{"id":12453,"date":"2024-10-11T21:17:34","date_gmt":"2024-10-11T19:17:34","guid":{"rendered":"https:\/\/valintermed.com\/?p=12453"},"modified":"2024-10-11T21:17:34","modified_gmt":"2024-10-11T19:17:34","slug":"defitsit-fosfoglitseratkinazy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/phosphoglycerate-kinase-deficiency\/","title":{"rendered":"Phosphoglycerate kinase deficiency"},"content":{"rendered":"
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Phosphoglycerate kinase deficiency (PGK) is a rare inherited disorder characterized by a deficiency of the enzyme phosphoglycerate kinase, which is involved in carbohydrate metabolism, namely glycolysis. This enzyme plays a key role in providing cells with energy, as it catalyzes the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, which is an important step in the breakdown of glucose. Deficiency of this enzyme can lead to various metabolic disorders, lack of energy in cells and, as a result, to various clinical manifestations, including muscle weakness and disorders of other body systems.<\/p>\n

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