{"id":12588,"date":"2024-10-11T19:00:46","date_gmt":"2024-10-11T17:00:46","guid":{"rendered":"https:\/\/valintermed.com\/?p=12588"},"modified":"2024-10-11T19:00:46","modified_gmt":"2024-10-11T17:00:46","slug":"polimikrogiriya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/","title":{"rendered":"Polymicrogyria"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Polymicrogyria is a neurodevelopmental disorder characterized by abnormal development of the cortical convolutions of the brain, with an increased number and abnormal shapes. This disorder occurs as a result of abnormal neuronal migration during embryonic development, which leads to pathological changes in the structure of the cerebral cortex. Polymicrogyria can manifest itself in a variety of neurological symptoms, including epilepsy, cognitive impairment, motor and sensory disorders, and behavioral abnormalities. The disease can be isolated or associated with other neurological disorders.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/polymicrogiriya\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of polymicrogyria as a clinical entity begins in the mid-20th century, when various researchers began to associate cortical abnormalities with neurological disorders. One of the first descriptions of polymicrogyria in clinical practice was in the works of neurologist Walter Merck, who studied patients with severe neurological disorders in the 1940s. In the 1950s, thanks to the development of neuroimaging, scientists were able to study the cortical abnormalities in detail and deepen their knowledge of the mechanisms behind polymicrogyria. Interestingly, in the 1980s, the first molecular studies were conducted that began to raise questions about the genetic causes of polymicrogyria. In recent decades, it has been established that neuronal migration disorders are largely associated with several genes that are under study.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The epidemiology of polymicrogyria indicates that the disorder occurs in different regions of the world with variable frequency. The prevalence of polymicrogyria among neurological disorders is reported to be between 1 and 2 cases per 1,000,000 population. Data also show that polymicrogyria is more common in people with other neurological disorders such as autism, brain abnormalities, or epilepsy. Children who have had problems during pregnancy, including strokes or intrauterine infections, are most susceptible to the disorder.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Genetic studies indicate that polymicrogyria may be associated with various mutations in a number of genes. In particular, mutations have been found in the following genes: <\/p>\n<ul>\n<li><strong>DCX (Doublecortin)<\/strong> - plays an important role in neuronal migration;<\/li>\n<li><strong>ARX (Aristaless Related Homeobox)<\/strong> - affects the development of various cells of the nervous system;<\/li>\n<li><strong> LIS1 (Lissencephaly 1)<\/strong> - is important in the process of cell adhesion and migration;<\/li>\n<li><strong>GPR56 (G protein-coupled receptor 56)<\/strong> - participates in the development of the cerebral cortex.<\/li>\n<\/ul>\n<p>These genes act as markers for early diagnosis of the disease and may help determine individual risk in children with a family history.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A variety of risk factors may contribute to the development of polymicrogyria. These include:<\/p>\n<ul>\n<li><strong>Physical factors:<\/strong> pathologies during pregnancy, such as injuries, intrauterine infections or gestosis;<\/li>\n<li><strong>Chemical factors:<\/strong> exposure to toxic substances such as alcohol, drugs, or certain medications;<\/li>\n<li><strong>Genetic factors:<\/strong> family history of various neurological disorders;<\/li>\n<li><strong>Environmental factors:<\/strong> the impact of unfavorable environmental conditions during the period of intrauterine development.<\/li>\n<\/ul>\n<p>Understanding the influence of these factors can help prevent the disease and reduce its prevalence.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of polymicrogyria is based on various approaches:<\/p>\n<ul>\n<li><strong>Main symptoms:<\/strong> It is necessary to take into account the presence of epileptic seizures, developmental delays, learning difficulties, and motor disorders;<\/li>\n<li><strong>Laboratory tests:<\/strong> include blood tests to rule out infectious and metabolic diseases;<\/li>\n<li><strong>Radiological examinations:<\/strong> Magnetic resonance imaging (MRI) is the main diagnostic method that allows identifying structural changes in the cortex;<\/li>\n<li><strong>Other types of disease diagnostics:<\/strong> Electroencephalography (EEG) can be used to detect epileptic activity;<\/li>\n<li><strong>Differential diagnosis:<\/strong> Other neurological conditions such as lissencephaly or cortical folding anomalies must be excluded.<\/li>\n<\/ul>\n<p>A thorough diagnosis helps to establish the correct diagnosis and begin active treatment.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of polymicrogyria involves a comprehensive approach:<\/p>\n<ul>\n<li><strong>General treatment:<\/strong> adherence to a correct lifestyle to alleviate clinical manifestations;<\/li>\n<li><strong>Pharmacological treatment:<\/strong> Antiepileptic drugs are used to control seizures and improve quality of life;<\/li>\n<li><strong>Surgical treatment:<\/strong> may be considered for patients with resistant epilepsy;<\/li>\n<li><strong>Other types of treatment:<\/strong> rehabilitation-oriented therapy, including behavioral and long-term support.<\/li>\n<\/ul>\n<p>Complex treatment helps to reduce the symptoms of the disease and improve the functional state of patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are different groups of drugs used to treat polymicrogyria:<\/p>\n<ul>\n<li><strong>Antiepileptic drugs:<\/strong> lamotrigine, levetiracetam, valproic acid;<\/li>\n<li><strong>Cognitive function stimulants:<\/strong> drugs that improve attention and memory, such as modafinil;<\/li>\n<li><strong>Psychotropic drugs:<\/strong> for the correction of behavioral disorders.<\/li>\n<\/ul>\n<p>The intensity and choice of drugs are determined individually depending on the clinical picture.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring the condition of patients with polymicrogyria is extremely important:<\/p>\n<ul>\n<li><strong>Control stages:<\/strong> regular check-ups with a neurologist and psychiatrist;<\/li>\n<li><strong>Forecast:<\/strong> the severity of symptoms may vary, reflecting the individual prognosis;<\/li>\n<li><strong>Complications:<\/strong> may include cognitive impairment and social isolation.<\/li>\n<\/ul>\n<p>Disease monitoring provides individualized approaches to improving patients&#039; quality of life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Age-related characteristics of the disease vary:<\/p>\n<ul>\n<li><strong>Newborns and small children:<\/strong> may manifest as severe forms of neurological disorders from the first days of life;<\/li>\n<li><strong>Children of primary and school age:<\/strong> delays in learning and problems with social adaptation are often observed;<\/li>\n<li><strong>Teenagers:<\/strong> may experience psycho-emotional difficulties, requiring special attention in educational institutions;<\/li>\n<li><strong>Adults:<\/strong> may experience chronic neurological problems and the need for long-term therapy.<\/li>\n<\/ul>\n<p>Each age group requires careful monitoring and treatment approach.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is polymicrogyria?<\/strong><br \/>\nPolymicrogyria is an anomaly in the development of the cerebral cortex, manifested by an abnormal increase in the number of convolutions and a disruption of their structure.<\/li>\n<li><strong>What methods are used to diagnose polymicrogyria?<\/strong><br \/>\nFor diagnosis, MRI, EEG, and clinical studies for the presence of neurological disorders are used.<\/li>\n<li><strong>What treatment is recommended for patients with polymicrogyria?<\/strong><br \/>\nTreatment may include medications, surgery, and rehabilitation depending on the clinical picture.<\/li>\n<li><strong>What are the possible complications of polymicrogyria?<\/strong><br \/>\nPotential complications include epilepsy, developmental delays, adaptation problems and psychoemotional disorders.<\/li>\n<li><strong>Can polymicrogyria be hereditary?<\/strong><br \/>\nYes, there are genetic predispositions, and some mutations can be inherited.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Polymicrogyria is a neurodevelopmental disorder characterized by abnormal development of the cortical convolutions of the brain, in which there is an increased number of them and abnormal<\/p>","protected":false},"author":1,"featured_media":22111,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12588","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12588"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12588\/revisions"}],"predecessor-version":[{"id":14491,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12588\/revisions\/14491"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/22111"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}