{"id":12368,"date":"2024-10-11T22:39:35","date_gmt":"2024-10-11T20:39:35","guid":{"rendered":"https:\/\/valintermed.com\/?p=12368"},"modified":"2024-10-11T22:39:35","modified_gmt":"2024-10-11T20:39:35","slug":"otospondilomegaepifizarnaya-displaziya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/otospondylomegaepiphizarnaya-displaziya\/","title":{"rendered":"Otospondylomegaepiphyseal dysplasia"},"content":{"rendered":"
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Otospondylomegaepiphyseal dysplasia (OMIM 186850) is a rare genetic disorder that belongs to the group of disproportionate forms of dwarfism, characterized by abnormalities in the formation and development of cartilage and bones. The main clinical manifestations include shortening of the limbs, severe shortening of the pelvis and femurs, growth abnormalities and spinal deformities, as well as possible abnormalities in joint function. The disease may also be accompanied by scoliosis, chest abnormalities, and excess adipose tissue. Otospondylomegaepiphyseal dysplasia is caused by genetic mutations that affect the development of the musculoskeletal system and the metabolism of cartilage tissue.<\/p>\n

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