{"id":13136,"date":"2024-08-23T04:36:54","date_gmt":"2024-08-23T02:36:54","guid":{"rendered":"https:\/\/valintermed.com\/?p=13136"},"modified":"2024-08-23T04:36:54","modified_gmt":"2024-08-23T02:36:54","slug":"bolezn-tanzhera","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/tanner-disease\/","title":{"rendered":"Tangier disease"},"content":{"rendered":"
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Tangier disease is a rare hereditary disorder characterized by very low levels of high-density lipoproteins (HDL) and cholesterol metabolism disorders. The main cause of the disease is a mutation in the ABCA1 gene, which is involved in the transport of cholesterol and phospholipids from cells to HDL. This leads to the accumulation of cholesterol in tissues, especially in lymphoid tissue, liver and spleen, which in turn can cause various clinical manifestations, such as lymph node hypertrophy, jaundice and anemia. Tangier disease is also associated with an increased risk of atherosclerosis and cardiovascular disease, despite low total cholesterol levels.<\/p>\n

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