{"id":12445,"date":"2024-10-11T21:31:49","date_gmt":"2024-10-11T19:31:49","guid":{"rendered":"https:\/\/valintermed.com\/?p=12445"},"modified":"2024-10-11T21:31:49","modified_gmt":"2024-10-11T19:31:49","slug":"defitsit-prekallikreina","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/precalcitrant-deficiency\/","title":{"rendered":"Prekallikrein deficiency"},"content":{"rendered":"
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Prekallikrein deficiency is a rare hereditary disorder caused by a deficiency of prekallikrein, a precursor of active kallikrein that is involved in the cascade activation of a system of cofactors that play a key role in hemostasis and regulation of inflammatory systems. Prekallikrein, performing its function in the body, promotes the formation of bradykinin, which in turn affects vascular permeability, blood pressure, and pain sensitivity. Possible manifestations of this deficiency may include an increased risk of thrombosis, cardiovascular dysfunction, and various symptoms of blood system dysfunction.<\/p>\n

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