{"id":12414,"date":"2024-10-11T21:58:15","date_gmt":"2024-10-11T19:58:15","guid":{"rendered":"https:\/\/valintermed.com\/?p=12414"},"modified":"2024-10-11T21:58:15","modified_gmt":"2024-10-11T19:58:15","slug":"atreziya-legochnoy-arterii-s-intaktnoy-mezhzheludochkovoy-peregorodkoy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/","title":{"rendered":"Pulmonary atresia with intact interventricular septum"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Pulmonary atresia with intact interventricular septum (PAI with IVI) is a rare but serious congenital cardiovascular disease characterized by complete or partial obstruction of the pulmonary artery while maintaining the normal structure of the interventricular septum. This pathology leads to insufficient blood supply to the lungs, which causes oxygen starvation of the body and can cause serious complications such as pulmonary hypertension, heart failure and even death. PAI with IVI is often the result of abnormal development of embryonic structures during fetal development, which makes treatment of this disease extremely important for preserving the life and health of the patient.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of drugs used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/pulmonary-artery-resection-with-intact-interventricular-partition\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The history of detection and diagnosis of pulmonary atresia is closely related to the development of cardiac surgery and medical imaging. The first descriptions of such anomalies were documented in the late 19th and early 20th centuries. However, systematic study and classification of pulmonary anomalies began only with the development of echocardiography and angiocardiography in the 1970s. Cases of pulmonary atresia with an intact interventricular septum structure have been actively studied since the early 1980s, when significant efforts were devoted to the development of cardiac surgery. It is interesting to note that in the early 2000s, as a result of improved diagnostics and treatment methods, the survival rate of newborns with this pathology increased significantly, allowing many patients to live to adulthood and lead a full life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to modern epidemiological studies, pulmonary atresia with an intact interventricular septum occurs with a frequency of approximately 1-3 cases per 10,000 live births. Considering that this disease is one of the rare heart defects, its prevalence in the population is quite low. It is noteworthy that among all congenital cardiovascular defects, APA with UTI accounts for about 2-5% cases. Studying the epidemiological features of such conditions allows us to identify general patterns associated with cultural and environmental conditions, which in turn can help in developing prevention methods.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Genetic predisposition to pulmonary atresia is debated among researchers, as certain chromosomal abnormalities and mutations may increase the risk of developing this pathology. In particular, changes have been identified in genes associated with the development of the cardiovascular system, such as the NOTCH1, NKX2-5, and GATA4 genes. These mutations may not only predispose to arterial atresia, but also be accompanied by other developmental defects. For example, in children with Down syndrome or Turner syndrome, the risk of developing this anomaly also increases significantly. There is an opinion that among families where one of the children is diagnosed with heart defects, the likelihood of similar anomalies in subsequent children is higher.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors that contribute to the development of pulmonary atresia with an intact interventricular septum include the following:<\/p>\n<ul>\n<li>Genetic abnormalities and hereditary predisposition.<\/li>\n<li>Maternal age - women over 35 years of age have an increased risk of giving birth to children with congenital anomalies.<\/li>\n<li>Harmful habits of the mother, such as smoking and alcohol abuse during pregnancy.<\/li>\n<li>Infectious diseases during pregnancy, such as rubella, cytomegalovirus infection or toxoplasmosis.<\/li>\n<li>Environmental factors, including exposure to toxic substances and chemicals.<\/li>\n<\/ul>\n<p>Understanding these factors makes it possible to improve prenatal screening and take steps to reduce the likelihood of developing this disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of pulmonary atresia with an intact interventricular septum involves several important steps. The patient&#039;s main symptoms may include:<\/p>\n<ul>\n<li>Cyanosis is a bluish discoloration of the skin and mucous membranes.<\/li>\n<li>Shortness of breath and difficulty breathing.<\/li>\n<li>Inability to achieve satisfactory oxygenation.<\/li>\n<li>Fatigue and limited physical activity.<\/li>\n<\/ul>\n<p>Laboratory tests may include a complete blood count, blood gas analysis, and oxygen index. Radiologic tests such as a chest x-ray may reveal enlargement of the right heart and pulmonary trunk. Echocardiography is the gold standard for diagnosis and evaluation of cardiac anatomy, allowing visualization of pulmonary artery abnormalities. In some cases, angiography may be performed to clarify the vascular structure. Differential diagnoses include conditions such as coarctation of the aorta and other types of congenital heart disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of pulmonary atresia with an intact ventricular septum involves a comprehensive approach aimed at relieving the obstruction and improving hemodynamics. General treatments may include neonatal resuscitation and oxygenation techniques. Pharmacological treatment may be aimed at maintaining adequate oxygen levels and improving cardiac function, including vasodilators to reduce pulmonary hypertension. Surgical treatment is usually performed early in life and may include shunt procedures or a complete reconstructive surgical approach. In other cases, balloon angioplasty or stenting may be used to widen the pulmonary artery. However, the effectiveness of these methods depends on the individual patient and the abnormalities in the cardiac structure.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of drugs used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Prostaglandins (eg, Alprostadil) - help maintain the patency of the ductus arteriosus and increase blood flow to the lungs.<\/li>\n<li>Vasodilators (eg, Sildenafil) - used to reduce pulmonary hypertension.<\/li>\n<li>Diuretics - help manage swelling and cardiac strain.<\/li>\n<li>Beta blockers (eg, Metoprolol) - may be prescribed to control heart rhythm and reduce the workload on the heart.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with APA with an intact ventricular septum includes regular checks with a cardiologist, as well as periodic ECGs and echocardiograms. Monitoring steps typically include:<\/p>\n<ul>\n<li>Assessing the patient&#039;s physical condition and activity level.<\/li>\n<li>Monitoring blood oxygen levels.<\/li>\n<li>Measuring blood pressure and heart rate.<\/li>\n<\/ul>\n<p>The prognosis in case of successful surgical correction can be favorable, however there is a risk of developing complications such as pulmonary hypertension and heart failure, which require constant monitoring and additional interventions. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In newborns and young children, pulmonary atresia is more acute and will require immediate intervention after birth. In adulthood, patients may have milder symptoms, but the risk of developing pulmonary hypertension increases over time. In the elderly, the condition may worsen due to underlying medical conditions and age-related changes, requiring more careful diagnosis and monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is the main treatment for pulmonary atresia with an intact interventricular septum?<\/strong> The main treatment involves surgery to restore blood flow and reduce pulmonary hypertension.<\/li>\n<li><strong>What are the possible complications of this pathology?<\/strong> Possible complications include pulmonary hypertension, heart failure, and heart rhythm disturbances.<\/li>\n<li><strong>How is this disease diagnosed?<\/strong> Diagnosis includes echocardiography, radiography and sometimes angiography.<\/li>\n<li><strong>What is the survival rate of ALA patients with UTI after surgery?<\/strong> In the modern period, patient survival has increased significantly and reaches 85-90% depending on the severity of the disease.<\/li>\n<li><strong>Can the disease manifest itself in adulthood?<\/strong> APA with an intact interventricular septum is often diagnosed in childhood, but symptoms may appear or worsen in adulthood due to changes in the pulmonary vasculature.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Pulmonary artery atresia with intact interventricular septum (PAA with IVI) is a rare but serious congenital cardiovascular disorder characterized by complete<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12414","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12414","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12414"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12414\/revisions"}],"predecessor-version":[{"id":14665,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12414\/revisions\/14665"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12414"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12414"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12414"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}