{"id":12342,"date":"2024-10-11T23:13:25","date_gmt":"2024-10-11T21:13:25","guid":{"rendered":"https:\/\/valintermed.com\/?p=12342"},"modified":"2024-10-11T23:13:25","modified_gmt":"2024-10-11T21:13:25","slug":"orofatsiodigitalnyy-sindrom-1","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/","title":{"rendered":"Orofaciodigital syndrome 1"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Orofaciodigital syndrome 1 (OFDS-1) is a rare genetic disorder that belongs to a group of congenital anomalies. It is characterized by specific changes in the face and mouth, as well as anomalies of the hands and fingers. Clinical manifestations include microcephaly, underdevelopment or absence of the upper lip (under the cleft lip), coarse facial features, dental anomalies, and radiomorphological changes in the bones of the skull. It is important to note that this syndrome is familial and its clinical manifestations may vary depending on individual predisposition, which complicates diagnosis and requires a comprehensive approach to examination.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/orofatsia-digitalis-syndrome-1\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Orofaciodigital syndrome was first described in 1975 in the works of researchers examining anomalies in the development of the craniofacial region. Since then, a lot of data has been accumulated confirming the connection of this syndrome with various genetic mutations. It is important to note that the first mentions of similar anomalies can be found in ancient times, when, based on visual observations, assumptions could arise about the hereditary nature of some pathologies. In 1996, the gene responsible for this syndrome, HNF1B, was isolated, which opened up new horizons in the field of molecular genetics.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The prevalence of orofaciodigital syndrome 1 is quite low, approximately 1 in 100,000 live births. However, it should be noted that some cases may remain unreported due to asymptomatic progression and insufficient awareness of health workers about the signs of this syndrome. According to a study conducted in 2010 in Europe, it was found that the syndrome was recorded predominantly in women, which is associated with chromosomal abnormalities that lead to this condition. Genetic studies show that parents with such anomalies in their family tree have a higher risk of passing these mutations on to their children.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Mutations in the genes responsible for the development of orofaciodigital syndrome 1 relate to a group of cells responsible for fetal development. The most common problematic gene is HNF1B, located on chromosome 17. Various mutations in the sequences of this gene are known, leading to a change in its function. Studies show that about 60% patients with OFDS-1 carry mutations in this gene. The most common groups of genetic changes include deletions, duplications, and other structural variations. It is important to consider that the syndrome is inherited in an autosomal dominant manner, which makes its predisposition more pronounced in cases where one of the parents has the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Among the risk factors for the development of orofaciodigital syndrome 1, both genetic and exogenous factors are distinguished. The most significant include:<\/p>\n<ul>\n<li>Heredity - the presence of similar cases in the family significantly increases the likelihood of having a child with this syndrome.<\/li>\n<li>Age of parents - mothers over 35 years of age have an increased risk of fetal abnormalities.<\/li>\n<li>Environmental factors - exposure to toxic substances in the environment, such as heavy metals, can have a negative impact on fetal development.<\/li>\n<li>Viral infections in early pregnancy - infections such as rubella or cytomegalovirus can lead to developmental problems in the fetus.<\/li>\n<\/ul>\n<p>Thus, the factors leading to OFDS-1 are varied and require careful analysis to determine the likelihood of developing the disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnosis of orofaciodigital syndrome 1 includes several stages. At the initial stage, attention is paid to the presence of characteristic clinical symptoms, such as:<\/p>\n<ul>\n<li>Facial anomalies: absence of upper lip, microcephaly, imperfect dental development.<\/li>\n<li>Any anomalies in the structure of the fingers: the presence of extra or missing fingers.<\/li>\n<li>Associated pathological conditions: hearing or vision impairment.<\/li>\n<\/ul>\n<p>Laboratory tests necessarily include analysis of genetic material to identify mutations in the genes responsible for the syndrome. Radiological examinations, such as bone X-rays, help to identify structural changes in the skull and limbs. Ultrasound may be useful in prenatal screening to detect abnormalities in the fetus. Differential diagnosis should also include other genetic syndromes, such as Apert syndrome or Brown syndrome, as they may present with similar characteristics.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of orofaciodigital syndrome 1 requires a comprehensive approach, which should include both conservative and surgical methods. Depending on the clinical picture, the main focus is on:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Pharmacological treatment - medications are used to correct symptoms, such as analgesics to reduce pain.<\/li>\n<li>Surgical intervention - in cases of severe anomalies, operations to correct facial anomalies or form fingers may be necessary.<\/li>\n<li>Other treatments include physical therapy and rehabilitation programs aimed at improving the functionality of the limbs and organs.<\/li>\n<\/ul>\n<p>Effective treatment requires a multidisciplinary approach involving geneticists, surgeons, orthopedists and rehabilitation specialists.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The list of drugs used to treat orofaciodigital syndrome 1 may vary depending on the clinical manifestations. The main groups of drugs include:<\/p>\n<ul>\n<li>Painkillers - such as paracetamol or ibuprofen to reduce pain.<\/li>\n<li>Drugs to correct concomitant disorders, such as antipsychotics in the presence of behavioral disorders.<\/li>\n<li>Preparations that improve microcirculation and support the immune system.<\/li>\n<\/ul>\n<p>Drug therapy is selected individually for each patient and may require adjustments during the treatment process.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Patients with orofaciodigital syndrome 1 should be monitored as part of regular follow-up. Monitoring steps include:<\/p>\n<ul>\n<li>A routine examination using modern imaging techniques to assess the condition of bones and tissues.<\/li>\n<li>Genetic testing to detect new mutations and assess risks in future children.<\/li>\n<li>Psychological support and assistance in rehabilitation.<\/li>\n<\/ul>\n<p>The prognosis for OFDS-1 can range from good to serious, depending on the severity of the abnormalities. Complications may be associated with functional impairment and require additional medical interventions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The course of orofaciodigital syndrome varies depending on the age group of patients. Newborns have the most pronounced clinical symptoms, while as they grow older, patients may face complications related to social adaptation and psychoemotional state. In older age, additional anomalies may be observed that require surgical intervention. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of orofaciodigital syndrome 1?<\/strong> The main symptoms include facial abnormalities, underdeveloped or missing teeth, and abnormalities of the fingers and hands.<\/li>\n<li><strong>Can this disease be prevented?<\/strong> There is no complete prevention of OFDS-1, but minimizing exposure to exogenous factors and early diagnosis can help manage the condition.<\/li>\n<li><strong>What diagnostic methods are used to confirm OFDS-1?<\/strong> Diagnostic methods include genetic testing, X-ray examinations and ultrasound examination during pregnancy.<\/li>\n<li><strong>What are the treatments for OFDS-1?<\/strong> Treatment may include medication, surgery, and rehabilitation programs.<\/li>\n<li><strong>What is the prognosis for children with orofaciodigital syndrome 1?<\/strong> The prognosis depends on the severity of symptoms and the quality of medical care provided to patients. The right approach can significantly improve quality of life.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Orofaciodigital syndrome 1 (OFDS-1) is a rare genetic disorder that belongs to a group of congenital anomalies. It is characterized by specific changes in the facial area.<\/p>","protected":false},"author":1,"featured_media":21337,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12342","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12342"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12342\/revisions"}],"predecessor-version":[{"id":14737,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12342\/revisions\/14737"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21337"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12342"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12342"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}