{"id":12430,"date":"2024-10-11T21:41:48","date_gmt":"2024-10-11T19:41:48","guid":{"rendered":"https:\/\/valintermed.com\/?p=12430"},"modified":"2024-10-11T21:41:48","modified_gmt":"2024-10-11T19:41:48","slug":"vrozhdennaya-pahionihiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/congenital-pain\/","title":{"rendered":"Congenital pachyonychia"},"content":{"rendered":"
<\/div>\n

Pachyonychia congenita is a rare genetic disorder characterized by thickening and altered nail structure and hyperkeratosis of the skin. The condition is hereditary and is associated with abnormalities in the formation of the horny layer. Pachyonychia affects not only the nails but also the skin and may be accompanied by other diseases such as skin dystrophy, onycholysis and various skin infections. Symptoms of the disease can range from mild to severe, and the severity of manifestations can vary significantly among patients. The general pathophysiology of this disorder involves defects in keratinocytes, which leads to a disruption of the normal keratinization process.<\/p>\n

\n
\n

Content<\/p>\nToggle<\/span><\/path><\/svg><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n