{"id":12109,"date":"2025-03-13T21:43:20","date_gmt":"2025-03-13T20:43:20","guid":{"rendered":"https:\/\/valintermed.com\/?p=12109"},"modified":"2025-03-13T21:43:20","modified_gmt":"2025-03-13T20:43:20","slug":"monomelicheskaya-amiotrofiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/","title":{"rendered":"Monomelic amyotrophy"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Monomelic amyotrophy, also known as Benedict&#039;s syndrome, is a rare neurological disorder characterized by progressive muscle wasting, usually in one limb. It is a motor neuron disorder characterized by isolated muscle weakness due to degeneration of the anterior ronary neurons that supply the muscles. Monomelic amyotrophy typically begins with weakness of the shoulder or leg muscles, which in later stages leads to significant atrophy. Clinical manifestations may vary, but the main symptom is asymmetric weakness, which may progress to more severe forms of motor impairment. The disorder typically affects adults and is most often seen in men, highlighting the importance of studying the etiology and pathogenesis of the disease.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/monomelicheskaia-amyotrophia\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monomelic amyotrophy was first described in the late 19th century, although the symptoms of the disease may have been known earlier. In 1876, French neurologist Jean-Martin Charcot commented on observations of progressive muscle atrophy, emphasizing that the condition could affect individual limbs. Almost a century later, in the 1960s, the disease became more widely studied due to increased knowledge of the structural changes in neurons and the mechanisms underlying the atrophy. In recent decades, there has been interest in monomelic amyotrophy as a distinct nosological entity, distinct from other motor neuron diseases such as amyotrophic lateral sclerosis. Research continues, with scientists seeking to understand the molecular mechanisms that lead to the pathology and to develop new approaches to diagnosis and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Statistics show that monomelic amyotrophy is rare. It is estimated that the disease affects approximately 1-2 people per 100,000 population. However, this figure may vary depending on geographic location and ethnicity. In particular, men are at higher risk of developing monomelic amyotrophy than women, suggesting possible hormonal or genetic influences. The disease is most often diagnosed in middle-aged people, with a peak incidence in the 40s-60s. Because the disease may be initially misdiagnosed due to similar symptoms to other neurological disorders, the actual incidence may be higher. Most studies suggest that monomelic amyotrophy is an autoimmune disorder, adding complexity to the epidemiology and prognosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The role of genetic factors in the development of monomelic amyotrophy is currently being investigated. Studies are being conducted to identify genes that may be associated with this disease. The description of mutations in genes such as SOD1, C9orf72 and others has received attention in the context of similar diseases such as amyotrophic lateral sclerosis. However, a direct link between these genes and monomelic amyotrophy is still a subject of research. Researchers point to the possibility of a polygenic predisposition, where a number of unclassified genetic variations may increase the risk of developing the disease in combination with environmental factors. Molecular genetic studies using next-generation sequencing (NGS) technology are opening up new horizons for elucidating the mechanisms behind this pathology.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Since monomelic amyotrophy is considered a complex disease, risk factors include both genetic predisposition and external influences. The following groups of risk factors exist:<\/p>\n<ul>\n<li>Physical factors: Injuries and physical activity that lead to microtraumas of muscles and nerves can trigger manifestations of the disease.<\/li>\n<li>Chemical factors: Exposure to toxic substances such as heavy metals or organic solvents can contribute to neuronal damage.<\/li>\n<li>Immune factors: Diseases that adversely affect the immune system can cause autoimmune reactions leading to neuronal degeneration.<\/li>\n<li>Infectious factors: Some viral infections, such as herpes viruses, can provoke inflammatory processes in the nervous system, which can further contribute to the development of the disease.<\/li>\n<\/ul>\n<p>The specific effects of each of these factors may vary, but their combined effects may increase the risk of developing monomelic amyotrophy in susceptible individuals.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of monomelic amyotrophy is based on a thorough medical history, clinical examination and specialized laboratory tests. The main symptoms to look out for include:<\/p>\n<ul>\n<li>Asymmetric weakness, most often in one limb;<\/li>\n<li>Muscle atrophy that develops over several months;<\/li>\n<li>Decreased reflexes on the affected side;<\/li>\n<li>No sensory impairment.<\/li>\n<\/ul>\n<p>Laboratory tests include a complete blood count, biochemistry panel, which can help rule out other diseases. Electromyography and neurography play an important role in assessing motor neuron function. Radiological examinations such as MRI can be used to rule out other structural diseases. It is also important to conduct a differential diagnosis to rule out conditions such as diabetes mellitus, spinal muscular atrophy, amyotrophic lateral sclerosis, and other neurological disorders.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of monomelic amyotrophy is largely symptomatic, since no specific etiotropic treatment has been developed at present. General approaches to treatment include:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li>Pharmacological treatment aimed at relieving symptoms, such as the use of nonsteroidal anti-inflammatory drugs;<\/li>\n<li>Physiotherapy to maintain muscle tone and improve limb function;<\/li>\n<li>Surgical treatment if there are secondary complications - for example, in the case of contractures;<\/li>\n<li>Psychological support and rehabilitation to improve the quality of life of patients.<\/li>\n<\/ul>\n<p>The effectiveness of treatment may vary from patient to patient, so an individual approach is required.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>At this stage, specific drugs for the treatment of monomelic amyotrophy have not been developed, but some drugs are used as maintenance therapy:<\/p>\n<ul>\n<li>Riluzole - for neuroprotection;<\/li>\n<li>If necessary, non-steroidal anti-inflammatory drugs (eg, ibuprofen, diclofenac);<\/li>\n<li>Muscle relaxants to relieve spasticity (eg, cyclobenzaprine);<\/li>\n<li>A complex of B vitamins to support the nervous system.<\/li>\n<\/ul>\n<p>These agents are used to provide symptomatic relief and improve the patient&#039;s quality of life.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with monomelic amyotrophy should include regular examinations to assess disease progression. Key monitoring steps include:<\/p>\n<ul>\n<li>Regular assessment of muscle functionality;<\/li>\n<li>Psychological and social aspects of the patient&#039;s life;<\/li>\n<li>Assessing the need for physical therapy and other interventions;<\/li>\n<li>Prognosis of complications such as contractures and movement disorders.<\/li>\n<\/ul>\n<p>The prognosis of monomelic amyotrophy depends largely on the degree of muscle atrophy and loss of function. Complications may include pain associated with musculoskeletal problems, as well as emotional disturbances.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monomelic amyotrophy may have different patterns depending on the age group. In adults, the disease usually manifests itself as isolated muscle weakness with slow progression. In older patients, symptoms may develop more quickly. In children, such cases are extremely rare, but when the disease occurs, it manifests itself more aggressively, which requires special attention from specialists.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is the main cause of monomelic amyotrophy?<\/strong> The underlying cause of monomelic amyotrophy is currently unknown, but it is believed that the disease may be associated with autoimmune processes or traumatic nerve damage.<\/li>\n<li><strong>What are the symptoms of monomelic amyotrophy?<\/strong> The main symptoms include asymmetric muscle weakness, atrophy and decreased reflexes on the affected side, while sensory nerve symptoms are absent.<\/li>\n<li><strong>How is the disease diagnosed?<\/strong> Diagnosis includes clinical examination, electro- and neuromyography, as well as radiological studies to exclude other diseases.<\/li>\n<li><strong>What is the treatment for monomelic amyotrophy?<\/strong> Treatment is mainly symptomatic and includes medications, physical therapy and, in some cases, surgery.<\/li>\n<li><strong>What is the prognosis for patients with monomelic amyotrophy?<\/strong> The prognosis for patients may vary depending on the degree of muscle atrophy; complications from the musculoskeletal system are possible.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Monomelic amyotrophy, also known as Benedict&#039;s syndrome, is a rare neurological disorder characterized by progressive muscle wasting, usually in one limb.<\/p>","protected":false},"author":1,"featured_media":20910,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12109","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12109"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12109\/revisions"}],"predecessor-version":[{"id":15011,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12109\/revisions\/15011"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/20910"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}