{"id":11930,"date":"2025-06-17T00:58:20","date_gmt":"2025-06-16T22:58:20","guid":{"rendered":"https:\/\/valintermed.com\/?p=11930"},"modified":"2025-06-17T00:58:20","modified_gmt":"2025-06-16T22:58:20","slug":"sindrom-letalnoy-vrozhdennoy-kontraktury","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/congenital-lethal-contracture-syndrome\/","title":{"rendered":"Lethal congenital contracture syndrome"},"content":{"rendered":"
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Lethal congenital contracture syndrome (LCCS) is an extremely rare autosomal recessive neuromuscular disorder characterized by multiple joint contractures and complete absence of voluntary movements in the fetus. The pathology manifests itself already in the early stages of intrauterine development and leads to intrauterine death of the fetus or death of the newborn in the first hours of life. The clinical picture includes pronounced contractures of the joints of the upper and lower extremities, microcephaly, underdevelopment of the lungs and other severe developmental defects.<\/p>\n

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