{"id":13031,"date":"2024-08-23T06:25:00","date_gmt":"2024-08-23T04:25:00","guid":{"rendered":"https:\/\/valintermed.com\/?p=13031"},"modified":"2024-08-23T06:25:00","modified_gmt":"2024-08-23T04:25:00","slug":"solitarnaya-fibroznaya-opuhol","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/","title":{"rendered":"Solitary fibrous tumor"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that can occur in various tissues of the body, most commonly in the lungs, pleura, soft tissues, and bones. This disease is characterized by the formation of a benign tumor consisting of fibroblasts, hyalinized intercellular matrix, and inflammatory elements. SFT can be associated with various symptoms, including respiratory failure, chest pain, and cough, but in some cases it is asymptomatic. This tumor has a high rate of local recurrence after surgical removal, which necessitates careful diagnosis and monitoring after treatment.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/solitary-fibrous-tumor\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Solitary fibrous tumor was first described in the medical literature in 1931, when G. M. Boyer drew attention to the peculiarities of the morphological structure of the tumor found in patients with pleurisy. In the following decades, a number of researchers continued to study this pathology, determining its characteristic signs and clinical features. An interesting fact is that at first, SFT was considered an exclusively pleural tumor, but later it was established that this disease can be localized in various organs, including joints, lungs and soft tissues. This expansion of the understanding of the disease led to the emergence of many scientific publications describing clinical cases, diagnostic methods and approaches to treatment, including both surgical intervention and conservative methods.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Solitary fibrous tumor is extremely rare, and according to various sources, its incidence is from 0.5 to 6 cases per 1 million people per year. It is noted that the disease occurs slightly more often in men than in women. Most often, the diagnosis is made at the age of 20 to 60 years, but there are cases of SFT detection in both children and the elderly. According to research, 60-80% of all SFT cases are localized in the lungs, and only about 20-40% are observed in other organs, such as soft tissues or bones.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Currently, active research is underway to identify genetic predisposition to solitary fibrous tumor. The necessary data indicate the possible involvement of genes associated with cell proliferation and differentiation, but the exact mechanisms remain unclear. In some cases, mutations in the expression of genes encoding proto-oncogenes and tumor suppressors are detected, which requires further study to determine the specific role of genetic factors in the development of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Identifying risk factors that contribute to the development of solitary fibrous tumor is a complex task. Several potential triggers have been identified that may influence the likelihood of this tumor-like formation:<\/p>\n<ul>\n<li>Occupational diseases and asbestos exposure.<\/li>\n<li>Radioactive radiation and its effects on tissues.<\/li>\n<li>External chemicals such as carcinogens.<\/li>\n<li>Chronic inflammatory processes in the lungs or other organs.<\/li>\n<li>The patient&#039;s age and gender may also influence the level of risk.<\/li>\n<\/ul>\n<p>Despite the above factors, clear cause-and-effect relationships still require further research.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of solitary fibrous tumor includes several key stages. The main symptoms of the disease may include:<\/p>\n<ul>\n<li>Cough, which can be either dry or wet.<\/li>\n<li>Chest pain.<\/li>\n<li>Shortness of breath and noisy breathing.<\/li>\n<li>General symptoms such as fatigue and weight loss.<\/li>\n<\/ul>\n<p>Laboratory tests usually include a complete blood count and pulmonary function tests to evaluate the respiratory system. Radiological examinations such as chest radiography, computed tomography, and magnetic resonance imaging are the main tools for visualizing the tumor and assessing its size and location. Imaging methods can reveal characteristic features of the SFO, such as clear margins and the presence of necrotic changes. In addition, a biopsy can be used to finally verify the diagnosis and determine the histological type of the tumor. Differential diagnosis should be performed with other pulmonary lesions, including metastases and benign tumors, to determine the most likely diagnosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of solitary fibrous tumor is based on its morphological type, size, and general condition of the patient. The main method remains surgical intervention. Surgical removal of the tumor can be performed both by open and minimally invasive methods. In cases of diseases accompanied by pronounced symptoms, radical surgical excision is preferable. Pharmacological treatment can be used as an additional therapy, but specific drugs for the treatment of SFT have not been developed. Conservative methods, such as observation, can also be recommended in asymptomatic cases. In some cases, especially in case of relapses, radiation therapy can be considered.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are currently no specific drugs aimed at treating solitary fibrous tumors. However, the following classes of drugs are used in clinical practice:<\/p>\n<ul>\n<li>Nonsteroidal anti-inflammatory drugs (eg, ibuprofen) for symptomatic treatment of pain.<\/li>\n<li>Medicines for the relief of inflammatory processes in the presence of complications.<\/li>\n<li>Opioid analgesics for severe pain syndrome.<\/li>\n<\/ul>\n<p>Due to the lack of approved treatment guidelines, the individual characteristics of the patient and the treatment being administered must be taken into account.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring patients with solitary fibrous tumor is an important aspect of clinical management. Monitoring steps include:<\/p>\n<ul>\n<li>Regular radiological examinations to monitor for possible recurrence.<\/li>\n<li>Clinical examinations to monitor health status and symptoms.<\/li>\n<li>Laboratory tests to assess the general condition and identify concomitant diseases.<\/li>\n<\/ul>\n<p>The prognosis for patients with SFO is usually favorable, provided the tumor is completely removed. However, in cases with recurrences or indeterminate forms, the prognosis may worsen. Complications may include the need for repeated operations and the development of pulmonary diseases.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Solitary fibrous tumor can manifest itself in different age groups, but the incidence varies significantly. In children, the disease usually has a somewhat less aggressive course and often proceeds without noticeable clinical symptoms. In older people, the presence of concomitant diseases can complicate diagnosis and treatment, which requires a careful approach to monitoring and selection of therapeutic measures. It is important to consider age factors when planning treatment and monitoring health.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is solitary fibrous tumor?<\/strong><br \/>\nSolitary fibrous tumor is a rare mesenchymal tumor, often seen in the lungs, characterized by a benign course and the potential for recurrence.\n<\/li>\n<li><strong>What are the main symptoms of solitary fibrous tumor?<\/strong><br \/>\nSymptoms may include cough, chest pain, shortness of breath, and general weakness. However, the disease may be asymptomatic.\n<\/li>\n<li><strong>How is solitary fibrous tumor diagnosed?<\/strong><br \/>\nDiagnosis is based on physical examination, radiography, CT scan, MRI and biopsy to confirm the diagnosis.\n<\/li>\n<li><strong>How is solitary fibrous tumor treated?<\/strong><br \/>\nThe main method of treatment is surgical removal of the tumor, but medications for symptomatic treatment may also be used.\n<\/li>\n<li><strong>What is the prognosis for solitary fibrous tumor?<\/strong><br \/>\nWith early diagnosis and radical removal of the tumor, the prognosis is usually favorable, but there is a risk of recurrence, which requires monitoring and observation.\n<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Solitary fibrous tumor (SFT) is a rare mesenchymal tumor that can occur in various tissues of the body, most commonly in the lungs,<\/p>","protected":false},"author":1,"featured_media":23209,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-13031","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=13031"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13031\/revisions"}],"predecessor-version":[{"id":13890,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/13031\/revisions\/13890"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/23209"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=13031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=13031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=13031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}