{"id":12715,"date":"2024-10-11T16:58:41","date_gmt":"2024-10-11T14:58:41","guid":{"rendered":"https:\/\/valintermed.com\/?p=12715"},"modified":"2024-10-11T16:58:41","modified_gmt":"2024-10-11T14:58:41","slug":"feohromotsitoma","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/","title":{"rendered":"Pheochromocytoma"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Pheochromocytoma is a tumor of the adrenal gland characterized by excessive secretion of catecholamines such as epinephrine and norepinephrine. These substances play a key role in regulating the \u201cfight or flight\u201d system, which leads to severe hypertension and a number of other cardiovascular symptoms. Pheochromocytomas can be both benign and malignant, and their features are often due to a genetic predisposition. The main manifestations of the disease include persistent or paroxysmal hypertension, headaches, sweating, and rapid heartbeat. Insufficient diagnosis and treatment of pheochromocytoma can lead to significant complications, including cardiovascular catastrophes.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/feohromotsitoma\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pheochromocytoma was first described in the early 20th century. In 1927, Professor Hugh Bretton attempted to classify adrenaline-producing tumors, which became the basis for future research into the disease. Interestingly, the name pheochromocytoma comes from the Greek words pheo (yellow) and chromo (color), as these tumors are characterized by a yellowish tint when examined histologically. Over the years, many studies have confirmed the association of this tumor with hereditary syndromes such as Li-Fraumeni syndrome and multiple endocrine neoplasia type 2 (MEN 2), which opened up new horizons in understanding the etiology and pathogenesis of pheochromocytomas.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to statistics, pheochromocytoma is a rare disease, with an incidence of 2 to 8 cases per 1 million people per year. Obviously, this disease is more often diagnosed in people aged 30 to 50 years, although pheochromocytomas can occur at any age. According to large studies, more than 75% cases of pheochromocytoma occur in young and middle-aged people. At the same time, women are more likely than men to encounter this pathology, the ratio is approximately 3:2. It is also worth noting that in the case of a hereditary predisposition, the likelihood of the disease increases significantly.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pheochromocytoma may occur within several inherited syndromes. First, certain mutations in the RET, VHL, and NF1 genes may lead to the development of this tumor. For example, mutations in the RET gene are associated with multiple endocrine neoplasia type 2 (MEN 2), which may imply the development of pheochromocytomas. Previous genetic studies have shown that about 25-30% patients with pheochromocytoma have significant genetic mutations, which indicates the importance of genetic testing to determine genetic predisposition. Establishing a family history allows us to identify possible cases of the disease in close relatives and carry out the necessary medical monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are certain risk factors that may contribute to the development of pheochromocytoma. These include:<\/p>\n<ul>\n<li>Heredity: Patients with a family history of pheochromocytoma or related syndromes are at greater risk.<\/li>\n<li>Age. The disease is more common in people aged 30 to 50 years.<\/li>\n<li>Environmental factors: Chemicals such as solvents and some toxins may be associated with increased incidence.<\/li>\n<li>Comorbidities: Certain medical conditions, such as diabetes and cardiovascular disease, may be risk factors.<\/li>\n<\/ul>\n<p>The presence of at least one of these factors may require closer observation and possible medical examination for early detection of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of pheochromocytoma involves several stages. Initially, the patient may complain of the following symptoms:<\/p>\n<ul>\n<li>Hypertension (constant or paroxysmal).<\/li>\n<li>Headaches, which can be severe.<\/li>\n<li>Sweating.<\/li>\n<li>Attacks of palpitations or tachycardia.<\/li>\n<li>Tremor and anxiety.<\/li>\n<\/ul>\n<p>Laboratory tests are critical in diagnosis. They typically include:<\/p>\n<ul>\n<li>Measurement of catecholamine and metanephrine levels in plasma and urine.<\/li>\n<li>Biochemical tests for kidney function and other organs.<\/li>\n<\/ul>\n<p>Radiological examinations such as CT or MRI can visualize the tumor and assess its size and extent. Scintigraphic examination using iodinated metaiodobenzylguanidine (MIBG) can also be performed. Differential diagnosis should be made with other causes of hypertension, such as primary aldosteronism, Cushing&#039;s syndrome, and others. This will help to clarify the diagnosis and begin adequate treatment.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of pheochromocytoma requires a comprehensive approach and may include the following methods:<\/p>\n<ul>\n<li>General treatment: Before surgery, patients often receive antihypertensive medications to control blood pressure and reduce the risk of cardiovascular complications.<\/li>\n<li>Pharmacological treatment: Alpha- and beta-blockers such as phenoxybenzamine and propranolol are used to reduce the effects of catecholamines on the cardiovascular system.<\/li>\n<li>Surgical treatment. The main method is tumor removal, which can be performed open or laparoscopically, depending on the size and location of the pheochromocytoma.<\/li>\n<li>Other treatments: In some cases, radiotherapy or chemotherapy may be recommended to treat metastatic or surgically inaccessible tumors.<\/li>\n<\/ul>\n<p>The effectiveness of treatment largely depends on early detection and adequate preparation of the patient for surgery.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main medications used to control the symptoms of pheochromocytoma and prepare for surgery include:<\/p>\n<ul>\n<li>Phenoxybenzamine is an alpha-blocker used to treat hypertension in pheochromocytoma.<\/li>\n<li>Propranolol is a beta-blocker used to control heart rhythm and reduce symptoms.<\/li>\n<li>Enalapril is an ACE inhibitor and can be used to control hypertension.<\/li>\n<li>Spironolactone - may be prescribed for concomitant hyperaldosteronism.<\/li>\n<\/ul>\n<p>These drugs help to stabilize the patient&#039;s condition both before and after surgery.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of pheochromocytoma involves regular observation of the patient&#039;s condition after surgical treatment. Monitoring steps typically include:<\/p>\n<ul>\n<li>Regular blood pressure measurements.<\/li>\n<li>Laboratory tests of catecholamine and metanephrine levels to assess relapse.<\/li>\n<li>Radiological studies to monitor possible metastatic process.<\/li>\n<\/ul>\n<p>The prognosis with adequate surgical treatment is positive in most cases, but complications such as tumor recurrence or metastases are possible. Complications may also include cardiovascular events, which require systematic patient monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pheochromocytoma can manifest itself differently depending on the patient&#039;s age. In children, this disease is less common, and its diagnosis can be difficult due to the nonspecificity of symptoms. In older patients, the disease can have a more severe course, often associated with concomitant pathologies. Pregnant women are also at risk, as their symptoms may increase due to changes in hormonal levels. Early detection and diagnosis are especially important to prevent serious complications and improve the quality of life of patients of all ages.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of pheochromocytoma?<\/strong> The main symptoms include hypertension, headaches, sweating, palpitations and tremors.<\/li>\n<li><strong>Can pheochromocytoma be treated successfully?<\/strong> Yes, surgical removal of the tumor in most cases leads to a complete recovery, especially with early diagnosis.<\/li>\n<li><strong>Who is at risk for developing pheochromocytoma?<\/strong> The risk group includes people with a hereditary predisposition, as well as patients aged 30 to 50 years.<\/li>\n<li><strong>How is pheochromocytoma diagnosed?<\/strong> Diagnosis includes laboratory tests for catecholamine levels, radiological examinations, and assessment of clinical symptoms.<\/li>\n<li><strong>Is it possible to do without surgical treatment?<\/strong> In most cases, surgical treatment remains the main method, but in special situations, conservative treatment with symptom control is possible.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Pheochromocytoma is a tumor of the adrenal gland characterized by excessive secretion of catecholamines such as epinephrine and norepinephrine. These substances play a key role in<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12715","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12715"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12715\/revisions"}],"predecessor-version":[{"id":14364,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12715\/revisions\/14364"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}