{"id":12050,"date":"2025-03-13T23:42:38","date_gmt":"2025-03-13T22:42:38","guid":{"rendered":"https:\/\/valintermed.com\/?p=12050"},"modified":"2025-03-13T23:42:38","modified_gmt":"2025-03-13T22:42:38","slug":"metilmalonovaya-atsidemiya-s-gomotsistinuriey","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/","title":{"rendered":"Methylmalonic acidemia with homocystinuria"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Methylmalonic acidemia with homocystinuria (MMH) is a rare inherited metabolic disorder characterized by impaired vitamin B12 metabolism and a significant increase in the concentration of methylmalonic acid and homocysteine in the body. This leads to a wide range of clinical manifestations, including neurological disorders, developmental delay, cardiovascular disorders and other metabolic dysfunctions. The disease is caused by genetic mutations affecting various metabolic pathways, which leads to the accumulation of toxic compounds. The condition requires strict monitoring and management, since untimely diagnosis and treatment can lead to serious complications, including death.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of drugs used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/methylmalonate-atsidemiya-s-gomotsistinuriey\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Methylmalonic acidemia was first described in the medical literature in the mid-20th century. The first cases of the disease became known due to the attention to the problems of metabolic genetics that was developing at that time. In the 1960s, scientists began to recognize the connection between various forms of acidemia and vitamin B12 deficiency, which led to a deeper understanding of the genetic basis of the disease. Interestingly, in the 1970s, specific mutations responsible for the manifestations of methylmalonic acidemia were identified, which was a significant step towards understanding the mechanism of the disease. Since then, active research has been conducted to identify new genetic markers and ways to treat MMA.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Methylmalonic acidemia with homocystinuria is a rare disorder with a variable incidence among populations. Statistically, the disorder occurs in approximately 1 in 50,000 to 100,000 live births. The epidemiology of MMA shows considerable geographic variability. For example, some communities in Northern Europe have a higher incidence, which may be due to genetic predisposition and increased mutation incidence in related populations. Globally, estimates of the prevalence of homocystinuria also suggest a low incidence, but accurate data are difficult to obtain due to the limited availability of screening programs.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>MMG is hereditary, most often transmitted in an autosomal recessive manner. The main genes involved in the development of the disease include MCM6, MUT and others, specifically responsible for the fixation and processing of methylmalonic acid and vitamin B12. Mutations in these genes can lead to the development of various forms of the disease, while the type of gene involved in the mutation can determine the clinical picture and the severity of symptoms. It is important to note that the existence of identical mutations can lead to different clinical manifestations, which sometimes complicates the diagnosis of the disease and its prognosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Risk factors for developing methylmalonic acidemia with homocystinuria are mainly related to genetic predisposition, which makes consanguineous marriages especially dangerous in terms of increasing the likelihood of developing the disease. Risk factors include the following:<\/p>\n<ul>\n<li>Presence of relatives with metabolic disorders (to identify cases in the family).<\/li>\n<li>Genetic mutations in populations with increased incidence (eg, in certain ethnic groups).<\/li>\n<li>Lack of preventive genetic testing during pregnancy.<\/li>\n<\/ul>\n<p>Additionally, secondary factors such as living conditions, access to health care, and availability of screening programs may also influence diagnosis and early intervention.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of methylmalonic acidemia involves a range of approaches, from clinical symptoms to laboratory and instrumental studies. The most common signs of the disease usually appear at an early age and may include:<\/p>\n<ul>\n<li>Neurological disorders (tremor, developmental delay).<\/li>\n<li>Symptoms of digestive system disorders (vomiting, refusal to eat).<\/li>\n<li>Metabolic crises with the development of acidosis.<\/li>\n<\/ul>\n<p>Laboratory tests needed to confirm the diagnosis include:<\/p>\n<ul>\n<li>Measurement of methylmalonic acid levels in urine.<\/li>\n<li>Determination of homocysteine levels in blood plasma.<\/li>\n<li>Blood test for levels of vitamin B12 and its active form, methylcobalamin.<\/li>\n<\/ul>\n<p>Radiological examinations such as ultrasound and CT can be used to detect associated pathologies, such as changes in abdominal organs. It is important to differentiate from other metabolic disorders such as homocystinuria, carbohydrate and lipid dysfunctions to avoid misdiagnosis and inappropriate treatment.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of methylmalonic acidemia requires a multidisciplinary approach, including nutritional support, pharmacological interventions, and specific treatments. Key aspects of overall treatment include:<\/p>\n<ul>\n<li>A special low protein diet to reduce methylmalonic acid levels.<\/li>\n<li>Taking B vitamins (particularly B12) to compensate for the deficiency.<\/li>\n<li>In some cases, the use of specialized forms of products enriched with cobalamins.<\/li>\n<\/ul>\n<p>Pharmacological treatment may include medications that lower blood levels of methylmalonic acid and homocysteine. Surgical treatment may be necessary in cases of serious complications, such as resection of affected areas.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of drugs used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main drugs used to treat methylmalonic acidemia with homocystinuria include:<\/p>\n<ul>\n<li>Vitamin B12 (mucobalamin) for the correction of metabolic disorders.<\/li>\n<li>Levocarnitine to improve fatty acid metabolism.<\/li>\n<li>Folic acid preparations.<\/li>\n<\/ul>\n<p>Additionally, drugs may be used to correct individual metabolic disorders, such as amino acid mixtures with low methionine content.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of methylmalonic acidemia includes regular follow-up examinations to assess the effectiveness of treatment, the level of metabolites in the blood and urine, and to identify possible complications. <\/p>\n<ul>\n<li>Monitor blood levels of methylmalonic acid and homocysteine on a regular basis.<\/li>\n<li>Prescribing periodic examinations to assess the functional state of organs.<\/li>\n<li>Comparative analysis of the child&#039;s health status taking into account his age category.<\/li>\n<\/ul>\n<p>The prognosis depends on timely diagnosis and treatment: the earlier therapy begins, the higher the probability of achieving a stable condition and preventing serious complications such as thrombosis or cardiovascular disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Methylmalonic acidemia may present differently depending on the patient\u2019s age. Neonates are more likely to experience severe symptoms such as seizures and metabolic crises, while older children may have milder symptoms but are at increased risk of developing chronic complications. Adult patients may experience long-term metabolic disturbances that lead to decreased quality of life and difficulty with work. In the elderly, methylmalonic acidemia may be aggravated by comorbidities, which also requires special attention in terms of treatment and monitoring.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is the main manifestation of methylmalonic acidemia?<\/strong> The main manifestations include neurological disorders, developmental delays and metabolic crises.<\/li>\n<li><strong>What laboratory tests are needed to diagnose the disease?<\/strong> For diagnosis, it is necessary to conduct tests for the level of methylmalonic acid and homocysteine in the blood and urine, as well as determination of vitamin B12.<\/li>\n<li><strong>Is it possible to completely cure methylmalonic acidemia?<\/strong> Currently, the disease cannot be completely cured, but proper treatment can significantly improve quality of life and reduce the level of toxic metabolites.<\/li>\n<li><strong>What is the prognosis for patients with methylmalonic acidemia?<\/strong> The prognosis depends on early diagnosis and initiation of treatment; in most cases, patients can lead an active lifestyle if they follow the doctor&#039;s recommendations.<\/li>\n<li><strong>Is a special diet needed for methylmalonic acidemia?<\/strong> Yes, a low protein diet is an important part of treatment to reduce toxic levels in the body.<\/li>\n<\/ul>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Methylmalonic acidemia with homocystinuria (MMH) is a rare inherited metabolic disorder characterized by impaired vitamin B12 metabolism and a significant increase<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12050","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12050","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12050"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12050\/revisions"}],"predecessor-version":[{"id":15070,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12050\/revisions\/15070"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12050"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12050"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12050"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}