{"id":12557,"date":"2024-10-11T19:35:46","date_gmt":"2024-10-11T17:35:46","guid":{"rendered":"https:\/\/valintermed.com\/?p=12557"},"modified":"2024-10-11T19:35:46","modified_gmt":"2024-10-11T17:35:46","slug":"pernitsioznaya-anemiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/","title":{"rendered":"Pernicious anemia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Pernicious anemia is a type of megaloblastic anemia characterized by a deficiency of vitamin B12, which in turn occurs due to a violation of its absorption in the body. The main cause of this disorder is atrophic gastritis or autoimmune damage to stomach cells, which leads to a decrease in the synthesis of intrinsic factor - a special protein necessary for the absorption of vitamin B12. Pernicious anemia is manifested by symptoms associated with a lack of hemoglobin, such as fatigue, weakness, pallor, as well as neurological disorders such as paresthesia and impaired coordination. Diagnosis and treatment of this disease are of great importance, since the unavailability of vitamin B12 can cause irreversible changes in the nervous system and other organs.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pernitsiosis-anemia\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pernicious anemia was first described in medical literature in the 19th century, but its symptoms had been known for a long time before that. In 1849, Scottish physician James Blimmen first noted a link between anemia and the need for certain nutrients. In 1926, American physician George Rosenberg and his colleagues successfully conducted experiments that demonstrated that the liver was the source of \u201cthat substance,\u201d which was later identified as vitamin B12. This discovery was crucial in understanding the mechanism by which pernicious anemia develops. By the end of the 20th century, diagnostic and treatment methods had been developed, including vitamin B12 injections, which radically changed the approach to treating this condition. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The prevalence of pernicious anemia varies by population and region. According to a study conducted in the United States, its incidence is approximately 0.1-0.2% in the general population. However, in people over 60 years of age, this figure increases to 5-10%. Other studies show that pernicious anemia is more common in women than in men, with a ratio of 3:1. The disease has also been found to have a higher prevalence in people with certain gastrointestinal disorders and autoimmune diseases. In some areas where there is a deficiency of vitamin B12 in the diet, the incidence rates may be higher.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research suggests that some genetic factors may contribute to the development of pernicious anemia. The gene encoding the intrinsic factor protein is located on chromosome 11, and mutations affecting its synthesis have been identified. The autoimmune process underlying the disease may be due to the presence of certain HLA genes (major histocompatibility complex genes), such as HLA-DR5 and HLA-DR6, which predisposes patients to autoimmune diseases. Research suggests that a family history of pernicious anemia or other autoimmune diseases may serve as a marker of increased risk. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main risk factors for the development of pernicious anemia include:<\/p>\n<ul>\n<li>Age - the incidence increases after 50 years;<\/li>\n<li>Autoimmune diseases - the presence of other autoimmune conditions (eg, Hashimoto&#039;s thyroiditis);<\/li>\n<li>Familial predisposition - cases of the disease in the family;<\/li>\n<li>Gastrointestinal disorders - such as chronic atrophic gastritis or celiac disease;<\/li>\n<li>Use of certain medications - proton pump inhibitors, metformin, etc.<\/li>\n<\/ul>\n<p>The influence of these factors on the development of pernicious anemia emphasizes the importance of timely diagnosis and prevention in individuals at increased risk.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of pernicious anemia involves several stages, starting with clinical assessment and ending with laboratory tests. The main symptoms of the disease are:<\/p>\n<ul>\n<li>Fatigue and weakness;<\/li>\n<li>Pale skin;<\/li>\n<li>Neurological disorders - paresthesia, impaired coordination;<\/li>\n<li>Cardiovascular symptoms: tachycardia, shortness of breath.<\/li>\n<\/ul>\n<p>Laboratory tests play a key role and include:<\/p>\n<ul>\n<li>General blood test - decreased hemoglobin and hematocrit levels, increased size of red blood cells (macrocytosis);<\/li>\n<li>Vitamin B12 levels - low values indicate deficiency;<\/li>\n<li>A test for anti-intrinsic factor content - a positive result confirms the diagnosis.<\/li>\n<\/ul>\n<p>Radiological studies are not mandatory for diagnosis, but may be indicated in the presence of diseases that potentially affect the absorption of vitamin B12. Differential diagnosis should be made with other types of anemia and diseases characterized by anemia syndrome.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of pernicious anemia involves replenishing the vitamin B12 deficiency, which can be done in various ways. The main approaches to therapy are:<\/p>\n<ul>\n<li>General treatment involves giving vitamin B12 by injection or orally;<\/li>\n<li>Pharmacological treatment - use of cobalamin in dosages depending on the degree of deficiency;<\/li>\n<li>Surgical treatment may be required if concomitant diseases such as tumors or gastric obstructions are detected;<\/li>\n<li>Other treatments are aimed at correcting associated conditions and providing supportive care.<\/li>\n<\/ul>\n<p>It is important to follow your doctor&#039;s recommendations and monitor your vitamin B12 levels during treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat pernicious anemia include:<\/p>\n<ul>\n<li>Cobalamin (vitamin B12) - in injectable or oral form;<\/li>\n<li>Folic acid - in some cases to prevent defects in cell division;<\/li>\n<li>Supportive drugs - it is possible to use iron preparations in case of its deficiency;<\/li>\n<li>Immunomodulators - in case of an autoimmune component of the disease.<\/li>\n<\/ul>\n<p>The choice of specific drugs and their dosage depends on the patient\u2019s condition and individual characteristics.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with pernicious anemia includes regular control studies of vitamin B12 levels and complete blood count. Clinical symptoms are expected to improve within weeks with treatment. The prognosis is generally favorable with timely diagnosis and adequate treatment. Complications include the development of neurological disorders with long-term vitamin B12 deficiency and cardiovascular problems, so timely prevention and treatment are essential.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pernicious anemia is more common in older people due to age-related changes in the gastrointestinal tract and decreased production of intrinsic factor. Older people may also have more pronounced clinical symptoms, including neurological manifestations. In children and young adults, the disease may not manifest itself as clearly, but it is important to monitor for hereditary predisposition and symptoms that indicate vitamin B12 deficiency.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is pernicious anemia?<\/strong> - This is a type of anemia caused by a deficiency of vitamin B12, which results in a lack of red blood cells and can cause neurological problems.<\/li>\n<li><strong>How to diagnose pernicious anemia?<\/strong> \u2014 Diagnostics include a complete blood count, vitamin B12 levels, and an anti-intrinsic factor test.<\/li>\n<li><strong>How is pernicious anemia treated?<\/strong> \u2014 Treatment is based on the administration of vitamin B12, both in injection and oral form.<\/li>\n<li><strong>What are the risk factors for pernicious anemia?<\/strong> \u2014 These include age, the presence of autoimmune diseases and gastritis, as well as genetic predisposition.<\/li>\n<li><strong>What is the prognosis for pernicious anemia?<\/strong> \u2014 With timely treatment, the prognosis is usually favorable, but it is important to monitor vitamin B12 levels to prevent complications.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Pernicious anemia is a type of megaloblastic anemia characterized by a deficiency of vitamin B12, which in turn occurs due to a disturbance in its absorption<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12557","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12557","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12557"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12557\/revisions"}],"predecessor-version":[{"id":14522,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12557\/revisions\/14522"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12557"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12557"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12557"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}