{"id":13147,"date":"2024-08-23T04:26:24","date_gmt":"2024-08-23T02:26:24","guid":{"rendered":"https:\/\/valintermed.com\/?p=13147"},"modified":"2024-08-23T04:26:24","modified_gmt":"2024-08-23T02:26:24","slug":"disgeneziya-schitovidnoy-zhelezy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/","title":{"rendered":"Thyroid dysgenesis"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Thyroid dysgenesis is a group of disorders characterized by abnormal development or structural abnormalities of the thyroid gland. This disease can manifest as partial or complete underdevelopment of the gland, which leads to various endocrine disorders associated with insufficient production of thyroid hormones. It is important to note that thyroid dysgenesis can have both genetic and environmental origins. Some forms of dysgenesis can be associated with other syndromes, such as Dunning syndrome or Klinefelter syndrome, which adds complexity to the diagnostic process and clinical management.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of drugs used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/dysgenesis-of-the-schitovidnoy-gland\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of thyroid dysgenesis can be traced back to the beginning of the study of endocrine diseases. In the 19th century, physicians began to notice a correlation between abnormalities in the development of the thyroid gland and clinical symptoms of hypothyroidism. In 1893, German pathologist William Steiner described cases of thyroid absence in patients, which later served as the basis for further research into the problem. In the 1970s, with the rise of genetics and molecular biology, genetic markers associated with thyroid dysgenesis began to be studied, which allowed us to clarify the etiology of this disorder.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to statistics, thyroid dysgenesis occurs with a frequency of 1:4000 to 1:7000 newborns, which makes it one of the most common hereditary endocrine diseases. According to research data, the incidence among women is significantly more frequent than among men, which emphasizes the importance of genetic and hormonal correction in diagnosis and treatment. Epidemiological studies also show that about 90% cases of dysgenesis can be attributed to forms directly associated with mutations in certain genes, such as TSHR, PAX8 and FOXE1.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research shows that thyroid dysgenesis has a genetic predisposition and may be associated with various mutations in neurotrophic genes. The genes involved include:<\/p>\n<ul>\n<li>TSHR (thyroid stimulating hormone receptor gene)<\/li>\n<li>PAX8 (a gene responsible for the development of the thyroid gland)<\/li>\n<li>FOXE1 (a gene responsible for the formation of lymphoid cells in the thyroid gland)<\/li>\n<li>NKX2-1 (a gene that affects lung and thyroid development)<\/li>\n<\/ul>\n<p>These genes play a key role in the normal development and functioning of the thyroid gland, and their mutations can lead to either the complete absence of the organ or its underdevelopment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors that contribute to the development of thyroid dysgenesis are varied and may include:<\/p>\n<ul>\n<li>Heredity: presence of cases of the disease in the family history.<\/li>\n<li>Physical factors (effects of radiation during pregnancy)<\/li>\n<li>Chemical factors (exposure to certain toxins such as polychlorinated biphenyls)<\/li>\n<li>Autoimmune disorders (maternal history of autoimmune diseases such as Hashimoto&#039;s thyroiditis)<\/li>\n<li>Lack of iodine in the diet (both mother and child)<\/li>\n<\/ul>\n<p>Knowledge of these risk factors allows for the optimization of monitoring of pregnant women and newborns for early detection and treatment of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of thyroid dysgenesis is made on the basis of several examination methods:<\/p>\n<ul>\n<li>Main symptoms: Children may experience delayed physical and mental development, as well as specific skin changes and chronic infections.<\/li>\n<li>Laboratory tests: tests for thyroid hormone levels (TSH, free T4) help to identify hypothyroidism, which is characteristic of this pathology.<\/li>\n<li>Radiological examinations: Ultrasound of the thyroid gland allows you to assess its size and structure, as well as the presence of abnormalities.<\/li>\n<li>Other types of diagnostics: scintigraphy allows you to study the functional state of the thyroid tissue.<\/li>\n<li>Differential diagnosis: Other causes of hypothyroidism and thyroid disease, such as thyroiditis and tumors, should be excluded.<\/li>\n<\/ul>\n<p>Identification of pathology at early stages is vital for the appointment of adequate treatment and prevention of complications.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of thyroid dysgenesis involves several approaches:<\/p>\n<ul>\n<li>General treatment: monitoring and maintenance of thyroid hormone levels in patients with hypothyroidism.<\/li>\n<li>Pharmacological treatment: replacement therapy with levothyroxine, which helps maintain normal hormone levels in the blood.<\/li>\n<li>Surgery: In rare cases, thyroid surgery may be required if there are large nodules or abnormalities.<\/li>\n<li>Other treatments include using a diet rich in iodine and vitamins, and correcting any associated conditions.<\/li>\n<\/ul>\n<p>Specific treatment protocols must be followed depending on the patient&#039;s age and the severity of symptoms.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of drugs used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat thyroid dysgenesis include:<\/p>\n<ul>\n<li>Levothyroxine (Euthyrox, L-thyroxine)<\/li>\n<li>Triiodothyronine (if additional therapy is required)<\/li>\n<li>Vitamin D (to support overall health)<\/li>\n<li>Potassium iodide (for iodine deficiency in food)<\/li>\n<\/ul>\n<p>Regular monitoring of the thyroid gland allows for adjustment of dosages and prescription of drugs depending on the clinical situation.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of thyroid function includes:<\/p>\n<ul>\n<li>Control stages: regular tests for TSH and T4 levels to assess the effectiveness of replacement therapy.<\/li>\n<li>Prognosis: With adequate therapeutic support, most patients lead a normal life.<\/li>\n<li>Complications: Long-term hypothyroidism can lead to poor physical and mental development, so early diagnosis is critical.<\/li>\n<\/ul>\n<p>Constant monitoring by specialists allows for timely changes to be made to therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Thyroid dysgenesis has its own characteristics in different age groups:<\/p>\n<ul>\n<li>In newborns: presents with severe symptoms of hypothyroidism such as constipation, jaundice, and lack of response to external stimuli.<\/li>\n<li>In children: may affect growth and development, causing mental retardation.<\/li>\n<li>In adults: Often associated with other autoimmune diseases, such as Graves&#039; disease.<\/li>\n<\/ul>\n<p>Such differences in manifestations emphasize the need for an individual approach to each age stage.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is thyroid dysgenesis?<\/strong> This is a condition characterized by underdevelopment or abnormalities in the structure of the thyroid gland, resulting in insufficient production of thyroid hormones.<\/li>\n<li><strong>What are the symptoms of thyroid dysgenesis?<\/strong> The main symptoms include delayed physical and mental development, general weakness, increased fatigue and changes in skin condition.<\/li>\n<li><strong>How is thyroid dysgenesis treated?<\/strong> Treatment usually involves replacement therapy with levothyroxine and may include surgery in rare cases.<\/li>\n<li><strong>What are the risk factors for thyroid dysgenesis?<\/strong> Risk factors include hereditary predisposition, physical and chemical exposure, and iodine deficiency.<\/li>\n<li><strong>What is the role of genetic factors in the development of thyroid dysgenesis?<\/strong> There are several genes, such as TSHR and PAX8, that when mutated can lead to this pathology, indicating a strong genetic predisposition.<\/li>\n<\/ul>\n<p>This article aims to help in understanding the nature of thyroid dysgenesis, its diagnosis, treatment and features, confirming the importance of early detection and adequate medical care.<\/p>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Thyroid dysgenesis is a group of disorders characterized by abnormal development or structural abnormalities of the thyroid gland. This disorder can manifest as<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13147","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13147"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13147\/revisions"}],"predecessor-version":[{"id":13773,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13147\/revisions\/13773"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13147"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13147"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}