{"id":13103,"date":"2024-08-23T05:11:11","date_gmt":"2024-08-23T03:11:11","guid":{"rendered":"https:\/\/valintermed.com\/?p=13103"},"modified":"2024-08-23T05:11:11","modified_gmt":"2024-08-23T03:11:11","slug":"subependimalnaya-uzelkovaya-geterotopiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/","title":{"rendered":"Subependymal nodular heterotopia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Subependymal nodular heterotopia (SNH) is a neurodevelopmental disorder characterized by abnormal arrangement of neurons within brain cells, particularly in the subependymal zone. The disorder is characterized by heterotopic nodules of neuronal cells that form outside the normal structure of the cerebral cortex. SNH is most often diagnosed in childhood and adolescence and is associated with epilepsy and various neurological disorders. The pathogenesis of the disease involves disruption of neurogenesis and migration of neuronal precursors during prenatal development, resulting in the formation of abnormal neuronal clusters. <\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/subependimal-uzelkovaya-geterotopiya\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of studying subependymal nodular heterotopia dates back to the late 19th century, when scientists first began to describe the morphological changes observed in patients with epileptic seizures. In the 1930s, A. M. Benedict and his colleagues coined the term &quot;heterotopia&quot; and began to systematize the observed forms. Interestingly, in the 1970s, significant progress was made in neuroimaging, which allowed for more accurate diagnosis of SNH. The study of the influence of microecological factors and genetic predisposition on the development of heterotopia has become popular among neurologists. Many authors focus on the relationship of this disease with other neurological disorders, as well as on changes in neuroglia and neuronal interactivity.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Subependymal nodular heterotopia is a relatively rare disease, occurring in 1 in 2,000\u20134,000 children, which emphasizes its low prevalence in the general population. There are statistics showing that in patients suffering from epilepsy, the frequency of heterotopia detection is significantly higher and reaches 20-30%. Interestingly, heterotopia is observed more often in girls than in boys, which makes the study of sex differences in the pathogenesis and pathophysiology of the disease relevant. It should also be taken into account that many patients may have associated concomitant neurological symptoms, which makes it difficult to assess the true prevalence of the disease in clinical practice.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Analysis of genetic factors associated with subependymal nodular heterotopia has identified several key genes that may be involved in the pathogenesis. For example, mutations in the DCX and LIS1 genes have been identified, which play an important role in neuronal migration and cell polarity. Hereditary transmission of this disease is observed in some patients, which indicates the possibility of a genetic predisposition. The study of genomic and molecular markers also allows us to delve into the mechanisms of cellular disorders within the heterotopia. The main directions of current research are focused on identifying new mutations and their role in the formation of heterotopic nodules.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Among the risk factors that contribute to the development of subependymal nodular heterotopia are the following: <\/p>\n<ul>\n<li>Genetic predisposition (mutations in specific genes);<\/li>\n<li>Prenatal factors (infections during pregnancy, toxicosis, lack of oxygen);<\/li>\n<li>Environmental impacts (exposure to chemical compounds such as toxins and heavy metals);<\/li>\n<li>Disturbances in the process of neuronal migration during embryonic development;<\/li>\n<li>Age of mother at pregnancy.<\/li>\n<\/ul>\n<p>These factors can influence both prenatal and postnatal development. The role of environmental factors is of interest, as studies show that living conditions can influence the health of the final organism and activate latent genetic mutations.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main symptoms of subependymal nodular heterotopia include severe epileptic seizures, various motor dysfunctions, and cognitive disorders. A range of laboratory and radiological methods are used to diagnose the disease. These include:<\/p>\n<ul>\n<li>Electroencephalography (EEG) to detect epileptic activity;<\/li>\n<li>Magnetic resonance imaging (MRI) to visualize anatomical changes;<\/li>\n<li>Clinical examinations to assess neurological status;<\/li>\n<li>Genetic tests to detect specific mutations;<\/li>\n<li>Clinical observations based on the patient&#039;s medical history.<\/li>\n<\/ul>\n<p>The differential diagnosis includes conditions such as craniopharyngioma, astrocytomas and other neurological disorders, which requires a careful approach and a multidisciplinary approach in the diagnosis and treatment of patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of subependymal nodular heterotopia is a multi-step process that includes both medical and surgical methods. Pharmacological treatment is aimed primarily at controlling epileptic seizures using antiepileptic drugs such as:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Lamotrigine;<\/li>\n<li>Carbamazepine;<\/li>\n<li>Valproic acid.<\/li>\n<\/ul>\n<p>In cases where conservative treatment is ineffective and epilepsy is severe, surgical intervention may be considered, including resection of heterotopic nodules or cortical resection. Thus, the treatment approach should be personalized, taking into account the clinical characteristics of the patient and the course of the disease. Alternative treatments, such as neurostimulation, are also discussed, but their effectiveness requires further research.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used in the treatment of subependymal nodular heterotopia are:<\/p>\n<ul>\n<li>Lamotrigine;<\/li>\n<li>Valproic acid;<\/li>\n<li>Carbamazepine;<\/li>\n<li>Retigabine;<\/li>\n<li>Topiramate;<\/li>\n<li>Clonazepam.<\/li>\n<\/ul>\n<p>The selection of therapy is carried out taking into account the individual characteristics of each patient, his medical history and the symptoms presented.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with subependymal nodular heterotopia includes regular examinations and symptom monitoring. The main stages of monitoring are:<\/p>\n<ul>\n<li>Periodic neurological examinations;<\/li>\n<li>Regular EEG studies to assess activity;<\/li>\n<li>MRI to track changes in the brain;<\/li>\n<li>Evaluation of the effectiveness of the treatment;<\/li>\n<li>Discussing the prognosis and future plans with the patient and family.<\/li>\n<\/ul>\n<p>The prognosis depends on the severity of neurological impairment and the time of treatment. Possible complications include recurrence of epileptic problems, deterioration of cognitive function, and the need for repeat surgery.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Subependymal nodular heterotopia has variable age-related manifestations. Neonates and young children have more pronounced neurological symptoms, which may manifest as developmental delays and epileptic seizures. In adolescence, the disease may lead to multiple seizures, significantly impairing quality of life. Adult patients often become more resistant to treatment, but may continue to experience neurological dysfunction that requires ongoing monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is subependymal nodular heterotopia?<\/strong> It is a neurodevelopmental disorder characterized by abnormal arrangement of neurons in the subependymal zone of the brain, leading to various neurological disorders, including epilepsy.<\/li>\n<li><strong>What are the main symptoms of this disease?<\/strong> The main symptoms include seizures, motor disorders, developmental delays and cognitive impairment.<\/li>\n<li><strong>What are the diagnostic methods for subependymal nodular heterotopia?<\/strong> Diagnostic methods include electroencephalography, magnetic resonance imaging, laboratory tests, and genetic testing.<\/li>\n<li><strong>What treatment is most effective for patients with this disease?<\/strong> Treatment includes drug therapy using antiepileptic drugs, and if ineffective, surgical intervention.<\/li>\n<li><strong>What is the risk of complications with subependymal nodular heterotopia?<\/strong> The risk of complications varies, but may include recurrence of epilepsy, deterioration in cognitive function, and the need for repeat surgery.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Subependymal nodular heterotopia (SNH) is a neurodevelopmental disorder characterized by abnormal arrangement of neurons within brain cells, particularly in<\/p>","protected":false},"author":1,"featured_media":23427,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13103","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13103","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13103"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13103\/revisions"}],"predecessor-version":[{"id":13817,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13103\/revisions\/13817"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/23427"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13103"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13103"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13103"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}