{"id":12564,"date":"2024-10-11T19:32:21","date_gmt":"2024-10-11T17:32:21","guid":{"rendered":"https:\/\/valintermed.com\/?p=12564"},"modified":"2024-10-11T19:32:21","modified_gmt":"2024-10-11T17:32:21","slug":"piknodizostoz","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/pyknodizostoz\/","title":{"rendered":"Pycnodysostosis"},"content":{"rendered":"
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Pycnodysostosis (pycnodysostotic dysplasia) is a rare disorder of bone development characterized by abnormal bone formation and low bone mineral density, making bones more fragile and susceptible to fracture. The disease is caused by abnormalities in osteoblast metabolism, which can lead to abnormalities in bone length and shape, changes in the skull and spine, and altered amounts of fat in the bones. These changes can significantly affect the quality of life of patients, leading to a variety of clinical manifestations, including bone deformities, limited mobility, and persistent pain symptoms. Pycnodysostosis often manifests in childhood and can have a progressive course, requiring a comprehensive approach to diagnosis and treatment.<\/p>\n

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