{"id":12291,"date":"2024-10-11T23:58:25","date_gmt":"2024-10-11T21:58:25","guid":{"rendered":"https:\/\/valintermed.com\/?p=12291"},"modified":"2024-10-11T23:58:25","modified_gmt":"2024-10-11T21:58:25","slug":"uzlovaya-limfoma-hodzhkina-s-preobladaniem-limfotsitov-nlphl","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/","title":{"rendered":"Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL)"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Nodal lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma, which is a malignancy characterized by isolated enlargement of lymph nodes with a predominance of lymphocytes. This disease has unique morphologic and clinical features that distinguish it from other forms of lymphoma. In NLPHL, there is the presence of specific cells - classical Hodgkin cells, but in much smaller quantities compared to other subtypes. Clinically, it often manifests as asymptomatic enlargement of lymph nodes, mainly in the neck and clavicle area. The disease is characterized by a favorable prognosis and low aggressiveness, but requires accurate diagnosis and adequate therapy.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hodgkin-s-lymphoma-with-lymph-node-predominance-nlphl\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nodular Hodgkin lymphoma was first described in 1983, when it was identified as a distinct subtype of Hodgkin lymphoma. The name &quot;lymphocyte-predominant lymphoma&quot; was chosen to emphasize the characteristic cells and their predominance in biopsy specimens. The first mentions of lymphomas date back to the works of such eminent scientists as T. Hodgkin, who described classical Hodgkin lymphoma in 1832. Subsequently, despite significant advances in understanding the pathogenesis and clinical manifestations, NLPHL remained poorly understood until the early 21st century. The advent of new molecular diagnostics and genetic research has provided a deeper understanding of the mechanisms of this disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The epidemiology of nodular lymphocyte-predominant Hodgkin lymphoma shows that this disease is quite rare compared to other lymphoma subtypes. According to recent studies, the incidence statistics are about 0.5 cases per 100,000 people per year. The average age of patients is usually between 20 and 30 years, and there is an increased incidence in men. It is noteworthy that war or other social stress may increase the incidence rate, but this will require further research to confirm such a correlation. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>It is now established that genetic predisposition plays an important role in the development of nodular lymphocyte-predominant Hodgkin lymphoma. The study of mutations in genes such as BCL2, BCL6, and MYC, as well as abnormalities in genes responsible for the immune response, indicate the likelihood of an inherited factor. In particular, studies show that among patients with a family history of lymphoproliferative diseases, the risk of the disease is significantly higher. There is also a link between NPHL and syndromes associated with immunodeficiency, such as HIV infection and inherited immune disorders.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are several risk factors that may contribute to the development of nodular lymphocyte-predominant Hodgkin lymphoma. These include:<\/p>\n<ul>\n<li>The effects of radiation, particularly radiotherapy previously used to treat other tumors.<\/li>\n<li>Work in hazardous areas, including chemical industries and pesticide use.<\/li>\n<li>Lifetime exposure to chemicals such as benzene.<\/li>\n<li>Viral infections, especially HIV, Epstein-Barr virus and other viruses that affect the immune system.<\/li>\n<li>Hereditary factors and the presence of immune diseases in close relatives.<\/li>\n<\/ul>\n<p>These factors highlight the importance of preventive measures and the need to raise awareness of the risks associated with this disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of nodular lymphocyte-predominant Hodgkin lymphoma involves several key steps:<\/p>\n<ul>\n<li>General symptoms may include painless swollen lymph nodes, night sweats, weight loss, and general weakness.<\/li>\n<li>Laboratory tests may include a complete blood count, which most often shows anemia or changes in white blood cells.<\/li>\n<li>Radiological studies such as CT or MRI are necessary to detect lymph node involvement and to determine the stage of the disease.<\/li>\n<li>A lymph node biopsy confirms the diagnosis and allows for the assessment of the morphological characteristics of the tumor.<\/li>\n<li>Differential diagnosis is important to exclude other lymphoproliferative disorders such as non-Hodgkin&#039;s lymphomas and reactive processes in the lymph nodes.<\/li>\n<\/ul>\n<p>Thus, a thorough examination is necessary for an accurate and timely diagnosis of NLPHL.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for nodular lymphocyte-predominant Hodgkin lymphoma may involve a variety of approaches:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>General treatment often begins with observation, especially in asymptomatic cases.<\/li>\n<li>Pharmacological treatment usually involves chemotherapy, which uses drugs such as Abvitred and Bleomycin.<\/li>\n<li>Surgical treatment can be used in localized cases to resect the affected lymph node.<\/li>\n<li>In some cases, radiation therapy is used to achieve a complete response in cases of residual tumor mass.<\/li>\n<li>Immunotherapy, including the use of monoclonal antibodies, is also considered a promising approach in the treatment of this disease.<\/li>\n<\/ul>\n<p>The treatment plan is developed individually for each patient based on the stage of the disease and general health condition.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main groups of drugs used to treat nodular lymphocyte-predominant Hodgkin lymphoma are:<\/p>\n<ul>\n<li>Chemotherapeutic drugs: Doxorubicin, Dpogenflovadin, Bleomycin.<\/li>\n<li>Immunotherapeutic agents: Rituximab, Nacomer.<\/li>\n<li>Palliative drugs: Opioids, nonsteroidal anti-inflammatory drugs.<\/li>\n<\/ul>\n<p>The choice of specific drugs depends on many factors, including the stage of the disease and the patient&#039;s response to therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of the patient with lymphocyte-predominant nodular Hodgkin lymphoma includes regular clinical observation and follow-up studies. <\/p>\n<ul>\n<li>Control stages of treatment include regular check-ups with a doctor to assess the effectiveness of therapy and identify possible relapses.<\/li>\n<li>The prognosis for NLPHL is generally good, and many patients achieve long-term remission.<\/li>\n<li>Complications may include secondary tumors, complications from chemotherapy and radiation therapy, and organ dysfunction.<\/li>\n<\/ul>\n<p>The need for monitoring is due to the potential risk of relapse and long-term effects of treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nodular Hodgkin&#039;s lymphoma with lymphocyte predominance has age-related features of the course:<\/p>\n<ul>\n<li>In young people (aged 20-30 years), the disease often occurs with minimal symptoms and responds well to treatment.<\/li>\n<li>Elderly patients (over 60 years of age) experience more severe symptoms and are more likely to have concomitant diseases, which requires a more cautious approach to therapy.<\/li>\n<li>This disease is extremely rare in children, and its clinical manifestations and treatment require a special approach.<\/li>\n<\/ul>\n<p>These differences highlight the importance of a personalized approach to treatment based on age groups.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is nodular lymphocyte predominant Hodgkin lymphoma?<\/strong> This is a rare subtype of Hodgkin lymphoma characterized by lymphocyte predominance and a specific tumor cell morphology.<\/li>\n<li><strong>What are the main symptoms of the disease?<\/strong> The main symptoms include painless enlargement of the lymph nodes, general weakness, night sweats and weight loss.<\/li>\n<li><strong>How is lymphocyte-predominant nodular Hodgkin lymphoma diagnosed?<\/strong> Diagnosis includes biopsy, radiological examinations and laboratory tests.<\/li>\n<li><strong>What treatment is used for this disease?<\/strong> Treatment may include observation, chemotherapy, radiation therapy, and sometimes surgery.<\/li>\n<li><strong>What is the prognosis for patients with NLPHL?<\/strong> In most cases, the prognosis is favorable, especially with early detection and adequate treatment.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma that is a malignancy characterized by isolated enlargement of lymph nodes.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12291","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12291","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12291"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12291\/revisions"}],"predecessor-version":[{"id":14788,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12291\/revisions\/14788"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12291"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12291"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12291"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}