{"id":12282,"date":"2024-10-12T00:13:28","date_gmt":"2024-10-11T22:13:28","guid":{"rendered":"https:\/\/valintermed.com\/?p=12282"},"modified":"2024-10-12T00:13:28","modified_gmt":"2024-10-11T22:13:28","slug":"sindrom-nunan","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/","title":{"rendered":"Noonan syndrome"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Noonan syndrome is an inherited genetic disorder characterized by a variety of clinical features, including characteristic physiognomic features, short stature, heart defects, and other systemic abnormalities. The disorder results from genetic mutations, primarily in genes involved in cell signaling pathways involved in fetal development. The disorder has varying degrees of severity, illustrating its classic variability in presentation and prognosis. Patients may have a variety of comorbidities, complicating diagnosis and treatment. In addition, the syndrome often results in significant long-term consequences that impact patients&#039; quality of life.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nunan-syndrome\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Noonan syndrome was first described in 1968 by Dr. John Noonan, who conducted a clinical study collecting data on a group of patients with characteristic facial features and growth disorders. Over the past few decades, scientists have identified many genetic mutations associated with the syndrome, which has helped clarify the pathophysiology of this condition. The main studies in the field of the syndrome were conducted in the 1990s, when mutations in the KRAS, PTPN11 and SOS1 genes were identified. In 2002, molecular diagnostics were developed, which made it possible to verify the diagnosis based on genetic studies. Interestingly, Noonan syndrome is often included in the differential diagnosis of other diseases, such as Coffin-Smith syndrome and Benito syndrome.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Noonan syndrome has an incidence of approximately 1 in 1,000\u20132,500 births. However, due to the variability of presentation, its diagnosis can be difficult, leading to an underestimation of the true prevalence. Studies suggest that in populations with a high frequency of mismatches in genes, such as in descendants of migrants, the incidence of the syndrome may be as high as 1 in 1,000. The disorder is equally common among males and females, which may indicate an uncomplicated inheritance. Importantly, the recognition rate of the syndrome is increasing due to improved awareness of its clinical features and the availability of genetic testing.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Most cases of Noonan syndrome are associated with mutations in genes involved in cell survival and differentiation pathways. The most common mutations are in the following genes:<\/p>\n<ul>\n<li>PTPN11 - 50% cases;<\/li>\n<li>KRAS-15-20%;<\/li>\n<li>SOS1\u201410-15%;<\/li>\n<li>RAF1\u20145-10%;<\/li>\n<li>RIT1 \u2014 less than 5%;<\/li>\n<\/ul>\n<p>These mutations affect signaling pathways, leading to changes in growth and development. Inheritance may be either autosomal dominant or sporadic, where the mutation occurs for the first time in a patient with no family history. Knowing the genetic predisposition is important because it can help in early diagnosis and disease management.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors associated with Noonan syndrome include:<\/p>\n<ul>\n<li>Family history of Noonan syndrome or other genetic disorders;<\/li>\n<li>Age of parents (old age may increase the risk of mutations);<\/li>\n<li>Environmental factors (eg, maternal exposure to chemicals or radiation during pregnancy);<\/li>\n<li>Nutritional deficiencies in the mother during pregnancy;<\/li>\n<li>Infections suffered by the mother during pregnancy.<\/li>\n<\/ul>\n<p>It is important to note that the presence of the above factors does not guarantee the development of the syndrome, but may increase the chances of its occurrence. It should also be taken into account that the syndrome can manifest itself even in the absence of the listed factors.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of Noonan syndrome is based on clinical manifestations and confirmed by genetic testing. The main symptoms include:<\/p>\n<ul>\n<li>Characteristic facial features (wide forehead, low-set ears, open eyes, etc.);<\/li>\n<li>Lack of growth;<\/li>\n<li>Heart defects (eg, pulmonary artery stenosis);<\/li>\n<li>Disorders in the development of the genital organs;<\/li>\n<li>Some manifestations from the musculoskeletal system.<\/li>\n<\/ul>\n<p>Laboratory tests vary but may include a complete blood count and biochemical tests to evaluate the health of the heart, kidneys, and liver. Radiologic tests (ultrasound, MRI) may be used to look for structural abnormalities. It is also important to differentiate from other conditions, such as Warcherton syndrome and Down syndrome, to rule out overlapping symptoms.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of Noonan syndrome requires a multidisciplinary approach and is complex. The main areas include:<\/p>\n<ul>\n<li>General treatment: symptomatic therapy based on clinical manifestations;<\/li>\n<li>Pharmacological treatment: use of drugs to control cardiovascular disorders and other associated conditions;<\/li>\n<li>Surgical treatment: correction of heart defects and other anomalies;<\/li>\n<li>Other treatments include physical therapy and rehabilitation to improve functional capabilities.<\/li>\n<\/ul>\n<p>Treatment is individualized, taking into account the severity of the disease and the presence of comorbidities. A multidisciplinary team of doctors, including cardiologists, geneticists and internists, plays a key role in managing the syndrome.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The following medications may be used to treat concomitant manifestations of Noonan syndrome:<\/p>\n<ul>\n<li>Beta blockers (eg, atenolol) to control cardiovascular disorders;<\/li>\n<li>Anticoagulants for the prevention of thrombus formation;<\/li>\n<li>Growth hormone to increase growth in children with developmental delays;<\/li>\n<li>Medicines for the treatment of concomitant diseases (eg, diabetes or hypertension).<\/li>\n<\/ul>\n<p>It is also important to consider drug interactions and individual patient responses to treatment, which requires regular monitoring and adjustment of therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with Noonan syndrome involves regular monitoring, with emphasis on the cardiovascular, endocrine, and musculoskeletal systems. Prognosis is variable and depends on the severity of manifestations and organ involvement. Complications can be serious and include heart failure, recurrent infections due to immunocompromised state, and delayed psychoemotional development. Optimal monitoring and early intervention can significantly improve the outcome.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Noonan syndrome can manifest itself differently in different age groups. In newborns, it is important to pay attention to the presence of characteristic anatomical features and heart defects. In young children, retarded growth and delayed physical and sexual development are often observed. In adolescents, important social and emotional changes are observed, increasing problems with the perception of their own appearance and capabilities. In adult patients, chronic diseases may develop that require constant monitoring and treatment. Each age requires an individual approach and specialized methods of managing the condition.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of Noonan syndrome?<\/strong> The main symptoms are characteristic facial features, growth retardation, heart defects and abnormalities in the development of the genitals.<\/li>\n<li><strong>Can Noonan syndrome be prevented?<\/strong> There is currently no way to prevent Noonan syndrome, as it is primarily caused by genetic mutations.<\/li>\n<li><strong>How is Noonan syndrome diagnosed?<\/strong> Diagnosis is based on clinical manifestations and confirmed by genetic testing.<\/li>\n<li><strong>What treatment is indicated for Noonan syndrome?<\/strong> Treatment includes symptomatic therapy, pharmacological and surgical interventions if necessary.<\/li>\n<li><strong>What is the prognosis for Noonan syndrome?<\/strong> Prognosis varies depending on the severity of symptoms and the presence of comorbidities, but with proper management, quality of life can be improved.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Noonan syndrome is an inherited genetic disorder characterized by a variety of clinical features, including characteristic physiognomic features, insufficient growth height, and birth defects.<\/p>","protected":false},"author":1,"featured_media":21331,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12282","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12282","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12282"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12282\/revisions"}],"predecessor-version":[{"id":14797,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12282\/revisions\/14797"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21331"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12282"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12282"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12282"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}