{"id":12468,"date":"2024-10-11T21:01:04","date_gmt":"2024-10-11T19:01:04","guid":{"rendered":"https:\/\/valintermed.com\/?p=12468"},"modified":"2024-10-11T21:01:04","modified_gmt":"2024-10-11T19:01:04","slug":"legochnaya-gipertenziya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/","title":{"rendered":"Pulmonary hypertension"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Pulmonary hypertension (PH) is a pathological condition characterized by increased pressure in the pulmonary artery, which subsequently leads to deterioration of the blood supply to the lungs and a decrease in cardiac function. As a result, shortness of breath, fatigue, and heart failure may develop. This disease is diverse in its pathogenesis and can be both primary and secondary. Primary pulmonary hypertension is a rare disease, while secondary hypertension can be a consequence of various diseases of the lungs, cardiovascular system, or systemic diseases. It is important to note that the course of pulmonary hypertension can be progressive, and its results depend on timely diagnosis and high-quality treatment.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-hypertension\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pulmonary hypertension has a long and complex history. The first mentions of this condition date back to the 19th century. In 1891, German pathologist Friedrich Oskar Hirsch described cases in which high pulmonary pressure was observed. In the 1970s, thanks to research aimed at studying the mechanisms of this pathology, active development of diagnostics and treatment of pulmonary hypertension began. In 1973, the first clinical trials of drugs such as glucagon receptor antagonists were presented, opening up new horizons for the treatment of the disease. Interestingly, in 2013, the world&#039;s first successful lung transplant was performed on a person with pulmonary hypertension, demonstrating the importance of surgical intervention in advanced forms of the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The epidemiology of pulmonary hypertension is an important aspect of understanding this disease. According to expert estimates, the incidence of pulmonary hypertension ranges from 15 to 50 cases per million population, depending on the type of disease and region. It has been established that primary pulmonary hypertension is much less common than secondary, and has a prevalence of about 5-10 cases per million. According to studies, the incidence among women is 2-4 times higher than among men. In addition, pulmonary hypertension is more often diagnosed in people aged 30 to 50 years, but there are cases in a younger age category. Secondary pulmonary hypertension, in turn, is much more common, and its occurrence is associated with diseases such as chronic obstructive pulmonary disease, heart failure and other cardiorespiratory pathologies.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Research suggests that pulmonary hypertension may be associated with a genetic predisposition. In particular, the hereditary form of the disease (hereditary variant of primary pulmonary hypertension) is often associated with mutations in genes encoding proteins involved in vascular tone and pulmonary vascular remodeling. The most frequently mentioned genes are:<\/p>\n<ul>\n<li>BMPR2 (bone growth factor receptor type II)<\/li>\n<li>ALK1 (angiogenic protein product)<\/li>\n<li>ENG (endoglin)<\/li>\n<li>SMAD9 (signal transduction promoter)<\/li>\n<\/ul>\n<p>Mutations in these genes can lead to abnormal vascular remodeling and increased pulmonary arterial pressure. In addition to hereditary factors, environmental influences are also important, including a combination of genetic and environmental factors, making pulmonary hypertension a complex disease with multiple risk factors. Extensive research continues to identify other potential genes and mechanisms that may contribute to the condition.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are a number of risk factors that can contribute to the development of pulmonary hypertension. They can be divided into physical and chemical. Physical risk factors include:<\/p>\n<ul>\n<li>Lung diseases such as chronic obstructive pulmonary disease and interstitial lung diseases.<\/li>\n<li>Heart disease, including congenital heart defects and chronic heart failure.<\/li>\n<li>Obstructive conditions such as sleep apnea.<\/li>\n<\/ul>\n<p>Chemical risk factors include:<\/p>\n<ul>\n<li>Drug use (eg, amphetamines).<\/li>\n<li>Exposure to toxic substances (eg, overexposure to carbon monoxide).<\/li>\n<li>Infectious diseases such as HIV, which can lead to pulmonary hypertension.<\/li>\n<\/ul>\n<p>In addition, it is worth noting other possible related factors, such as:<\/p>\n<ul>\n<li>Smoking and bad habits.<\/li>\n<li>Obesity, which leads to increased stress on the cardiovascular system.<\/li>\n<li>Physical inactivity, which also leads to deterioration of the condition of blood vessels and increases the risk of hypertension.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of pulmonary hypertension is a multi-stage process that includes analysis of the clinical picture, laboratory and instrumental studies. The main symptoms of the disease are often non-specific, but among them we can highlight:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Shortness of breath during physical activity and at rest.<\/li>\n<li>Fatigue and general weakness.<\/li>\n<li>Chest pain.<\/li>\n<li>Swelling in the legs and abdomen, which may indicate right ventricular failure.<\/li>\n<\/ul>\n<p>Laboratory tests may include:<\/p>\n<ul>\n<li>A complete blood count (CBC), which can help detect anemia.<\/li>\n<li>Biochemical tests to assess liver and kidney function and electrolyte balance.<\/li>\n<li>Tests for infectious diseases, demographic disorders and other conditions.<\/li>\n<\/ul>\n<p>Radiological examinations include:<\/p>\n<ul>\n<li>A chest x-ray to assess the size of the heart and the condition of the lungs.<\/li>\n<li>Computed tomography (CT) for a more detailed study of the condition of the pulmonary vessels.<\/li>\n<li>Magnetic resonance imaging (MRI) to assess heart function.<\/li>\n<\/ul>\n<p>The primary method for diagnosing pulmonary hypertension is pulmonary artery catheterization, which allows direct measurement of pulmonary artery pressure and the exclusion of other conditions that cause similar symptoms. It is also important to conduct a differential diagnosis with other diseases, such as heart failure, obstructive pulmonary disease, and various cardiomyopathies.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of pulmonary hypertension should be individualized and comprehensive. Depending on the cause and severity of the condition, the prescriptions may vary. The main treatment areas include:<\/p>\n<ul>\n<li>Pharmacological treatment aimed at reducing pulmonary arterial pressure.<\/li>\n<li>Surgical intervention in cases where drug therapy may be ineffective.<\/li>\n<li>Oxygen therapy to improve tissue oxygenation.<\/li>\n<li>Rehabilitation and lifestyle changes to increase physical activity and improve the patient&#039;s overall condition.<\/li>\n<\/ul>\n<p>Pharmacological treatment includes the prescription of such groups of drugs as:<\/p>\n<ul>\n<li>Prostaglandins, such as iloprost and beriloproxt.<\/li>\n<li>Endothelial antagonists such as bosentan and ambrisentan.<\/li>\n<li>Phosphodiesterase inhibitors, such as sildenafil and tadalafil.<\/li>\n<\/ul>\n<p>Surgical treatment may include lung transplantation or shunt creation, as well as interventional procedures to reduce pressure in the pulmonary artery.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The following main classes of drugs are used for pulmonary hypertension:<\/p>\n<ul>\n<li>Endothelin receptor antagonists (bosentan, ambrisentan).<\/li>\n<li>Phosphodiesterase inhibitors (sidadenafil, tadalafil).<\/li>\n<li>Prostaglandins (iloprost, beropost).<\/li>\n<li>A class of drugs that increase the synthesis of nitric oxide (adenosine).<\/li>\n<\/ul>\n<p>Each of these medications has its own indications and contraindications, and the choice of a specific drug depends on the clinical situation and concomitant diseases.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring pulmonary hypertension plays a key role in disease management. Regular examinations and monitoring of the patient&#039;s condition are of great importance to assess the effectiveness of treatment and identify possible complications. Control stages include:<\/p>\n<ul>\n<li>Periodic blood pressure measurements.<\/li>\n<li>Laboratory tests to assess organ function.<\/li>\n<li>Instrumental examinations such as echocardiography and CT.<\/li>\n<\/ul>\n<p>The prognosis for pulmonary hypertension depends on its type, cause, and severity. Early diagnosis and adequate treatment can significantly improve patients&#039; quality of life and prolong life. However, if left untreated, pulmonary hypertension can lead to serious complications, including right ventricular failure and arrhythmia.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Pulmonary hypertension may have different clinical manifestations depending on the patient&#039;s age. In children and adolescents, it is often secondary and associated with congenital heart defects, which requires a special approach to diagnosis and treatment. In adults, the disease is often idiopathic or associated with concomitant diseases. In elderly patients, pulmonary hypertension may be combined with other age-related pathologies, which complicates diagnosis and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is pulmonary hypertension?<\/strong> Pulmonary hypertension is a condition characterized by increased pressure in the pulmonary artery, which can lead to right heart failure and poor blood oxygenation.<\/li>\n<li><strong>What are the symptoms of pulmonary hypertension?<\/strong> The main symptoms include shortness of breath, fatigue, chest pain, swelling in the legs and abdomen.<\/li>\n<li><strong>How is pulmonary hypertension diagnosed?<\/strong> Diagnosis includes a clinical examination, laboratory tests, radiological examinations, and pulmonary artery catheterization to measure pressure.<\/li>\n<li><strong>What treatment methods are used?<\/strong> Treatment may include drug therapy, oxygen therapy, and surgical procedures such as lung transplantation.<\/li>\n<li><strong>What is the prognosis for patients with pulmonary hypertension?<\/strong> The prognosis depends on the type of disease, the severity of the condition and the response to treatment; with early diagnosis and adequate treatment, the prognosis can be significantly improved.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Pulmonary hypertension (PH) is a pathological condition characterized by an increase in pressure in the pulmonary artery, which subsequently leads to a deterioration in the blood supply to the lungs<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12468","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12468"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12468\/revisions"}],"predecessor-version":[{"id":14611,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12468\/revisions\/14611"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}