{"id":12047,"date":"2025-03-13T23:58:58","date_gmt":"2025-03-13T22:58:58","guid":{"rendered":"https:\/\/valintermed.com\/?p=12047"},"modified":"2025-03-13T23:58:58","modified_gmt":"2025-03-13T22:58:58","slug":"metahromaticheskaya-leykodistrofiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/metachromatic-leukodystrophia\/","title":{"rendered":"Metachromatic leukodystrophy"},"content":{"rendered":"
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Metachromatic leukodystrophy (MLD) is a rare inherited neurodegenerative disorder that belongs to the leukodystrophies. It is characterized by the progressive destruction of myelin, the protective sheath of nerve cells, which leads to disruption of nerve impulse transmission in the central and peripheral nervous system. Signs of the disease usually begin in childhood, although there are a number of forms that manifest in adulthood. The main cause of metachromatic leukodystrophy is a mutation in the ARSA gene, which leads to a deficiency of arylsulfatase A, an enzyme responsible for breaking down certain lipids.<\/p>\n

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