{"id":11922,"date":"2025-06-17T04:30:59","date_gmt":"2025-06-17T02:30:59","guid":{"rendered":"https:\/\/valintermed.com\/?p=11922"},"modified":"2025-06-17T04:30:59","modified_gmt":"2025-06-17T02:30:59","slug":"sindrom-liddla","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/liddla-syndrome\/","title":{"rendered":"Liddle's syndrome"},"content":{"rendered":"
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Liddle syndrome is a rare genetic disorder characterized by early-onset hypertension, hypokalemia, and metabolic alkalosis. The pathogenesis of the disease is due to mutations in the genes encoding epithelial sodium channels (ENaC), which leads to excessive sodium reabsorption in the distal nephron and increased sensitivity to mineralocorticoids. First described in the mid-20th century, the disease remains a diagnostic challenge for clinicians.<\/p>\n

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