{"id":11931,"date":"2025-06-17T00:57:14","date_gmt":"2025-06-16T22:57:14","guid":{"rendered":"https:\/\/valintermed.com\/?p=11931"},"modified":"2025-06-17T00:57:14","modified_gmt":"2025-06-16T22:57:14","slug":"sindrom-limfedemy-distihiaza","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/","title":{"rendered":"Lymphedema-distichiasis syndrome"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Lymphedema-distichiasis syndrome is a rare genetic disorder characterized by a combination of congenital lymphedema of the lower extremities and distichiasis, a growth abnormality of the eyelashes in which they develop in two rows. The pathology belongs to the group of primary lymphedemas and is part of the spectrum of developmental disorders of the lymphatic system. The disease manifests itself in early childhood and is accompanied by progressive swelling of the extremities of varying severity. Distichiasis can cause irritation of the conjunctiva of the eye and contribute to the development of keratoconjunctivitis. In some cases, a combination of these main signs is observed with other congenital anomalies, such as spina bifida, heart defects, or urological disorders.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of drugs used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/syndrome-of-lymphedema-distichiaza\/#%D0%A1%D0%BE%D0%B2%D0%B5%D1%82%D1%8B_%D0%B4%D0%BE%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D0%9E%D0%BB%D0%B5%D0%B3%D0%B0_%D0%9A%D0%BE%D1%80%D0%B6%D0%B8%D0%BA%D0%BE%D0%B2%D0%B0\" >Advice from Dr. Oleg Korzhikov<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The first description of lymphedema-distichiasis syndrome was presented in the medical literature in 1948 by American dermatologists Fallier and Jones. It is interesting to note that the pathology was initially considered a purely dermatological problem until the genetic mechanisms of the disease were established in the 1960s. \u201cThe discovery of the hereditary nature of the disease was a turning point in understanding its nature,\u201d notes genetics professor Michael Stewart in his 1972 monograph. Of particular historical value are the family studies of the 1980s, which made it possible to trace inheritance patterns through several generations.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The disease has an extremely low prevalence, estimated at approximately 1 case per 4 million population. According to the international rare disease registry Orphanet, there are currently about 200 confirmed cases documented worldwide. According to a study published in the Journal of Medical Genetics (2019), the sex ratio is approximately 1:1, although some authors indicate a slightly higher incidence among women. A higher detection rate is observed in regions with developed rare disease diagnostic systems, such as Scandinavian countries and Japan.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Lymphedema-distichiasis syndrome is inherited in an autosomal dominant manner and is associated with mutations in the FOXC2 gene, located on chromosome 16q24.3. This gene encodes a transcription factor that plays a key role in the development of the lymphatic system and the formation of vascular structures. The main types of mutations include:<\/p>\n<ul>\n<li>Missense mutations<\/li>\n<li>Nonsense mutations<\/li>\n<li>Splicing mutations<\/li>\n<li>Deletions of varying lengths<\/li>\n<\/ul>\n<p>According to a 2021 meta-analysis, the most common mutation is c.1108C&gt;T, found in approximately 35% cases.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The main risk factor is the presence of a mutation in the FOXC2 gene in one of the parents. However, the expression of the disease can be modified by the following factors:<\/p>\n<ul>\n<li>Radiation exposure during pregnancy<\/li>\n<li>Maternal infectious diseases in the first trimester<\/li>\n<li>Contact with teratogenic substances<\/li>\n<li>Associated genetic disorders<\/li>\n<\/ul>\n<p>&quot;It is particularly important to consider the influence of the environment on the phenotypic expression of the mutation,&quot; emphasize the researchers from the Centre for Genetic Research in Copenhagen.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The diagnostic process includes a comprehensive approach:<\/p>\n<ul>\n<li>Clinical examination with assessment of the nature of swelling and condition of the eyelashes<\/li>\n<li>Lymphoscintigraphy to assess the condition of the lymphatic system<\/li>\n<li>MRI of soft tissues<\/li>\n<li>Genetic testing for FOXC2 mutations<\/li>\n<li>Differential diagnosis with other forms of primary lymphedema<\/li>\n<\/ul>\n<p>The table shows the main differential features:<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<p>| Sign | Lymphedema-distichiasis | Simple lymphedema |<br \/>\n|&#8212;&#8212;&#8212;|&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-|&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-|<br \/>\n| Presence of distichiasis | + | \u2014 |<br \/>\n| Age of onset | Early childhood | Any |<br \/>\n| Genetic basis | FOXC2 | Various |<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The therapeutic strategy includes several directions:<\/p>\n<ul>\n<li>Compression therapy with special bandages<\/li>\n<li>Manual lymphatic drainage<\/li>\n<li>Pharmacological therapy with diuretics<\/li>\n<li>Surgical treatment for severe deformities<\/li>\n<li>Correction of distichiasis by electrolysis or cryodestruction<\/li>\n<\/ul>\n<p>\u201cEarly treatment significantly improves the prognosis,\u201d note Mayo Clinic specialists.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of drugs used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li>Furosemide<\/li>\n<li>Spironolactone<\/li>\n<li>Benzopyrone<\/li>\n<li>Acetazolamide<\/li>\n<li>Drugs of the phlebotonic group<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Regular monitoring includes:<\/p>\n<ul>\n<li>Monthly limb circumference monitoring<\/li>\n<li>Quarterly ultrasound of lymphatic vessels<\/li>\n<li>Semi-annual ophthalmological examination<\/li>\n<li>Annual genetic counseling<\/li>\n<\/ul>\n<p>Major complications include the development of cellulitis, trophic ulcers and serious ophthalmological problems.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>In young children, the disease manifests itself mainly as soft edema and requires special attention to compression therapy. In adolescence, symptoms may increase due to hormonal changes. In adult patients, more pronounced changes in the lymphatic system and an increased risk of secondary complications are observed.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>How early can the disease be diagnosed?<\/strong> The first signs usually become noticeable at the age of 2-3 years, but a preliminary diagnosis can be made already at birth.<\/li>\n<li><strong>Is it possible to completely cure the syndrome?<\/strong> A complete cure is impossible, but modern methods allow for effective control of symptoms.<\/li>\n<li><strong>What is the likelihood of transmitting the disease to children?<\/strong> If one parent has the mutation, the risk is approximately 50%.<\/li>\n<li><strong>Does the disease affect life expectancy?<\/strong> With adequate treatment, life expectancy is no different from that of the general population.<\/li>\n<li><strong>What lifestyle restrictions are necessary?<\/strong> It is recommended to avoid injuries to the extremities and prolonged exposure to hot climates.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BE%D0%B2%D0%B5%D1%82%D1%8B_%D0%B4%D0%BE%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D0%9E%D0%BB%D0%B5%D0%B3%D0%B0_%D0%9A%D0%BE%D1%80%D0%B6%D0%B8%D0%BA%D0%BE%D0%B2%D0%B0\"><\/span>Advice from Dr. Oleg Korzhikov<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>&quot;Patients often ask me about the possibility of doing sports with this disease. The answer is simple: many types of physical activity are not only acceptable, but also recommended, especially swimming and yoga. However, it is better to exclude contact sports. Many are also concerned about the possibility of pregnancy - with proper preparation and observation, it is quite possible. I would like to draw special attention to the importance of regular use of compression underwear - this is a basic element of disease control.&quot;<\/p>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Lymphedema-distichiasis syndrome is a rare genetic disorder characterized by a combination of congenital lymphedema of the lower extremities and distichiasis, an abnormality of eyelash growth,<\/p>","protected":false},"author":1,"featured_media":20484,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-11931","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11931","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=11931"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11931\/revisions"}],"predecessor-version":[{"id":15266,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11931\/revisions\/15266"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media\/20484"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=11931"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=11931"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=11931"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}