{"id":13107,"date":"2024-08-23T05:07:46","date_gmt":"2024-08-23T03:07:46","guid":{"rendered":"https:\/\/valintermed.com\/?p=13107"},"modified":"2024-08-23T05:07:46","modified_gmt":"2024-08-23T03:07:46","slug":"tihiy-tireoidit","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/","title":{"rendered":"Silent thyroiditis"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Silent thyroiditis, also known as subacute thyroiditis or de Quervain&#039;s thyroiditis, is an inflammatory disease of the thyroid gland that is characterized by an acute or subacute onset, accompanied by pain and enlargement of the gland. Most often, this disease occurs after a viral infection and is observed mainly in young women. During the development of silent thyroiditis, symptoms of thyrotoxicosis predominate, such as an increase in the level of thyroid hormones in the blood, which may be followed by hypothyroidism. Diagnosis of the disease is based on clinical manifestations, laboratory tests and instrumental methods. Treatment can be conservative, including corticosteroids and non-selective anti-inflammatory drugs, or surgical in case of complications.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/quiet-tire\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The term &quot;silent thyroiditis&quot; was introduced into medical practice in the mid-20th century, when doctors began to distinguish it from other forms of thyroiditis. The first descriptions of the disease refer to the works of famous pathologists who observed inflammatory changes in the thyroid tissue, which made it possible to distinguish the so-called subacute thyroiditis. Interestingly, in the 1930s, many doctors mistakenly attributed this disease to syphilis, as they observed similar symptoms. Today, it is known that most cases of silent thyroiditis are associated with viral infections, such as influenza and mumps. Scientific research over the years has confirmed the viral etiology of the disease, and also distinguished it from other thyroiditis, such as autoimmune and chronic Hashimoto&#039;s thyroiditis. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The epidemiology of silent thyroiditis shows that the disease is quite rare, but its incidence may vary. According to various epidemiological studies, the prevalence is from 4 to 15 cases per 100,000 people per year. The disease is diagnosed much more often in women, exceeding the frequency of diagnosis in men by 3-5 times. The peak incidence is observed at the age of 20 to 50 years, which is also confirmed by many clinical studies. Despite the apparent rarity, an important aspect is that silent thyroiditis may be underdiagnosed due to the similarity of symptoms with other thyroid diseases, such as thyrotoxicosis and autoimmune thyroiditis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The genetic predisposition to silent thyroiditis is not fully understood, but it is assumed that some mutations in certain genes may influence the development of the disease. Studies show that polymorphisms in genes associated with the immune response, such as HLA-DR and CTLA-4, are often found among patients with thyroiditis. Epigenetic factors may also influence the incidence of the disease. Moreover, a family history of thyroid disease, especially autoimmune thyroid disease, increases the risk of silent thyroiditis in other family members.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are several risk factors that contribute to the development of silent thyroiditis, which can be divided into physical and chemical. The main factors include:<\/p>\n<ul>\n<li>Viral infections: hypothermia or epidemics of viral diseases such as influenza or mumps.<\/li>\n<li>Connective tissue diseases: presence of diseases such as systemic lupus erythematosus or rheumatoid arthritis.<\/li>\n<li>Hormonal fluctuations: Pregnancy and the postpartum period can contribute to the development of the disease.<\/li>\n<li>Chemical exposure: Exposure of the body to chemicals such as pesticides.<\/li>\n<\/ul>\n<p>These factors are important indicators of the possibility of developing silent thyroiditis and require special attention in the process of diagnosis and prevention.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of silent thyroiditis is based on clinical examination and various laboratory and instrumental methods. The main symptoms include:<\/p>\n<ul>\n<li>Pain in the thyroid gland.<\/li>\n<li>Enlargement of the thyroid gland.<\/li>\n<li>Systemic symptoms such as fever, fatigue and muscle pain.<\/li>\n<\/ul>\n<p>Laboratory tests show an increase in thyroid hormone levels and a decrease in TSH levels at the initial stage, which may be followed by normalization or the development of hypothyroidism. Radiological tests, such as thyroid ultrasound, help assess the presence of inflammatory changes and the size of the gland. It is important to conduct a differential diagnosis with other forms of thyroiditis and pathologies, such as thyroid cancer.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of silent thyroiditis begins with conservative methods, including the use of nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation. In severe cases, corticosteroids may be required. Pharmacological treatment is aimed at correcting hormonal imbalances, which may include thyroid medications depending on the patient&#039;s condition. Surgery is generally rare and may be necessary in the case of abscess formation or compression of surrounding tissue. Other treatments may include physical therapy and a diet rich in vitamins and minerals.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used in the treatment of silent thyroiditis include:<\/p>\n<ul>\n<li>Ibuprofen - to relieve pain and inflammation.<\/li>\n<li>Naproxen is a longer-acting analogue of ibuprofen.<\/li>\n<li>Prednisolone - to reduce inflammation in severe forms.<\/li>\n<li>Levothyroxine - to correct hypothyroidism.<\/li>\n<li>Methylprednisolone - used in emergency situations.<\/li>\n<\/ul>\n<p>Each of these agents requires careful monitoring and prescription by a physician depending on the patient&#039;s condition.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring the course of silent thyroiditis includes regular check-ups of thyroid hormones and TSH levels, symptom control, and the patient&#039;s general condition to avoid potential complications such as the development of chronic hypothyroidism or relapse of the disease. The prognosis is usually favorable, but in some cases complications may arise that require more intensive treatment. It is important to remember that in patients with an acute course of the disease, recovery of thyroid function may take several months.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Age-related features of silent thyroiditis manifest themselves in different clinical pictures in children, young people and the elderly. In young people and women of reproductive age, the disease often occurs with pronounced symptoms of thyrotoxicosis. In elderly patients, it may have less pronounced manifestations and is often diagnosed late. Children may also show symptoms, but they are less susceptible to this disease. In the elderly, long-term and severe forms of the disease are often observed, which requires special attention.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of silent thyroiditis?<\/strong> The main symptoms are pain in the thyroid gland, an increase in its size, symptoms of thyrotoxicosis such as fatigue, weight loss and tremor.<\/li>\n<li><strong>How to diagnose silent thyroiditis?<\/strong> Diagnosis includes clinical examination, laboratory tests for thyroid hormone levels and TSH, thyroid ultrasound and differential diagnosis with other diseases.<\/li>\n<li><strong>What is the treatment for silent thyroiditis?<\/strong> Treatment includes NSAIDs to reduce pain, corticosteroids for severe cases, and hormone therapy if hypothyroidism develops.<\/li>\n<li><strong>What is the prognosis for silent thyroiditis?<\/strong> The prognosis is generally good, but regular monitoring is necessary to avoid the development of chronic hypothyroidism.<\/li>\n<li><strong>What are the risk factors for developing silent thyroiditis?<\/strong> Risk factors include the presence of viral infections, connective tissue diseases and hormonal changes, such as during pregnancy.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Silent thyroiditis, also known as subacute thyroiditis or de Quervain&#039;s thyroiditis, is an inflammatory disease of the thyroid gland that is characterized by acute<\/p>","protected":false},"author":1,"featured_media":23435,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13107","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13107","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13107"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13107\/revisions"}],"predecessor-version":[{"id":13813,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13107\/revisions\/13813"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/23435"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13107"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13107"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13107"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}