{"id":13066,"date":"2024-08-23T05:46:42","date_gmt":"2024-08-23T03:46:42","guid":{"rendered":"https:\/\/valintermed.com\/?p=13066"},"modified":"2024-08-23T05:46:42","modified_gmt":"2024-08-23T03:46:42","slug":"spinotserebellyarnaya-ataksiya-tip-27","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/spinal-cord-injury-tip-27\/","title":{"rendered":"Spinocerebellar ataxia type 27"},"content":{"rendered":"
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Spinocerebellar ataxia type 27 (SCA27) is a neurodegenerative disorder belonging to the group of spinocerebellar ataxias, characterized by progressive impairment of motor coordination and balance, as well as the development of atrophy of the cerebellum and other structures of the central nervous system. This disease has an autosomal dominant inheritance and is caused by mutations in the TBP (TATA-binding protein) gene, which leads to a disruption in the normal functioning of the protein involved in the regulation of gene transcription. Clinical manifestations can vary, including impairment of fine motor skills, speech production and other coordination functions, the appearance of rhetorical and vestibular disorders. The onset of the disease is often observed in young or middle age, which emphasizes the importance of early diagnosis and an effective treatment approach.<\/p>\n

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