{"id":12522,"date":"2024-10-11T20:13:30","date_gmt":"2024-10-11T18:13:30","guid":{"rendered":"https:\/\/valintermed.com\/?p=12522"},"modified":"2024-10-11T20:13:30","modified_gmt":"2024-10-11T18:13:30","slug":"pervichnaya-giperoksaluriya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/primary-hyperoxaluria\/","title":{"rendered":"Primary hyperoxaluria"},"content":{"rendered":"
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Primary hyperoxaluria (PH) is a rare inherited disorder characterized by abnormal calcium and oxalate metabolism, resulting in high levels of oxalate in the urine. Excessive excretion of oxalate can lead to the formation of oxalate kidney stones and can cause kidney damage, especially if left untreated. The underlying mechanism for the development of this pathology is related to defects in oxalate metabolism, which leads to its excessive production in the liver. There are different types of primary hyperoxaluria, of which types 1 and 2 are the most common, caused by mutations in the corresponding genes involved in oxalate metabolism.<\/p>\n

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