{"id":13058,"date":"2024-08-23T05:55:58","date_gmt":"2024-08-23T03:55:58","guid":{"rendered":"https:\/\/valintermed.com\/?p=13058"},"modified":"2024-08-23T05:55:58","modified_gmt":"2024-08-23T03:55:58","slug":"spinotserebellyarnaya-ataksiya-tip-12","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/spinal-cord-injury-tip-12\/","title":{"rendered":"Spinocerebellar ataxia type 12"},"content":{"rendered":"
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Spinocerebellar ataxia type 12 (SCA12) is a genetic disorder belonging to the group of spinocerebellar ataxias, characterized by progressive impairment of motor coordination, balance, and various neurological symptoms. This hereditary disorder is inherited in a dominant manner and is caused by a mutation in the ATXN3 gene, which leads to the accumulation of aberrant forms of the protein and, ultimately, neurodegeneration in certain areas of the central nervous system. The main clinical manifestations of SCA12 include ataxia, dyspraxia, nystagmus, balance disorders, and changes in productive behavior. The onset of the disease usually occurs in middle age, but can vary depending on the specific mutations.<\/p>\n

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