{"id":12243,"date":"2025-01-14T17:20:54","date_gmt":"2025-01-14T16:20:54","guid":{"rendered":"https:\/\/valintermed.com\/?p=12243"},"modified":"2025-01-14T17:20:54","modified_gmt":"2025-01-14T16:20:54","slug":"nekrotiziruyuschiy-vaskulit","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/","title":{"rendered":"Necrotizing vasculitis"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Necrotizing vasculitis is a group of rare systemic diseases characterized by inflammation and necrosis of the vascular wall, which leads to disruption of the blood supply to organs and tissues. This disease can affect both small and large vessels, depending on the clinical form of vasculitis. An important aspect of necrotizing vasculitis is its autoimmune nature, where the immune system mistakenly begins to attack its own vessels, leading to their damage. The clinical picture can vary from a mild skin rash to severe systemic manifestations and organ failure.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewbox=\"0 0 24 24\" version=\"1.2\" baseprofile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 eztoc-toggle-hide-by-default' ><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/necrotizing-vasculitis\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Necrotizing vasculitis was first mentioned in the early 20th century when clinicians began to notice systemic manifestations associated with vascular inflammation. In the 1940s, prominent physicians such as Dixon and Fox described various clinical aspects of the disease, including its association with infections and allergens. In the 1950s, case studies were improved by the introduction of serologic markers and vessel biopsy. Interestingly, the term vasculitis was first used in 1950 to describe a wide range of diseases with underlying vascular pathology. In the following decades, developments in immunoassays and genetic studies have greatly expanded our understanding of the mechanisms underlying this complex disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to epidemiological studies, necrotizing vasculitis occurs with a frequency of 10-30 cases per 100,000 people per year. Most often, the disease affects people aged 40 to 70 years, but it can also occur in children. Men and women are affected with approximately the same frequency, but clinical manifestations may differ. Different forms of vasculitis have their own epidemiological features: for example, granulomatosis with polyangiitis is more common in women, while cryoglobulinemic vasculitis may be associated with the hepatitis C virus and is more common in men. These statistics highlight the need for further research to better understand the epidemiology of necrotizing vasculitis and the factors influencing its occurrence.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Studies show that genetic predisposition may play a significant role in the development of necrotizing vasculitis. In particular, associations have been identified between this disease and certain alleles of the HLA gene. Mutations in genes such as PTPN22, STAT4, and PADI4 may also increase the risk of developing inflammatory diseases, including necrotizing vasculitis. It is important to note that genetic predisposition is not the only factor; patients also have external triggers such as infections, smoking, and the use of certain medications. This multifactorial interaction confirms the complex pathogenesis of the disease and the need for a comprehensive approach to its medical assessment and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors associated with the development of necrotizing vasculitis include:<\/p>\n<ul>\n<li>Infectious agents such as viruses and bacteria.<\/li>\n<li>Smoking and exposure to toxic chemicals.<\/li>\n<li>Certain medications, including antibiotics and nonsteroidal anti-inflammatory drugs.<\/li>\n<li>Autoimmune and systemic diseases such as systemic lupus erythematosus or rheumatoid arthritis.<\/li>\n<li>Psycho-emotional stress and trauma can also act as triggers.<\/li>\n<\/ul>\n<p>These factors help create a pattern that may precede the development of vasculitis, highlighting the importance of early diagnosis and monitoring of health conditions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of necrotizing vasculitis is based on clinical symptoms, laboratory tests and instrumental methods. The main symptoms may include:<\/p>\n<ul>\n<li>Skin manifestations: exanthema, purpura, ulcers.<\/li>\n<li>Systemic manifestations: fever, weakness, weight loss.<\/li>\n<li>Organ damage: pain in the joints, muscles, as well as from the respiratory system and kidneys.<\/li>\n<\/ul>\n<p>Laboratory tests typically include:<\/p>\n<ul>\n<li>Complete blood count to detect anemia and leukocytosis.<\/li>\n<li>Determination of the level of C-reactive protein and other inflammatory markers.<\/li>\n<li>Serological tests for the presence of antinuclear antibodies and specific antibodies (ANCA, anti-GBM).<\/li>\n<\/ul>\n<p>Radiological examinations include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Ultrasound of organs to assess the condition of the kidneys.<\/li>\n<li>CT and MRI for visualization of vascular changes and complications.<\/li>\n<\/ul>\n<p>Other types of diagnostics may include biopsy of the affected tissues, which allows for confirmation of the diagnosis through histological examination. It is also important to conduct differential diagnosis with other concomitant diseases, such as infectious or oncological processes, which requires high qualification of the doctor.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of necrotizing vasculitis depends on its clinical form, severity, and organs involved. General approaches to therapy include:<\/p>\n<ul>\n<li>Avoiding triggers for the disease, such as stopping smoking or treating infections.<\/li>\n<li>Immunosuppressant drugs such as corticosteroids, eg prednisolone.<\/li>\n<li>Cytostatic drugs such as methotrexate or azathioprine are used to control infection and reduce the inflammatory response.<\/li>\n<li>Biologic agents such as rituximab are used when traditional treatments are ineffective.<\/li>\n<li>Surgery may be required to treat complications such as tissue or vascular necrosis.<\/li>\n<\/ul>\n<p>Thus, a comprehensive approach to treatment allows for effective control of the disease and improvement of the patient\u2019s quality of life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main medications used in the treatment of necrotizing vasculitis include:<\/p>\n<ul>\n<li>Corticosteroids (prednisolone, methylprednisolone);<\/li>\n<li>Cytostatics (methotrexate, azathioprine)<\/li>\n<li>Biological drugs (rituximab, tocilizumab)<\/li>\n<li>Infusion drugs (IV immunoglobulin)<\/li>\n<li>Nonsteroidal anti-inflammatory drugs (Ibuprofen, Naproxen);<\/li>\n<\/ul>\n<p>Each of these drugs has its own indications and limitations in use, which requires careful medical evaluation for each patient.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of a patient with necrotizing vasculitis includes regular follow-up examinations, assessment of inflammatory markers, and function of affected organs. The prognosis with early diagnosis and adequate treatment can be favorable; many patients achieve remission. However, possible complications such as renal failure, pulmonary changes, and systemic disorders must be taken into account, which can significantly reduce the quality of life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Necrotizing vasculitis may present differently depending on the age group. In children, the disease may be aggressive and require special attention, while older patients often have less severe symptoms, but the likelihood of comorbidities increases, which may complicate treatment. Adult patients are more likely to suffer from systemic manifestations, such as kidney and lung damage, which also requires an individual approach to therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is necrotizing vasculitis?<\/strong> It is an autoimmune disease characterized by inflammation and necrosis of blood vessels, which can lead to serious damage to organs and tissues.<\/li>\n<li><strong>What are the main symptoms of the disease?<\/strong> Symptoms include skin rashes, fever, weight loss, as well as joint pain and possible damage to internal organs.<\/li>\n<li><strong>What factors can contribute to the development of necrotizing vasculitis?<\/strong> Infections, smoking, toxic substances, and the presence of other autoimmune diseases may increase the risk.<\/li>\n<li><strong>What diagnostic methods are used?<\/strong> Diagnosis includes clinical examination, laboratory tests, radiological examinations and biopsy.<\/li>\n<li><strong>What are the principles of treatment?<\/strong> Treatment includes the use of corticosteroids, cytostatics and biological drugs, as well as possible surgical intervention in complex cases.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Necrotizing vasculitis is a group of rare systemic diseases characterized by inflammation and necrosis of the vascular wall, which leads to a disruption of the blood supply to organs.<\/p>","protected":false},"author":1,"featured_media":21197,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12243","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12243","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12243"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12243\/revisions"}],"predecessor-version":[{"id":14867,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12243\/revisions\/14867"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/21197"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12243"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12243"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12243"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}