{"id":12344,"date":"2024-10-11T23:12:27","date_gmt":"2024-10-11T21:12:27","guid":{"rendered":"https:\/\/valintermed.com\/?p=12344"},"modified":"2024-10-11T23:12:27","modified_gmt":"2024-10-11T21:12:27","slug":"orofatsiodigitalnyy-sindrom-4","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-4\/","title":{"rendered":"Orofaciodigital syndrome 4"},"content":{"rendered":"
<\/div>\n

Orofaciodigital syndrome 4 (OFDS 4) is a genetic disorder characterized by a multifactorial developmental disorder that affects the structure of the face, oral cavity, and extremities. The main clinical manifestations of the syndrome include abnormalities in the arrangement and shape of teeth, defects in tooth enamel, a lack or excess of fingers and toes, and various abnormalities of facial symmetry. The disease is caused by mutations in certain genes, which leads to disruption of normal embryonic development. Particular attention has recently been paid to identifying polymorphisms of developing genes that can manifest in clinical practice in the form of various phenotypes of the disease.<\/p>\n

\n
\n

Content<\/p>\nToggle<\/span><\/path><\/svg><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n