{"id":13041,"date":"2024-08-23T06:15:00","date_gmt":"2024-08-23T04:15:00","guid":{"rendered":"https:\/\/valintermed.com\/?p=13041"},"modified":"2024-08-23T06:15:00","modified_gmt":"2024-08-23T04:15:00","slug":"spasticheskaya-paraplegiya-tip-3a","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/spastic-paraplegia-type-3a\/","title":{"rendered":"Spastic paraplegia type 3A"},"content":{"rendered":"
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Spastic paraplegia type 3A (SPG3A) is a hereditary neurodegenerative disease characterized by progressive weakness and spasticity of the lower limbs. This disorder is characterized by impaired motor functions caused by degradation of axons in the cerebral cortex and spinal centers. Exacerbation of spasticity and insufficient coordination of movements can significantly worsen the patient's quality of life. The etiology of this disease is based on a mutation in the SPAST gene, located on chromosome 2. Genetic changes lead to suppression of the synthesis of the protein responsible for microtubules in cells, which leads to disruption of their normal functioning. Clinical manifestations usually occur in childhood or adolescence, but can also manifest in later life.<\/p>\n

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