Weight loss and night sweats.<\/li>\n<li>Bleeding and bruising.<\/li>\n<\/ul>\n<p>Laboratory tests, including serum IgM levels and monoclonal protein testing, are used to confirm the diagnosis. Radiologic tests, such as CT and MRI, may be used to evaluate lymph node or organ enlargement. Other tests, such as bone marrow biopsy, help determine the extent of involvement and cell characteristics. Differential diagnosis is important to rule out other conditions, such as multiple myeloma or chronic lymphocytic leukemia.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of Waldenstrom&#039;s macroglobulinemia may vary depending on the severity of the disease, clinical manifestations, and the patient&#039;s general condition. For asymptomatic diseases, observation may be recommended. If the disease requires active intervention, the following are used:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>General treatment: mainly aimed at restoring normal blood viscosity and improving the patient&#039;s condition.<\/li>\n<li>Pharmacological treatment: drugs such as chemotherapeutic agents (eg, fludarabine, bortezomib combinations) and monoclonal antibodies (eg, rituximab) are used.<\/li>\n<li>Surgical treatment: may be indicated in rare cases when there is a need to remove tumor formations.<\/li>\n<li>Other treatments: use of plasmapheresis to correct hyperviscosity and prevent complications.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Rituximab<\/li>\n<li>Fludarabine<\/li>\n<li>Bortezomib<\/li>\n<li>Decarbazine<\/li>\n<li>Cyclophosphamide<\/li>\n<li>Plasmapheresis<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of Waldenstr\u00f6m&#039;s macroglobulinemia involves regular follow-up examinations and evaluation of laboratory parameters, such as IgM levels and complete blood counts. It is also important to monitor for possible complications, such as thrombosis or infections. The prognosis depends on the early diagnosis and the therapy used, but regular monitoring of complications and the patient&#039;s condition can significantly improve quality of life and prolong its duration.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Waldenstrom&#039;s macroglobulinemia usually manifests itself in people over 60 years of age, but cases of the disease at a younger age are possible. Elderly patients are more likely to have concomitant diseases, which can complicate diagnosis and treatment. In younger patients, the disease usually proceeds more aggressively and requires a more active approach to treatment. It is important to approach each case individually and take into account age-related characteristics when choosing a treatment regimen.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is Waldenstrom&#039;s macroglobulinemia?<\/strong> It is a non-Hodgkin&#039;s lymphoma characterized by excessive production of IgM, leading to hyperviscosity and various clinical manifestations.<\/li>\n<li><strong>What are the main symptoms of the disease?<\/strong> Symptoms include fatigue, headaches, visual disturbances, and the discovery of enlarged lymph nodes.<\/li>\n<li><strong>How is CF diagnosed?<\/strong> Diagnosis includes IgM levels, laboratory tests, radiological examinations and biopsy to study the cellular structure.<\/li>\n<li><strong>How is Waldenstrom&#039;s macroglobulinemia treated?<\/strong> Treatment may include observation, chemotherapy, monoclonal antibodies, and plasmapheresis.<\/li>\n<li><strong>What is the prognosis for patients with this disease?<\/strong> The prognosis depends on the timeliness of diagnosis and the therapy used; thanks to new treatment methods, survival rates have improved significantly.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Waldenstrom&#039;s macroglobulinemia (WM) is a rare disease of the lymphatic system that is a non-Hodgkin&#039;s lymphoma characterized by an increase in the level of IgM in the blood due to<\/p>","protected":false},"author":1,"featured_media":23984,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13349","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13349","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13349"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13349\/revisions"}],"predecessor-version":[{"id":13569,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13349\/revisions\/13569"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/23984"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13349"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13349"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13349"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}