{"id":12548,"date":"2024-10-11T19:40:11","date_gmt":"2024-10-11T17:40:11","guid":{"rendered":"https:\/\/valintermed.com\/?p=12548"},"modified":"2024-10-11T19:40:11","modified_gmt":"2024-10-11T17:40:11","slug":"periodicheskoe-rasstroystvo-dvizheniy-konechnostey","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/","title":{"rendered":"Periodic limb movement disorder"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Periodic limb movement disorder (PLMD) is a neurological condition characterized by irregular, often uncontrollable movements of the limbs that occur at rest or during sleep. The disorder can significantly impair the quality of life of patients, causing severe distress and interfering with normal functioning in everyday life. Movements characteristic of the disorder include jerking, flexing, or extending of the limbs. Although the mechanisms by which they occur are not yet fully understood, there is a direct link between PLMD and certain neurological and psychiatric conditions, such as restless legs syndrome and sleep disorders.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/periodic-disorder-of-limb-movement\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Historically, symptoms that we might now characterize as periodic limb movement disorder have been documented in medical texts as early as the 16th century. One of the first descriptions of similar symptoms comes from the works of famous physicians such as Hippocrates, who reported unusual limb movements in his patients. However, the term \u201cperiodic limb movement disorder\u201d was introduced into medical practice relatively recently, in the 20th century. In the 1980s, scientists began to identify this condition as an independent disorder based on observations of patients with sleep disorders. Interestingly, clinical studies conducted in the 2000s revealed a link between periodic limb movement disorder and other neurological diseases such as Parkinson\u2019s disease, which further increased interest in this pathology.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Epidemiological studies have shown that the prevalence of periodic limb movement disorder varies by population and age group. In general populations, the incidence ranges from 2% to 15%, while in people over 65 years of age, this figure can reach 10-20%. Higher incidence rates have also been found in patients with neurological disorders such as chronic kidney disease or restless legs syndrome. Thus, according to research data, among patients with restless legs syndrome in one of the groups, the incidence of PLMD was up to 30%. According to recent data, periodic limb movement disorder is also observed in the elderly, which requires further research to understand the boundaries of this disease in different age groups.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There is evidence to suggest a possible genetic predisposition to periodic limb movement disorder. Genetic studies have identified a number of genes that may play a role in the disorder. Among the genes involved are MEIS1, BTBD9, and PTPRD. For example, mutations in the BTBD9 gene are associated with an increased risk of developing the condition. Some studies have also reported a family history of PTPRD, suggesting that genetic factors may play a role in its development. However, much remains unclear, and further research is needed to elucidate the full mechanisms of gene-environment interactions that lead to the disorder.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are various risk factors that may contribute to the development of periodic limb movement disorder. Physical risk factors include:<\/p>\n<ul>\n<li>Sedentary lifestyle.<\/li>\n<li>Chronic conditions such as restless legs syndrome, kidney disease and neurological disorders.<\/li>\n<li>Metabolic problems, including iron deficiency.<\/li>\n<\/ul>\n<p>Chemical risk factors may include:<\/p>\n<ul>\n<li>Certain medications, such as antidepressants and antihistamines.<\/li>\n<li>Alcohol and drugs.<\/li>\n<li>Smoking and exposure to toxic substances.<\/li>\n<\/ul>\n<p>In addition, stress and lack of sleep are also considered significant predisposing factors for the development of PD, which emphasizes the importance of maintaining a stable psycho-emotional state and hygiene habits.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of periodic limb movement disorder is based on clinical observation and the patient&#039;s medical history. The main symptoms that are observed include:<\/p>\n<ul>\n<li>Involuntary movements of the limbs that occur mainly at rest.<\/li>\n<li>Increased physical activity at night.<\/li>\n<li>Discomfort or anxiety before starting to move.<\/li>\n<\/ul>\n<p>Laboratory tests may include blood tests to determine iron levels and check kidney and thyroid function. Radiological tests, such as MRI, may help rule out other neurological conditions, but there are no specific imaging tests for PDK. The differential diagnosis should include conditions such as Parkinson&#039;s disease, restless legs syndrome, and other movement disorders.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for periodic limb movement disorder can be complex and individualized for each patient. General treatment includes lifestyle changes, such as regular physical activity and improved sleep patterns. Pharmacological treatment may include medications such as dopaminergic antiparkinsonian agents, such as levodopa and bromocriptine, as well as antipsychotics and sedatives. Surgery is considered in rare cases of severe disease when medications fail to produce the desired result. In some cases, physical therapy and alternative methods such as acupuncture may also be used, which may help improve the patient&#039;s condition.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Levodopa.<\/li>\n<li>Bromocriptine.<\/li>\n<li>Progesterone.<\/li>\n<li>Gabapentin.<\/li>\n<li>Dopamine agonists.<\/li>\n<li>Sedatives (eg, amipride). <\/li>\n<li>Antidepressants (in some cases).<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring the condition of periodic limb movement disorder involves regular consultations with a doctor and monitoring the dynamics of symptoms. Control stages can be carried out at intervals of several months to assess the effectiveness of treatment and the need for its adjustment. The prognosis of the disease varies; in most patients, symptoms can be successfully controlled with the help of proper treatment. However, in some cases, complications such as depression and sleep disorders may be observed, which also require attention.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Periodic limb movement disorder may present differently in different age groups. In younger adults, the disorder may present more severely, often accompanied by restless legs syndrome. Older patients often have less severe symptoms but more severe consequences for quality of life, such as insomnia and fatigue. In children, symptoms may be related to growth and development, requiring specialized care and attention from pediatricians.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is periodic limb movement disorder?<\/strong><br \/>\nIt is a neurological condition characterized by irregular and uncontrolled movements of the limbs that may occur at rest or during sleep.<\/li>\n<li><strong>What are the main symptoms of the disease?<\/strong><br \/>\nThe main symptoms include involuntary movements of the limbs, anxiety before starting movements, and increased physical activity at night.<\/li>\n<li><strong>How is the disease diagnosed?<\/strong><br \/>\nDiagnosis is based on medical history, clinical symptoms, laboratory tests and exclusion of other diseases through radiological methods.<\/li>\n<li><strong>Is there a drug treatment?<\/strong><br \/>\nYes, there are medications such as levodopa and bromocriptine, as well as sedatives and antidepressants that can be used to treat this condition.<\/li>\n<li><strong>What is the prognosis and possible complications of the disease?<\/strong><br \/>\nThe prognosis varies, and many patients can control symptoms with treatment, but complications such as chronic depression and sleep disturbances are possible.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Periodic limb movement disorder (PLMD) is a neurological condition characterized by irregular, often uncontrollable movements of the limbs that occur at rest or<\/p>","protected":false},"author":1,"featured_media":21904,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12548","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12548","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12548"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12548\/revisions"}],"predecessor-version":[{"id":14531,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12548\/revisions\/14531"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21904"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12548"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12548"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12548"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}