{"id":11832,"date":"2025-07-25T23:24:18","date_gmt":"2025-07-25T21:24:18","guid":{"rendered":"https:\/\/valintermed.com\/?p=11832"},"modified":"2025-07-25T23:24:18","modified_gmt":"2025-07-25T21:24:18","slug":"defitsit-lizosomalnoy-kisloy-lipazy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/lysosomal-acid-lipase-deficiency\/","title":{"rendered":"Lysosomal acid lipase deficiency"},"content":{"rendered":"
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Lysosomal acid lipase deficiency (LALD) is a rare, inherited metabolic disorder associated with impaired lysosome function. It is caused by a deficiency of the enzyme acid lipase, which is responsible for breaking down triglycerides and cholesterol inside cells. This defect results in the accumulation of lipids, which leads to serious disorders in various organs and systems. Symptoms of the disease may appear in childhood or remain hidden until later in life, which complicates diagnosis. The clinical spectrum of LALD manifestations varies from asymptomatic to severe forms with progressive dysfunction of the liver, cardiovascular system, and other organs. Treatment of this disease currently includes both pharmacological and potentially surgical components.<\/p>\n

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