{"id":11923,"date":"2025-06-17T04:02:48","date_gmt":"2025-06-17T02:02:48","guid":{"rendered":"https:\/\/valintermed.com\/?p=11923"},"modified":"2025-06-17T04:02:48","modified_gmt":"2025-06-17T02:02:48","slug":"sindrom-lincha","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/lynch-syndrome\/","title":{"rendered":"Lynch syndrome"},"content":{"rendered":"
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Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an autosomal dominant genetic disorder characterized by an increased risk of developing colorectal cancer and other malignancies. It is the most common inherited syndrome associated with colorectal cancer, accounting for approximately 3-5% of all cases of this disease. The pathogenesis of the syndrome is due to mutations in the genes of the DNA mismatch repair system (MMR), which leads to microsatellite instability and an increased frequency of mutations in cells. The clinical picture is characterized by early development of colorectal cancer (usually before the age of 50), predominant localization of tumors in the right half of the colon, and a high risk of developing extra-colorectal malignancies.<\/p>\n

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