{"id":12994,"date":"2024-08-23T07:01:27","date_gmt":"2024-08-23T05:01:27","guid":{"rendered":"https:\/\/valintermed.com\/?p=12994"},"modified":"2024-08-23T07:01:27","modified_gmt":"2024-08-23T05:01:27","slug":"sindrom-korotkoy-kishki","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/","title":{"rendered":"Short bowel syndrome"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Short bowel syndrome (SBS) is a clinical condition caused by a lack of functional intestinal length, which leads to impaired absorption of nutrients and water. This condition may develop as a result of surgical removal of a significant portion of the intestine, as a result of congenital anomalies such as mesenteric adenitis or enterocellular diarrhea. Symptoms of the disease include diarrhea, malnutrition, weight loss, and various metabolic disorders, which requires a comprehensive approach to treatment. A proper understanding of short bowel syndrome is essential to reduce the risk of serious complications and improve the quality of life of patients.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/short-bowel-syndrome\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Short bowel syndrome was first described in clinical practice in the mid-20th century, but its publications date back even earlier, when doctors tried to explain the causes of severe digestive disorders in patients. One of the first researchers of this condition was a surgeon who, after an operation to remove part of the intestine, noticed characteristic changes in digestion in his patients. In the 1960s, attention to this syndrome increased due to the development of surgical methods for the treatment of bowel diseases. In the following years, active research began in the field of pathogenesis, diagnosis and treatment of SBS. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to current data, short bowel syndrome occurs with a frequency of 5-10 cases per 100,000 population per year. It can develop in patients of all age groups, but most often this syndrome is observed in children who have undergone bowel surgery. According to several studies, more than 80% cases of SBS in children are associated with irreversible intestinal damage caused by conditions such as necrotizing enterocolitis. According to some data, about 60% patients with short bowel require parenteral nutrition to maintain adequate nutrient levels in the body.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There is a possibility of a genetic predisposition to short bowel syndrome, especially in cases of congenital anomalies. In recent years, several genes have been identified that may play a role in the pathogenesis of this disease. For example, mutations in the LPH (lactose fermentation) gene affect the ability of the intestine to absorb various nutrients. Also, according to some studies, changes in genes responsible for the proliferation of intestinal epithelial cells may predispose to the development of this syndrome. This emphasizes the importance of genetic counseling for patients with a family history of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors that contribute to the development of short bowel syndrome can be divided into several categories:<\/p>\n<ul>\n<li>Physical factors:\n<ul>\n<li>Surgeries on the intestines, including resections for diseases such as cancer or ulcers.<\/li>\n<li>Intestinal injuries due to road accidents or other injuries.<\/li>\n<li>Congenital anomalies such as intestinal atresia.<\/li>\n<\/ul>\n<\/li>\n<li>Chemical factors:\n<ul>\n<li>Exposure to toxic substances that affect the intestinal mucosa.<\/li>\n<li>Uncontrolled use of certain medications, such as nonsteroidal anti-inflammatory drugs.<\/li>\n<\/ul>\n<\/li>\n<li>Other factors:\n<ul>\n<li>Inflammatory bowel diseases such as Crohn&#039;s disease.<\/li>\n<li>Infectious diseases that lead to damage to the intestinal mucosa.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of short bowel syndrome involves several stages. The main symptoms to pay attention to are:<\/p>\n<ul>\n<li>Diarrhea with frequent watery stools;<\/li>\n<li>Disruption of growth and development in childhood;<\/li>\n<li>Weight loss and energy deficiency;<\/li>\n<li>Symptoms of vitamin and mineral deficiency.<\/li>\n<\/ul>\n<p>Laboratory tests may include testing for electrolyte levels, vitamin deficiencies, and protein deficiencies. Radiological tests such as X-rays, CT scans, and MRIs help evaluate the bowel and identify potential complications. Other diagnostic tests may include endoscopy to visualize and biopsy the intestinal wall. It is also important to perform a differential diagnosis to rule out other conditions that can cause similar symptoms, such as celiac disease or angry gut syndrome.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of short bowel syndrome includes several approaches aimed at improving quality of life and correcting nutritional disorders:<\/p>\n<ul>\n<li>General treatment:\n<ul>\n<li>Correcting your diet and ensuring adequate calorie intake.<\/li>\n<li>Use of specialized nutritional formulas.<\/li>\n<\/ul>\n<\/li>\n<li>Pharmacological treatment:\n<ul>\n<li>The use of probiotics to improve the state of intestinal microflora.<\/li>\n<li>Using medications to control diarrhea and abdominal pain.<\/li>\n<\/ul>\n<\/li>\n<li>Surgical treatment:\n<ul>\n<li>Bowel transplantation may be necessary in patients with severe forms of SBS.<\/li>\n<li>Elective surgeries to improve the function of the remaining part of the intestine.<\/li>\n<\/ul>\n<\/li>\n<li>Other types of treatment:\n<ul>\n<li>Parenteral nutrition when oral intake is impossible.<\/li>\n<li>Therapy to correct electrolyte disturbances.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Probiotics (eg Lactobacillus GG);<\/li>\n<li>Antidiarrheal drugs (eg, loperamide);<\/li>\n<li>Medicines for pain control (for example, no-shpa);<\/li>\n<li>Vitamin and mineral supplements (eg, vitamin B complex, vitamin D);<\/li>\n<li>Electrolyte solutions to maintain water-electrolyte balance.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with short bowel syndrome includes regular check-ups to assess nutritional status and reduce the risk of vitamin and mineral deficiencies. Monitoring steps may include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Regular laboratory tests for electrolyte and vitamin levels;<\/li>\n<li>Clinical monitoring of weight and height, especially in children;<\/li>\n<li>Assessing the need for correction of diet and nutritional methods;<\/li>\n<li>Determination of the functional state of the remaining intestine using imaging studies.<\/li>\n<\/ul>\n<p>The prognosis for patients with short bowel syndrome varies depending on the extent of the bowel defect and the quality of treatment. Complications can include serious metabolic disturbances and potentially life-threatening conditions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Age-related features of short bowel syndrome manifest themselves differently:<\/p>\n<ul>\n<li>In newborns and infants, the disease is often associated with congenital anomalies or conditions such as necrotizing enterocolitis, which require immediate medical attention.<\/li>\n<li>Older children and adolescents may experience malnutrition and growth retardation.<\/li>\n<li>In adults, short bowel syndrome is most often a consequence of intestinal surgery, which leads to the need for specific dietary therapy methods.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of short bowel syndrome?<\/strong> The main symptoms include diarrhea, weight loss, malnutrition, fatigue and electrolyte imbalances.<\/li>\n<li><strong>How is short bowel syndrome diagnosed?<\/strong> Diagnosis includes clinical assessment of symptoms, laboratory tests, and imaging studies such as EGD and CT.<\/li>\n<li><strong>What treatment is prescribed for patients with this syndrome?<\/strong> Treatment includes diet therapy, pharmacological support, possibly surgery and parenteral nutrition.<\/li>\n<li><strong>What is the prognosis for patients with short bowel syndrome?<\/strong> The prognosis depends on the degree of intestinal contraction and the treatment measures taken; both successful results and the development of serious complications are possible.<\/li>\n<li><strong>What causes short bowel syndrome?<\/strong> The main causes are surgical interventions, congenital anomalies, inflammatory diseases and injuries. <\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Short bowel syndrome (SBS) is a clinical condition caused by a lack of functional intestinal length, resulting in impaired absorption of nutrients and<\/p>","protected":false},"author":1,"featured_media":23105,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12994"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12994\/revisions"}],"predecessor-version":[{"id":13927,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12994\/revisions\/13927"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/23105"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}