{"id":11643,"date":"2025-07-26T08:54:26","date_gmt":"2025-07-26T06:54:26","guid":{"rendered":"https:\/\/valintermed.com\/?p=11643"},"modified":"2025-07-26T08:54:26","modified_gmt":"2025-07-26T06:54:26","slug":"sindrom-holta-orama","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/holt-s-syndrome\/","title":{"rendered":"Holt-Oram syndrome"},"content":{"rendered":"
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Holt-Oram syndrome is a hereditary disorder that belongs to a group of genetic developmental defects characterized by abnormalities in the formation of the cardiovascular system and skeleton. This disease is caused by mutations in genes responsible for the development of the heart and blood vessels, which leads to abnormalities in the structure of the heart, such as atrial and ventricular septal defects, as well as abnormalities of the limbs and chest. The syndrome has an autosomal dominant type of inheritance, which means that the disease can be passed from one parent to children with a probability of 50%. Symptoms of the disease vary from mild forms with minimal manifestations to severe forms with life-threatening cardiac abnormalities.<\/p>\n

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