{"id":11671,"date":"2025-07-26T07:25:41","date_gmt":"2025-07-26T05:25:41","guid":{"rendered":"https:\/\/valintermed.com\/?p=11671"},"modified":"2025-07-26T07:25:41","modified_gmt":"2025-07-26T05:25:41","slug":"bolezn-krabbe","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/krabbe-s-disease\/","title":{"rendered":"Krabbe disease"},"content":{"rendered":"
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Krabbe disease (global leukodystrophy) is a rare, inherited neurodegenerative disorder caused by a deficiency of the enzyme galactosylceramidase. This leads to an accumulation of galactosylceramide in cells of the nervous system, which in turn causes damage to the myelin sheath of nerve fibers. The disease manifests itself in early childhood, often in the first six months of life, and is characterized by a rapidly declining spectrum of neurological symptoms, including progressive weakness, deterioration of muscle tone, seizures, and neurological deficits. The prognosis for patients with this disease is generally poor, as most patients die in childhood or young adulthood.<\/p>\n

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