{"id":12115,"date":"2025-03-13T21:40:22","date_gmt":"2025-03-13T20:40:22","guid":{"rendered":"https:\/\/valintermed.com\/?p=12115"},"modified":"2025-03-13T21:40:22","modified_gmt":"2025-03-13T20:40:22","slug":"mukopolisaharidoz-1-tipa-mps-i-sindrom-gurler","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/mukopolisaharidoz-1-tipa-mps-i-sindrom-gurler\/","title":{"rendered":"Mucopolysaccharidosis type 1 (MPS I, Hurler syndrome)"},"content":{"rendered":"
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Mucopolysaccharidosis type 1 (MPS I), also known as Hurler syndrome, is a rare inherited disorder belonging to the group of mucopolysaccharidoses, characterized by a deficiency of the enzyme alpha-iduronidase. This leads to the accumulation of mucopolysaccharides, which have a toxic effect on cells, which in turn causes a variety of pathological changes in organs and tissues. The disease manifests itself at various stages of development and can have a wide range of clinical manifestations, including disorders of the cardiovascular, respiratory, musculoskeletal and nervous systems. Hurler syndrome causes significant impairment of the quality of life of patients and has serious complications, including a decrease in life expectancy.<\/p>\n

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