{"id":12551,"date":"2024-10-11T19:38:50","date_gmt":"2024-10-11T17:38:50","guid":{"rendered":"https:\/\/valintermed.com\/?p=12551"},"modified":"2024-10-11T19:38:50","modified_gmt":"2024-10-11T17:38:50","slug":"peripartalnaya-kardiomiopatiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/","title":{"rendered":"Peripartum cardiomyopathy"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Peripartum cardiomyopathy (PPM) is a form of cardiomyopathy that develops in the last months of pregnancy or during the first month after delivery. This disease is characterized by progressive heart failure and in some cases may be associated with arrhythmias. The mechanisms leading to the development of PPM are still not fully understood, but they are believed to include both genetic predisposition and the influence of unfavorable environmental factors, such as infection, stress, and immune-mediated processes. Clinical manifestations of PPM include shortness of breath, fatigue, edema, and decreased overall physical activity. It is important to note that peripartum cardiomyopathy can develop in women without previous cardiovascular diseases, which emphasizes the importance of early diagnosis and timely treatment.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/peripartum-cardiomyopathy\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Peripartum cardiomyopathy was first described in the medical literature in the 1930s, but it has only been studied more widely in recent decades. Research has shown that the condition has a pervasive impact on the health of women and newborns. While the understanding of PCM has changed over time, physicians and researchers have discovered new aspects of the condition due to advances in echocardiography and other diagnostic techniques. Notably, many cultures have a high incidence of the condition among pregnant women with no clear etiology, suggesting that both genetic and cultural factors may play a role in the development of the condition. In some cases, research has confirmed the existence of random mutations in certain genes associated with cardiac pathologies among women with PCM.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to research data, the prevalence of peripartum cardiomyopathy is about 1 in 3,000 - 1 in 4,000 births. However, depending on the region, the incidence data may fluctuate, which is partly explained by genetic characteristics of populations and differences in access to health care. Certain groups have a higher risk of developing PCM, in particular women who are overweight, have multiple pregnancies, or have a history of heart disease. Since the 2000s, there has been an increase in attention to this condition both in medical practice and among the public, which may also affect the statistics of registration of cases of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research suggests that genetic predisposition may play an important role in the development of peripartum cardiomyopathy. Some of the genes involved include:<\/p>\n<ul>\n<li>TTN is a gene encoding titin, a structural protein of the cardiac muscle;<\/li>\n<li>MYH7 is a beta-myosin related gene;<\/li>\n<li>LMNA is a gene responsible for laminins, which are included in the structure of cell nuclei.<\/li>\n<\/ul>\n<p>These genes can undergo mutations and altered expression, which may lead to increased vulnerability of the heart muscle to damaging factors. In addition, differences in the frequency of these mutations are observed in different populations, which may indicate their impact on the development of PCM.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are several risk factors that contribute to the development of peripartum cardiomyopathy:<\/p>\n<ul>\n<li>Multiple pregnancy;<\/li>\n<li>High blood pressure (hypertension) before or during pregnancy;<\/li>\n<li>Severe stress or significant physical exertion;<\/li>\n<li>Infectious diseases suffered during pregnancy;<\/li>\n<li>History of previous cardiovascular diseases;<\/li>\n<li>Smoking or alcohol abuse.<\/li>\n<\/ul>\n<p>The presence of several of these factors simultaneously can significantly increase the risk of developing PCM and complicate the course of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of peripartum cardiomyopathy includes:<\/p>\n<ul>\n<li>The main symptoms are shortness of breath, swelling, fatigue and palpitations.<\/li>\n<li>Laboratory tests, such as blood tests to measure natriuretic peptide levels.<\/li>\n<li>Radiological examinations including echocardiography to assess cardiac function and detect left ventricular dysfunction.<\/li>\n<li>Other diagnostic tests, such as cardiac MRI, if available.<\/li>\n<li>Differential diagnosis with other cardiac diseases such as myocarditis and coronary heart disease.<\/li>\n<\/ul>\n<p>These methods allow us to establish a diagnosis and assess the severity of the disease, which is critical for choosing the optimal treatment. <\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of peripartum cardiomyopathy involves several approaches:<\/p>\n<ul>\n<li>General treatment includes lifestyle changes such as limiting physical activity and following a special diet;<\/li>\n<li>Pharmacological treatment aimed at improving cardiac function and reducing symptoms - beta blockers and diuretics may be used;<\/li>\n<li>Surgical treatment in rare cases if drug therapy is ineffective;<\/li>\n<li>Other treatments, such as rehabilitation to improve cardiovascular function.<\/li>\n<\/ul>\n<p>Effective treatment requires a multidisciplinary approach and constant monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Medications used to treat peripartum cardiomyopathy include:<\/p>\n<ul>\n<li>Beta blockers: metoprolol, carvedilol;<\/li>\n<li>Diuretics: furosemide;<\/li>\n<li>ACE inhibitors: enalapril;<\/li>\n<li>Antiarrhythmic drugs: amiodarone (if necessary).<\/li>\n<\/ul>\n<p>These medications help control symptoms and improve the quality of life of patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with peripartum cardiomyopathy involves regular visits to the doctor, feasible tests and reflects the following aspects:<\/p>\n<ul>\n<li>Control stages: regular echocardiography to assess heart function;<\/li>\n<li>Prognosis: Most women with PCM experience full or partial recovery of cardiac function, but in some cases chronic heart disease may develop;<\/li>\n<li>Complications: high risk of thrombosis and other cardiovascular events.<\/li>\n<\/ul>\n<p>Timely seeking of medical help can significantly improve the prognosis for the life and health of women.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Peripartum cardiomyopathy is more common in young women, but it also occurs in older age groups. Compared to younger women, older patients may have a more severe course of the disease, which is associated with the presence of concomitant diseases and greater risks of cardiovascular disorders. Due to physiological and hormonal characteristics, different age groups may cause different clinical manifestations and change approaches to treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is peripartum cardiomyopathy?<\/strong> This is a form of cardiomyopathy that develops in the last months of pregnancy or during the first month after birth, characterized by heart failure.<\/li>\n<li><strong>What are the symptoms typical for PCM?<\/strong> The main symptoms include shortness of breath, swelling, fatigue, increased heart rate and decreased exercise tolerance.<\/li>\n<li><strong>What are the main risk factors for the disease?<\/strong> Major risk factors include multiple pregnancies, hypertension, infections, a history of cardiovascular disease, and certain genetic factors.<\/li>\n<li><strong>How is PCM diagnosed?<\/strong> Diagnosis includes assessment of clinical symptoms, laboratory tests, echocardiography and, in some cases, cardiac MRI.<\/li>\n<li><strong>What treatment is prescribed for PCM?<\/strong> Treatment may include lifestyle changes, drug therapy (beta blockers, diuretics), rehabilitation and, in exceptional cases, surgery.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Peripartum cardiomyopathy (PPM) is a form of cardiomyopathy that develops in the last months of pregnancy or during the first month after delivery.<\/p>","protected":false},"author":1,"featured_media":21918,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12551"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12551\/revisions"}],"predecessor-version":[{"id":14528,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12551\/revisions\/14528"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21918"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}