{"id":12553,"date":"2024-10-11T19:37:53","date_gmt":"2024-10-11T17:37:53","guid":{"rendered":"https:\/\/valintermed.com\/?p=12553"},"modified":"2024-10-11T19:37:53","modified_gmt":"2024-10-11T17:37:53","slug":"perifericheskaya-t-kletochnaya-limfoma","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/","title":{"rendered":"Peripheral T-cell lymphoma"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of malignant lymphoid diseases that originate from T cells found in the peripheral lymphatic system. This form of lymphoma can present in a variety of clinical forms and may involve various organs, including the skin, lymph nodes, and viscera. PTCL often presents with an aggressive course and has a poor survival rate compared to other types of lymphoma, such as B-cell lymphomas. Key features of the disease are the variability of the clinical presentation, the presence of different subtypes, and the difficulty in diagnosis and treatment. <\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripheral-cellular-lymphoma\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of peripheral T-cell lymphoma began in the mid-20th century, when researchers began to differentiate lymphoma subtypes and classify them based on their cellular composition. In 1975, the first classification was proposed, which included separating T-cell lymphomas from B-cell lymphomas. An important step in the study of PTCL was the use of immunohistochemistry to determine the cell type, which significantly improved diagnostics. During this time, various subtypes were described, such as angiosarcoma, Sezary lymphoma, and others, which also contributed to a better understanding of these diseases. As molecular genetics developed, various mutations and abnormalities were identified, confirming the complexity and diversity of PTCL. Each discovery in this area helped to form a deeper understanding of the pathogenesis of the disease and became the basis for the development of targeted therapies.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to statistics, PTCL accounts for approximately 10-15% of all non-Hodgkin lymphoma cases. The incidence rate varies by geographic region and gender. The average age at diagnosis is 55-60 years, but PTCL can also occur in younger patients. Studies report that the incidence is higher in men than in women, with a ratio of 2:1. Given that lymphomas often occur in the setting of immunodeficiency, some studies show an increased incidence among patients with HIV\/AIDS and other conditions that weaken the immune system. There has been an increase in the incidence of PTCL in recent decades, likely due to improved diagnosis and increased awareness.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research shows that certain genetic mutations and chromosomal abnormalities play a key role in the pathogenesis of peripheral T-cell lymphoma. Among the most frequently observed changes are mutations in genes associated with cell cycle regulation, as well as T-cell proliferation and differentiation. Among them are:<\/p>\n<ul>\n<li>Mutations in the TP53 gene, which is responsible for cell cycle control<\/li>\n<li>Chromosomal deletion 5q<\/li>\n<li>Dysregulation of BCL-2 and BCL-6 genes<\/li>\n<li>Abnormalities in chromosome 8q24 associated with MYC<\/li>\n<li>Genetic changes associated with TCR (T-cell receptor)<\/li>\n<\/ul>\n<p>Understanding genetic changes is important for developing targeted therapy and predicting the course of the disease. Thus, genetic predisposition plays a significant role in the occurrence and progression of PTCL.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors for developing peripheral T-cell lymphoma are varied and may include physical and chemical exposures as well as certain medical conditions. Major risk factors include:<\/p>\n<ul>\n<li>Immunodeficiency states, including HIV infection and organ transplantation<\/li>\n<li>Long-term immunosuppressive therapy, such as after organ transplantation<\/li>\n<li>Exposure to chemicals such as pesticides and solvents<\/li>\n<li>Infectious agents including Epstein-Barr virus and cytomegalovirus<\/li>\n<li>Hereditary predisposition; history of lymphoma in the family<\/li>\n<\/ul>\n<p>Monitoring these risk factors is important for early diagnosis and prevention of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of peripheral T-cell lymphoma involves several key steps, starting with a full clinical examination and ending with specialized laboratory and radiological studies. Key symptoms may include:<\/p>\n<ul>\n<li>Enlarged lymph nodes<\/li>\n<li>Fever and night sweats<\/li>\n<li>Weight loss and weakness<\/li>\n<li>Skin manifestations including itching and skin lesions<\/li>\n<\/ul>\n<p>Laboratory tests include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Clinical blood tests \u2013 to determine the general condition and possible anemia<\/li>\n<li>Immunohistochemical studies \u2013 to identify the cell type<\/li>\n<li>Cytogenetic analysis \u2013 to detect chromosomal abnormalities<\/li>\n<\/ul>\n<p>Radiological examinations such as ultrasound, CT, and MRI help determine the extent of the disease. Differential diagnosis is important to rule out other lymphoma subtypes and diseases such as Hodgkin&#039;s disease and other immune system disorders.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for peripheral T-cell lymphoma depends on many factors, including the subtype of lymphoma, the stage of the disease, and the patient&#039;s overall health. It may include:<\/p>\n<ul>\n<li>Chemotherapy: Usually a combination of drugs effective against T-cell lymphomas, such as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone) is used.<\/li>\n<li>Radiation therapy: may be used as an adjuvant treatment or in case of localized forms of the disease.<\/li>\n<li>Immunotherapy: New drugs such as checkpoint inhibitors (eg, nivolumab) and CAR-T cells are showing promising results.<\/li>\n<li>Surgery: May be considered if the lymphoma is localized and resectable.<\/li>\n<\/ul>\n<p>Each treatment plan is developed individually, taking into account all the characteristics of the disease, and it is important to monitor the response to therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat peripheral T-cell lymphoma include:<\/p>\n<ul>\n<li>Doxorubicin<\/li>\n<li>Cyclophosphamide<\/li>\n<li>Vincristine<\/li>\n<li>Prednisolone<\/li>\n<li>Epothilone<\/li>\n<li>Bendamustine<\/li>\n<li>Checkpoint inhibitors (eg, nivolumab)<\/li>\n<li>CAR-T cells<\/li>\n<\/ul>\n<p>The choice of drug depends on the lymphoma subtype and the stage of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of peripheral T-cell lymphoma involves regular follow-up examinations to assess the response to treatment and detect possible relapses. The prognosis of the disease depends on many factors, including the stage and the initial response to therapy:<\/p>\n<ul>\n<li>Relapses occur in a significant proportion of patients, requiring a revision of therapy.<\/li>\n<li>Complications may include infections due to immunosuppression and side effects from chemotherapy.<\/li>\n<li>Long-term prognosis can vary, but is generally considered poor, especially in aggressive subtypes.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Peripheral T-cell lymphoma may present differently in different age groups. Patients over 60 years of age tend to have a more aggressive course of the disease and a worse prognosis. At the same time, younger patients may show a more reactive isolation and a positive response to treatment. The presence of concomitant diseases and comorbid conditions also influences the approach to treatment and its outcome.* <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of peripheral T-cell lymphoma?<\/strong> Includes swollen lymph nodes, fever, night sweats, weight loss, and skin manifestations.<\/li>\n<li><strong>How is PTCL diagnosed?<\/strong> Diagnosis includes clinical examination, laboratory tests, immunohistochemistry and radiological methods.<\/li>\n<li><strong>What treatment methods are available?<\/strong> Treatment may include chemotherapy, immunotherapy, radiation therapy, and surgery.<\/li>\n<li><strong>What is the prognosis for PTCL?<\/strong> The prognosis depends on the stage of the disease, but in most cases it is considered unfavorable.<\/li>\n<li><strong>How is the disease monitored?<\/strong> Regular follow-up examinations are necessary to assess the response to treatment and to detect possible relapses.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of malignant lymphoid diseases that originate from T cells found in the peripheral lymphatic system.<\/p>","protected":false},"author":1,"featured_media":21928,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12553","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12553"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12553\/revisions"}],"predecessor-version":[{"id":14526,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12553\/revisions\/14526"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21928"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}