{"id":11829,"date":"2025-07-25T23:25:54","date_gmt":"2025-07-25T21:25:54","guid":{"rendered":"https:\/\/valintermed.com\/?p=11829"},"modified":"2025-07-25T23:25:54","modified_gmt":"2025-07-25T21:25:54","slug":"defitsit-adgezii-leykotsitov-tip-1","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/lack-of-adgezii-leykotsitov-tip-1\/","title":{"rendered":"Leukocyte adhesion deficiency type 1"},"content":{"rendered":"
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Leukocyte adhesion deficiency type 1 (LAD-1) is a rare inherited disorder characterized by impaired ability of leukocytes (white blood cells) to adhere to vascular endothelium and migrate to sites of inflammation. This condition is caused by deficiency or absence of integrins, which are necessary for leukocyte adhesion. As a result, patients with LAD-1 experience frequent bacterial infections, which can lead to severe complications and, in some cases, death. Limited ability to biocenosis and protection against infections significantly reduces the quality of life of such patients, which requires a comprehensive approach to diagnosis and treatment.<\/p>\n

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