{"id":13055,"date":"2024-08-23T06:00:45","date_gmt":"2024-08-23T04:00:45","guid":{"rendered":"https:\/\/valintermed.com\/?p=13055"},"modified":"2024-08-23T06:00:45","modified_gmt":"2024-08-23T04:00:45","slug":"spinotserebellyarnaya-ataksiya-tip-1","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/spinal-cord-injury-tip-1\/","title":{"rendered":"Spinocerebellar ataxia type 1"},"content":{"rendered":"
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Spinocerebellar ataxia type 1 (SCA1) is a genetically determined neurodegenerative disease belonging to the group of spinocerebellar ataxias, which is characterized by progressive disorders of motor coordination and balance. The disease is based on the degeneration of neurons in the cerebellum and other parts of the central nervous system. SCA1 is caused by a pathogenic expansion of a single nucleotide repeat of CAG in the ATXN1 gene, which leads to the formation of toxic proteins. Symptoms of the disease usually begin between the ages of 30 and 50 years and include ataxic movements, dysmetria, and speech disorders. Progression of the disease leads to a loss of independence in everyday life and significantly worsens the quality of life of patients, causing the need for long-term rehabilitation and supportive care.<\/p>\n

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