{"id":12007,"date":"2025-04-18T11:16:10","date_gmt":"2025-04-18T09:16:10","guid":{"rendered":"https:\/\/valintermed.com\/?p=12007"},"modified":"2025-04-18T11:16:10","modified_gmt":"2025-04-18T09:16:10","slug":"malakoplakiya","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/","title":{"rendered":"Malakoplakia"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Malakoplakia is a rare inflammatory disease characterized by the formation of granulomas and necrotic areas in various organs and tissues, most often in the urinary tract and intestines. The pathology is associated with a violation of the immune response to infections, in particular, caused by bacteria of the genus Escherichia coli and other pathogens. The disease manifests itself as local or systemic inflammation, which can lead to quite serious complications if adequate treatment is not undertaken in time. Clinical manifestations of malakoplakia vary depending on the localization of the process, and may include pain, dyspuria, and various systemic symptoms such as fever and weight loss.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/malakoplakiya\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Malakoplakia was first described in 1902 by the German pathologist L. Kalf. He described the disease as a pathogenic change in the bladder of a patient suffering from a chronic infection. Since then, malakoplakia has attracted the attention of not only medical professionals, but also historians. One of the most famous stories is the case of a manufacturing worker in the 1970s whose symptoms were mistaken for age-related changes, indicating the need for a more detailed study of the clinical manifestations and diagnosis of malakoplakia. In the following decades, numerous studies have been conducted that have helped to clarify the mechanisms of pathogenesis and diagnosis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Malakoplakia is considered a rare disease, but its prevalence among different populations varies significantly depending on the region and social conditions. Malakoplakia is most often observed in adults, while its incidence in pediatric practice is much lower. According to various epidemiological studies, the incidence ranges from 0.1 to 2 cases per 100,000 population per year. The prevalence of the disease among women is noted compared to men, which may be due to the anatomical features of the female genitourinary system.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>To date, studies have shown that genetic predisposition to malakoplakia may be associated with certain mutations in genes responsible for the immune response. In particular, there are a number of polymorphisms in genes encoding cytokines and their receptors, such as IL-1, IL-6, and TNF-\u03b1. These mutations can lead to disruption of the normal functioning of the immune system, which in turn increases the risk of developing inflammatory processes such as malakoplakia. Data on the heritability of the disease are limited, but there is an opinion about the possible role of these genes in pathogenesis.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Among the risk factors that contribute to the development of malakoplachia, the following can be distinguished:<\/p>\n<ul>\n<li>Chronic urinary tract infections.<\/li>\n<li>Immunodeficiencies such as HIV infection or use of immunosuppressive therapy.<\/li>\n<li>The presence of concomitant diseases such as diabetes.<\/li>\n<li>Old age, which is associated with general immune dysfunction.<\/li>\n<li>Constant contact with toxic chemicals, which increases the risk of inflammatory processes.<\/li>\n<\/ul>\n<p>These risk factors create a predisposition to malakoplachia, but are not a causal factor in themselves, but act in combination with other conditions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of malakoplachia requires a comprehensive approach and includes the following steps:<\/p>\n<ul>\n<li><strong>Main symptoms:<\/strong> frequent and painful urination, abdominal pain, fever, loss of appetite and weight.<\/li>\n<li><strong>Laboratory tests:<\/strong> urine analysis, determination of the level of inflammatory markers (for example, C-reactive protein).<\/li>\n<li><strong>Radiological examinations:<\/strong> Ultrasound, CT, and MRI of the abdominal organs can help identify granulomas and other changes.<\/li>\n<li><strong>Other types of disease diagnostics:<\/strong> Endoscopic tests such as cystoscopy may be needed to visualize the affected area.<\/li>\n<li><strong>Differential diagnosis:<\/strong> It is necessary to exclude other diseases such as bladder cancer, tuberculosis or other infectious processes.<\/li>\n<\/ul>\n<p>Thus, early diagnosis of malakoplachia is an important factor in the timely initiation of treatment and prevention of complications.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of malakoplachia requires an individual approach and may include both conservative and surgical methods:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li><strong>General treatment:<\/strong> if necessary, correction of concomitant diseases (for example, control of sugar levels in diabetes).<\/li>\n<li><strong>Pharmacological treatment:<\/strong> broad-spectrum antibiotics when an infectious process is detected, anti-inflammatory drugs to relieve the inflammatory response.<\/li>\n<li><strong>Surgical treatment:<\/strong> may be necessary in case of formation of large granulomas requiring removal.<\/li>\n<li><strong>Other types of treatment:<\/strong> Physiotherapy procedures can be used to improve the overall condition of the body and stimulate the immune response.<\/li>\n<\/ul>\n<p>The effectiveness of treatment depends on early diagnosis and individual characteristics of the patient.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The medications used to treat malakoplachia include:<\/p>\n<ul>\n<li>Ciprofloxacin<\/li>\n<li>Levofloxacin<\/li>\n<li>Trimethoprim\/Sulfamethoxazole<\/li>\n<li>Nonsteroidal anti-inflammatory drugs (NSAIDs)<\/li>\n<li>Immunomodulatory agents (eg, interleukins)<\/li>\n<\/ul>\n<p>These drugs help control infection and inflammation, which is a key element in the treatment of malakoplachia.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring the course of the disease includes:<\/p>\n<ul>\n<li>Regular check-ups with a doctor to assess the patient&#039;s condition and the dynamics of the disease.<\/li>\n<li>Laboratory tests to assess levels of inflammatory markers.<\/li>\n<li>Monitoring the function of affected organs to prevent serious complications.<\/li>\n<li>The prognosis of the disease is usually favorable with timely diagnosis and adequate treatment.<\/li>\n<li>Complications may include the development of kidney failure if treatment is not started in time.<\/li>\n<\/ul>\n<p>Proper monitoring allows for timely detection of changes in the patient\u2019s condition and adjustment of treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Malakoplakia may present differently depending on the patient&#039;s age group:<\/p>\n<ul>\n<li><strong>Children:<\/strong> Most often, malakoplakia is detected as an isolated case, but with a certain tendency to associated infections.<\/li>\n<li><strong>Teenagers:<\/strong> Exacerbations associated with puberty and changes in immune status are possible.<\/li>\n<li><strong>Adults:<\/strong> The highest incidence is observed in this group, especially among older people with concomitant diseases.<\/li>\n<li><strong>Elderly people:<\/strong> In this group, the disease may be more severe and require active monitoring of concomitant pathological conditions.<\/li>\n<\/ul>\n<p>Each age group requires an individual approach to diagnosis and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is malakoplakia?<\/strong>  Malakoplakia is an inflammatory disorder caused by infection and immune dysfunction, most commonly affecting the urinary tract.<\/li>\n<li><strong>What are the main symptoms of malakoplachia?<\/strong> The main symptoms include frequent painful urination, abdominal pain, fever and weight loss.<\/li>\n<li><strong>How is malakoplakia diagnosed?<\/strong> Diagnosis includes laboratory tests, radiological examinations and endoscopic methods.<\/li>\n<li><strong>What is the treatment for malakoplachia?<\/strong> Treatment can be either conservative, using antibiotics and anti-inflammatory drugs, or surgical in the case of granuloma formation.<\/li>\n<li><strong>What are the prognoses and complications of malakoplachia?<\/strong> The prognosis with timely diagnosis and treatment is usually favorable, but complications such as renal failure may develop.<\/li>\n<\/ul>\n<p>This article provides extensive information about malakoplachia and its aspects, aimed at raising awareness among healthcare professionals and patients about this rare disease.<\/p>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Malakoplakia is a rare inflammatory disease characterized by the formation of granulomas and necrotic areas in various organs and tissues, most often in<\/p>","protected":false},"author":1,"featured_media":20654,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-12007","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=12007"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12007\/revisions"}],"predecessor-version":[{"id":15137,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/12007\/revisions\/15137"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/20654"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=12007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=12007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=12007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}