{"id":12259,"date":"2025-01-14T17:01:16","date_gmt":"2025-01-14T16:01:16","guid":{"rendered":"https:\/\/valintermed.com\/?p=12259"},"modified":"2025-01-14T17:01:17","modified_gmt":"2025-01-14T16:01:17","slug":"nefrokaltsinoz","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/","title":{"rendered":"Nephrocalcinosis"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Nephrocalcinosis is a pathological condition characterized by calcium deposition in kidney tissue. This can lead to dysfunction of the organs, as well as various complications, including renal failure. Nephrocalcinosis can be caused by metabolic disorders, as well as concomitant diseases, such as chronic urinary tract infections or parathyroid diseases. The pathology can develop against the background of hypercalcemia, hypercalciuria or other metabolic dysfunctions. Nephrocalcinosis can remain asymptomatic for a long time or manifest itself with pain syndrome, difficulty urinating and other acute symptoms.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/nephrocalcinosis\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nephrocalcinosis has a long history, beginning with the first descriptions in medical literature. In the 19th century, when active study of kidney diseases began, doctors began to identify symptoms associated with the accumulation of minerals inside the organ. One of the first researchers of this disease was the German pathologist Victor Heinick, who in 1854 described the clinical manifestations and morphological changes associated with nephrocalcinosis. Later, in the early 20th century, with the development of imaging methods and laboratory diagnostics, the understanding of the etiology and pathogenesis of this condition significantly improved. Historical studies show that nephrocalcinosis occurs in people of various age groups, but its increase in the population is associated with the development of technology and improved diagnostics, which allows identifying this condition at earlier stages of its development.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nephrocalcinosis is a relatively rare disease, and its prevalence varies depending on the region and comorbidities in the population. According to statistics, its incidence is from 1 to 5 cases per 1000 people, which is quite low. However, it should be taken into account that nephrocalcinosis is more often diagnosed in patients with certain chronic diseases, such as primary hyperparathyroidism or chronic kidney disease, which increases the likelihood of its detection in these groups. Some studies suggest that nephrocalcinosis is more common in older people, which may be due to age-related changes in metabolism and functional capacity of the kidneys. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Scientific research shows that genetic predisposition may play a significant role in the development of nephrocalcinosis. In particular, mutations in genes responsible for calcium and phosphorus metabolism may contribute to the development of this pathology. The main genes involved in calcium metabolism processes are:<\/p>\n<ul>\n<li>CASR (Calcium Sensory Receptor) Gene<\/li>\n<li>CYP24A1 gene (oncological gene associated with vitamin D metabolism)<\/li>\n<li>SLC34A1 gene (coordinates phosphate transport)<\/li>\n<\/ul>\n<p>Changes in these genes can lead to hypercalcemia or hypercalciuria, which in turn can contribute to the formation of calcium deposits in the kidneys. However, it is important to remember that genetic predisposition is only one factor influencing the development of nephrocalcinosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>There are many risk factors that can contribute to the development of nephrocalcinosis. These include:<\/p>\n<ul>\n<li>Metabolic disorders such as primary hyperparathyroidism or Fanconi syndrome.<\/li>\n<li>Chronic urinary tract infections, which can cause inflammation and calcium deposits.<\/li>\n<li>Long-term therapy with certain medications, such as diuretics.<\/li>\n<li>Disorders of calcium and vitamin D metabolism.<\/li>\n<li>Specific genetic predispositions.<\/li>\n<\/ul>\n<p>In addition, the presence of underlying diseases such as diabetes or liver disease increases the risk of developing nephrocalcinosis. Poor nutrition, such as high calcium and phosphate levels in the diet, can also further contribute to its occurrence.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of nephrocalcinosis is based on a combination of clinical symptoms and the results of laboratory and instrumental studies. The main symptoms of the disease include:<\/p>\n<ul>\n<li>Pain in the lower back or kidney area.<\/li>\n<li>Dysurposition, including hematuria and dysuria.<\/li>\n<li>General and local manifestations such as swelling or increased blood pressure.<\/li>\n<li>Fatigue and weakness.<\/li>\n<\/ul>\n<p>Laboratory tests may include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>General urine analysis to detect blood and crystals.<\/li>\n<li>Biochemical blood test to determine levels of calcium, phosphates and vitamin D.<\/li>\n<li>Analysis of parathyroid hormone levels.<\/li>\n<\/ul>\n<p>Radiological studies such as ultrasound or computed tomography (CT) are key in visualizing calcium deposits in the kidneys. These studies allow us to assess the extent of nephrocalcinosis and its possible complications. The differential diagnosis includes the need to exclude other causes of kidney pain such as stones or tumors.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment for nephrocalcinosis depends on the etiology and severity of the disease. General treatment approaches may include:<\/p>\n<ul>\n<li>Extracorporeal lithotripsy in the presence of large calcium deposits.<\/li>\n<li>Detoxification of the body from excess calcium and correction of metabolism with the help of diet and medications.<\/li>\n<li>Pharmacological treatment, including the use of diuretics or drugs that regulate calcium and phosphate metabolism.<\/li>\n<\/ul>\n<p>Pharmacological treatment may range from vitamin D and magnesium supplements to more serious interventions depending on the progression of the disease. Surgical treatment may be recommended when large calcified masses form that interfere with normal kidney function. <\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The most commonly used medications for the treatment of nephrocalcinosis include:<\/p>\n<ul>\n<li>Calcitriol (active form of vitamin D)<\/li>\n<li>Phosphates (to correct phosphorus levels in the body)<\/li>\n<li>Diuretics such as furosemide (to reduce calcium recirculation)<\/li>\n<li>Bisphosphonates (to lower blood calcium levels)<\/li>\n<\/ul>\n<p>Supplementing therapy with vitamins and minerals may also be helpful.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring a patient with nephrocalcinosis is an important part of treatment and involves regular follow-up tests and examinations. Key monitoring steps include:<\/p>\n<ul>\n<li>Regular monitoring of calcium levels in the blood and urine.<\/li>\n<li>Periodic ultrasound examinations to assess the condition of the kidneys.<\/li>\n<li>Monitor for possible signs of worsening condition.<\/li>\n<\/ul>\n<p>The prognosis with timely diagnosis and adequate treatment is usually favorable, but advanced cases can lead to complications such as chronic renal failure or recurrent infections.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Nephrocalcinosis may present differently depending on the patient\u2019s age. In children and adolescents, the disease is often associated with hereditary or metabolic disorders, while in adults it is more common in the case of concomitant chronic diseases. In the elderly, nephrocalcinosis develops against the background of age-related changes, which can complicate diagnosis and treatment. Given the different age categories, the approach to treatment and monitoring should be adapted to the individual characteristics of each patient.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What are the main symptoms of nephrocalcinosis?<\/strong> The main symptoms include lower back pain, difficulty urinating, and possible manifestations of general intoxication such as weakness and fatigue.<\/li>\n<li><strong>Can the development of nephrocalcinosis be prevented?<\/strong> In some cases, the development of the disease can be prevented by adjusting the diet and controlling the metabolism of calcium and phosphates in the body.<\/li>\n<li><strong>How long does it take for nephrocalcinosis to develop?<\/strong> The disease can develop over many years, often remaining asymptomatic until significant calcium deposits develop.<\/li>\n<li><strong>What diagnostic methods are used to detect nephrocalcinosis?<\/strong> The main diagnostic methods include a general urine analysis, a biochemical blood test, and various imaging studies such as ultrasound or CT scan.<\/li>\n<li><strong>What is the main cause of nephrocalcinosis?<\/strong> The underlying cause may be metabolic disturbances including hypercalcemia and hypercalciuria, as well as chronic kidney disease.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Nephrocalcinosis is a pathological condition characterized by the deposition of calcium in the kidney tissue. This can lead to organ dysfunction, as well as<\/p>","protected":false},"author":1,"featured_media":21240,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12259","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12259"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12259\/revisions"}],"predecessor-version":[{"id":14851,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12259\/revisions\/14851"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21240"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12259"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12259"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}