{"id":12881,"date":"2024-08-23T08:54:58","date_gmt":"2024-08-23T06:54:58","guid":{"rendered":"https:\/\/valintermed.com\/?p=12881"},"modified":"2024-08-23T08:54:58","modified_gmt":"2024-08-23T06:54:58","slug":"immuno-kostnaya-displaziya-shimke","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/","title":{"rendered":"Schimke&#039;s immunoosseous dysplasia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Shincke immune-bone dysplasia (SKBD) is a rare genetic disorder characterized by abnormal bone formation and regeneration, as well as immune dysfunction. This multisystem disorder results in abnormal bone growth and abnormal immune function, which can progress to serious orthopedic and infectious complications. Important aspects of this dysplasia include vulnerability to infections, osteoporosis, and high fracture risk. It should be noted that SKBD most often manifests itself in childhood and adolescence, which requires careful monitoring and treatment to improve the quality of life of patients.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/immunoosseous-displasia-of-the-shimke\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Schimke&#039;s immunoosseous dysplasia was first described in the 1970s, when researchers began to identify a link between bone disorders and immune system pathologies. Over time, the disease has become the focus of medical researchers, and numerous studies have been conducted to understand its etiology, pathogenesis, and clinical manifestations. Interestingly, many aspects of the disease remain poorly understood to date, creating a platform for further research. The studies have identified isolated cases that have opened new horizons in understanding the genetic mechanisms underlying dysplasia. Perhaps in the future, the emergence of new genomic sequencing technologies will allow a deeper understanding of this disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Data on the incidence of Schimke immunoosseous dysplasia remain limited because the disease is very rare. Only about 200 cases have been reported worldwide to date. Based on available statistics, it can be assumed that the prevalence is approximately 1 case per 1 million live births. It should be noted that there are no consistent indicators of the geographical spread of the disease, indicating its sporadic nature and likely random gene mutation. However, further epidemiological studies are needed to more accurately estimate the prevalence.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Schimke&#039;s immunoosseous dysplasia develops as a result of mutations in genes responsible for bone metabolism and immune system functioning. In particular, the most frequently identified mutations were in the IKBKB gene, which plays a key role in the regulation of inflammatory processes and signal transmission in cells. It was found that these mutations lead to disruption of nuclear factor kappa B (NF-kB) signaling, which, in turn, is associated with the development of autoimmune diseases and osteoporosis in patients with dysplasia. Genetic predisposition to the disease can be hereditary, but in most cases a sporadic form is observed, arising due to new mutations.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The risks of developing Schimke&#039;s immunoosseous dysplasia are associated with both hereditary and environmental factors. The most significant of these include:<\/p>\n<ul>\n<li>Hereditary predisposition \u2013 the presence of cases of this disease in the family;<\/li>\n<li>Environmental factors \u2013 exposure of the mother to radiation and toxic chemicals during pregnancy;<\/li>\n<li>Infectious diseases of the mother during pregnancy, which can affect the development of the fetus;<\/li>\n<li>Alcohol and drugs \u2013 history of maternal drug or alcohol use;<\/li>\n<\/ul>\n<p>The study of these factors is of great importance for understanding the pathogenesis of the disease and subsequent monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of Schimke&#039;s immunoosseous dysplasia involves several stages aimed at establishing a clinical diagnosis and confirming genetic disorders. The main symptoms of the disease are often observed in pediatric practice and include:<\/p>\n<ul>\n<li>Anomalies of growth and development of the skeleton;<\/li>\n<li>Frequent fractures and osteoporosis;<\/li>\n<li>Deformations of the limbs;<\/li>\n<li>Decreased immunity, predisposition to infections;<\/li>\n<\/ul>\n<p>Laboratory tests include a complete blood count, immunoglobulin levels, and antigen tests. Radiological examinations such as X-rays and magnetic resonance imaging (MRI) play a key role in studying the condition of bone tissue. Additional diagnostic methods such as genetic testing can identify mutations associated with the disease. Differential diagnosis is important to exclude other dysplasias and autoimmune disorders.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of Schimke&#039;s immuno-osseous dysplasia should be multifaceted and individualized, taking into account the severity of the patient&#039;s condition and the presence of concomitant diseases. The main areas of treatment include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>General treatment: supportive therapy is aimed at improving the quality of life and preventing infectious diseases;<\/li>\n<li>Pharmacological treatment: use of vitamin D and calcium to maintain healthy bone tissue, as well as immunomodulators to correct the immune response;<\/li>\n<li>Surgical treatment: correction of skeletal deformities and stabilization of fractures;<\/li>\n<li>Physiotherapy and rehabilitation measures: aimed at restoring motor function and improving the general condition of the patient.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The following groups of drugs may be used during the treatment of Schimke&#039;s immunoosseous dysplasia:<\/p>\n<ul>\n<li>Immunomodulators: azathioprine, methotrexate;<\/li>\n<li>Vitamins: vitamin D, calcium;<\/li>\n<li>Drugs to increase bone density: bisphosphonates.<\/li>\n<\/ul>\n<p>Well-chosen treatment can significantly improve the condition of patients and reduce the risk of complications.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with Schimke&#039;s immunoosseous dysplasia includes:<\/p>\n<ul>\n<li>Regular check-ups with an orthopedist and immunologist;<\/li>\n<li>Laboratory tests to monitor levels of inflammatory markers;<\/li>\n<li>Radiological studies to assess the condition of bone tissue;<\/li>\n<\/ul>\n<p>The prognosis of the disease depends on timely diagnosis and the adequacy of the treatment. Complications may include serious infectious processes, fractures and osteoporosis, which require constant monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Schimke&#039;s immuno-osseous dysplasia manifests itself differently depending on the patient&#039;s age. In childhood, the disease can hide under the guise of other pathologies, and often only as the child grows do characteristic signs of bone deformation begin to appear. <\/p>\n<ul>\n<li>In children: frequent fractures, growth retardation, skeletal deformities;<\/li>\n<li>In adolescence: increased risk of infectious diseases, chronic bone pain;<\/li>\n<li>In adults: persistent complications, decreased quality of life due to bone abnormalities and weakened immunity.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of Schimke&#039;s immunoosseous dysplasia?<\/strong> The main symptoms include growth abnormalities, frequent fractures, limb deformities and decreased immunity.<\/li>\n<li><strong>What genetic mutations are associated with this disease?<\/strong> The disease is associated with mutations in the IKBKB gene, which regulates metabolism and immune system function.<\/li>\n<li><strong>What are the treatment methods for this disease?<\/strong> Treatment may include drug therapy, surgery, and physical therapy.<\/li>\n<li><strong>What is the outlook for patients with immunoosseous dysplasia?<\/strong> The prognosis depends on timely diagnosis and treatment, but complications may develop.<\/li>\n<li><strong>What tests are needed to diagnose the disease?<\/strong> Diagnosis includes laboratory tests, radiological examinations and genetic testing.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Shincke immune-bone dysplasia (SKBD) is a rare genetic disorder characterized by impaired bone formation and regeneration, as well as<\/p>","protected":false},"author":1,"featured_media":22850,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12881"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12881\/revisions"}],"predecessor-version":[{"id":14041,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12881\/revisions\/14041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/22850"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}