{"id":12471,"date":"2024-10-11T20:59:20","date_gmt":"2024-10-11T18:59:20","guid":{"rendered":"https:\/\/valintermed.com\/?p=12471"},"modified":"2024-10-11T20:59:20","modified_gmt":"2024-10-11T18:59:20","slug":"legochnyy-nadklapannyy-stenoz","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/","title":{"rendered":"Pulmonary supravalvular stenosis"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Pulmonary supravalvular stenosis (PSVS) is a narrowing of the right ventricular outflow tract that prevents normal blood flow from the heart to the lungs. This condition can be either congenital or acquired and is characterized by increased pressure in the right ventricle, which in turn leads to its hypertrophy. PVS can be accompanied by various clinical manifestations, including shortness of breath, fatigue, chest pain, and syncope. The temporary progression of the disease often leads to serious complications, including heart failure and dangerous arrhythmias, which requires an objective clinical approach and timely intervention.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-adhesion-stenosis\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pulmonary supravalvular stenosis as a clinical problem was first described in the mid-20th century, but its study began much earlier. In the 1940s, some cardiologists began to associate anomalies of the supravalvular structures with already known congenital heart defects. Interestingly, in their initial studies, they noted the similarity of symptoms and anatomical changes observed in patients with pulmonary stenosis and other cardiovascular diseases. In 1963, M. M. Kostyan and his colleagues performed the first successful operation to correct pulmonary stenosis, which opened new horizons in cardiac surgery. The first advances in the use of computed tomography and echocardiography in the 1990s changed approaches to the diagnosis and treatment of this condition, allowing for timely identification of stenosis and individualization of surgical intervention methods.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>It is assumed that pulmonary supravalvular stenosis occurs in the population in approximately 5-10% patients with congenital heart defects, which makes it a fairly common disease. According to studies, among patients with pulmonary stenosis, about 80% cases are isolated, while 20% patients suffer from a combination with other cardiovascular anomalies. The frequency of occurrence of the disease varies depending on the population, and there is also a gender predisposition - pulmonary stenosis is detected in boys two to three times more often than in girls. Considering all of the above, pulmonary supravalvular stenosis is a fairly common diagnosis in cardiology and requires careful monitoring from the early years of the patient&#039;s life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pulmonary supravalvular stenosis has a genetic basis, especially when it is inherited as part of syndromes such as Turner syndrome, cardiogenetic syndrome or Phoenix syndrome. Studies of the genetic factors causing this condition have identified important mutations in certain genes such as NOTCH1 and MYH11, which are associated with the development of cardiovascular anomalies. It has been shown that patients with a family history of pulmonary stenosis have a higher incidence of this disease, which emphasizes its genetic nature. Given new molecular genetic approaches, further study of genetic variants and their association with manifestations of pulmonary stenosis opens up prospects for screening and individualized treatment of such patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The development of pulmonary supravalvular stenosis can be influenced by various risk factors, both physical and chemical. The main risk factors include:<\/p>\n<ul>\n<li>Heredity - the presence of cases of pulmonary stenosis in the family.<\/li>\n<li>Environmental factors \u2013 exposure to toxins during pregnancy, such as smoking, alcohol and drug use.<\/li>\n<li>Infections - Certain maternal infections during pregnancy, such as rubella, can lead to the development of congenital heart defects.<\/li>\n<li>Pharmaceutical drugs taken by the mother during pregnancy, such as some antidepressants and acne medications.<\/li>\n<li>Comorbid conditions of the mother, which include diabetes and obesity.<\/li>\n<\/ul>\n<p>When characterizing risk factors, it is necessary to take into account that the interaction of genetic and exogenous factors can significantly increase the likelihood of developing pulmonary supravalvular stenosis, which requires an individualized approach to monitoring and prevention in this group of patients.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of pulmonary supravalvular stenosis is based on a comprehensive approach, including an assessment of clinical symptoms and the results of various research methods. The main symptoms of the disease may include:<\/p>\n<ul>\n<li>Shortness of breath during physical exertion.<\/li>\n<li>Fatigue and weakness.<\/li>\n<li>Chest pain, which may be episodic.<\/li>\n<li>Fainting and pre-fainting conditions.<\/li>\n<li>Enlargement of the right ventricle on echocardiogram.<\/li>\n<\/ul>\n<p>Laboratory tests, such as blood tests for natriuretic peptide levels, can help in the evaluation of heart failure. Radiologic examinations, including chest radiography and echocardiography, are the main methods of imaging the heart and detecting structural abnormalities. Doppler ultrasound is important for assessing the supravalvular pressure gradient and myocardial thickness. When necessary, more modern approaches, such as magnetic resonance imaging (MRI), are used to analyze the cardiac anatomy in detail. The differential diagnosis, which may include aortic stenosis and other defects that cause similar clinical manifestations, should also be considered in the diagnostic process.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of pulmonary supravalvular stenosis depends on the severity of the disease and most often includes both conservative and surgical methods. The general treatment strategy is aimed at eliminating or reducing the pressure gradient in the supravalvular outlet area, which helps relieve symptoms.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<p>Pharmacological treatment is usually aimed at managing symptoms and preventing heart failure. Diuretics are used to control swelling and beta blockers are used to reduce heart rate and improve cardiac function.<\/p>\n<p>Surgical treatment is recommended in the presence of severe symptoms and severe stenosis. The most common method is balloon dilation of the pulmonary valve, which is a minimally invasive procedure. If this method is ineffective, open surgery with valve replacement or plastic surgery may be used.<\/p>\n<p>Other treatments may include the use of stenting, particularly in patients with recurrent stenosis after balloon dilation, as well as rehabilitation and lifestyle support aimed at optimizing physical activity and cardiovascular health.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat pulmonary supravalvular stenosis include:<\/p>\n<ul>\n<li>Diuretics (eg, furosemide, spironolactone).<\/li>\n<li>Beta blockers (eg, carvedilol, metoprolol).<\/li>\n<li>Antiplatelet drugs (eg, aspirin) to reduce the risk of blood clots.<\/li>\n<li>ACE inhibitors (eg, captopril) to improve cardiovascular function.<\/li>\n<\/ul>\n<p>The combination of these drugs allows for successful control of symptoms and improvement of quality of life in patients with pulmonary supravalvular stenosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with pulmonary supravalvular stenosis is an essential part of managing the condition. Necessary monitoring steps include regular cardiology examinations, echocardiographic examination, and blood tests to assess levels of natriuretic peptides and other markers of cardiac function.<\/p>\n<p>The prognosis depends on the severity of the stenosis and the presence of concomitant diseases. In cases of mild disease, patients can lead a normal life, while others have a high probability of progression of the condition and the need for surgical intervention. Complications may include arrhythmia, blood clots, and the development of heart failure, which requires special attention and timely correction in therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pulmonary supravalvular stenosis may present differently in different age groups. In newborns, the condition is often detected during screening examinations, and in most cases the process progresses slowly. In children and adolescents, the clinical picture can be varied, sometimes appearing only during physical activity. In adult patients, the stenosis often leads to more pronounced symptoms related to physical activity and requires a more aggressive approach to treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is pulmonary supravalvular stenosis?<\/strong> This is a narrowing of the outflow tract of the right ventricle of the heart, which prevents normal blood circulation to the lungs.<\/li>\n<li><strong>What are the main symptoms of pulmonary stenosis?<\/strong> Shortness of breath, fatigue, chest pain and fainting.<\/li>\n<li><strong>How is pulmonary supravalvular stenosis diagnosed?<\/strong> Using echocardiography, radiography and other imaging methods.<\/li>\n<li><strong>What is the treatment for this disease?<\/strong> Treatment includes drug therapy, surgery and extensive monitoring of the patient&#039;s condition.<\/li>\n<li><strong>What is the prognosis for pulmonary supravalvular stenosis?<\/strong> The prognosis depends on the severity of the disease; many patients lead normal lives, but severe cases may require surgery.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Pulmonary supravalvular stenosis (PSVS) is a narrowing of the right ventricular outflow tract of the heart that interferes with normal blood flow from the heart to the lungs.<\/p>","protected":false},"author":1,"featured_media":21563,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12471","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12471"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12471\/revisions"}],"predecessor-version":[{"id":14608,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12471\/revisions\/14608"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21563"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12471"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}