{"id":11610,"date":"2025-07-26T10:26:28","date_gmt":"2025-07-26T08:26:28","guid":{"rendered":"https:\/\/valintermed.com\/?p=11610"},"modified":"2025-07-26T10:26:28","modified_gmt":"2025-07-26T08:26:28","slug":"nasledstvennyy-sindrom-paragangliomy-feohromotsitomy","status":"publish","type":"post","link":"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/","title":{"rendered":"Hereditary paraganglioma-pheochromocytoma syndrome"},"content":{"rendered":"<div class=\"fpm_start\"><\/div>\n<p>Paragangliomas and pheochromocytomas are rare tumors that arise from chromaffin cells, which are responsible for the synthesis and release of catecholamines such as epinephrine and norepinephrine. These tumors can develop in a variety of locations, including the adrenal glands and in the paraganglia located along the sympathetic nervous system. Hereditary paraganglioma-pheochromocytoma syndrome is a genetic predisposition to develop these tumors and is associated with various genetic mutations that result in an increased risk of their occurrence. This syndrome can present as multiple tumors, which greatly complicates the clinical picture and requires careful monitoring and diagnosis.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_86 counter-flat ez-toc-counter ez-toc-light-blue ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Content<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewbox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" 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href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\" >History of the disease and interesting historical facts<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\" >Epidemiology<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\" >Genetic predisposition to this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Risk factors for the development of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Diagnosis of this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\" >Treatment<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >List of medications used to treat this disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Disease monitoring<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\" >Age-related features of the disease<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\" >Questions and Answers<\/a><\/li><li class='ez-toc-page-1'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/valintermed.com\/en\/medlibrary\/hereditary-paragangliomatosis-syndrome\/#%D0%A1%D0%BE%D0%B2%D0%B5%D1%82%D1%8B_%D0%BE%D1%82_%D0%B4%D0%BE%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D0%9E%D0%BB%D0%B5%D0%B3%D0%B0_%D0%9A%D0%BE%D1%80%D0%B6%D0%B8%D0%BA%D0%BE%D0%B2%D0%B0\" >Advice from Dr. Oleg Korzhikov<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"%D0%98%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%8F_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F_%D0%B8_%D0%B8%D0%BD%D1%82%D0%B5%D1%80%D0%B5%D1%81%D0%BD%D1%8B%D0%B5_%D0%B8%D1%81%D1%82%D0%BE%D1%80%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B8%D0%B5_%D1%84%D0%B0%D0%BA%D1%82%D1%8B\"><\/span>History of the disease and interesting historical facts<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Paragangliomas and pheochromocytomas were first described in the medical literature in the late 19th century. In 1886, German pathologist Rudolf Virchow presented his findings on tumors arising from nervous tissue that were later identified as paragangliomas. In the mid-20th century, it was recognized that these tumors may be hereditary, leading to modern research focusing on identifying the genetic mutations associated with the syndrome. There are known cases of multiple cases of pheochromocytoma in a single family, supporting the hereditary nature of the disease. For example, one of the first major studies in the 1970s demonstrated an association between pheochromocytomas and rare genetic syndromes such as multiple endocrine neoplasia.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%AD%D0%BF%D0%B8%D0%B4%D0%B5%D0%BC%D0%B8%D0%BE%D0%BB%D0%BE%D0%B3%D0%B8%D1%8F\"><\/span>Epidemiology<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The epidemiology of paragangliomas and pheochromocytomas is characterized by their rarity. According to statistics, 1-3 cases of pheochromocytoma are registered per 100,000 people worldwide. One of the most significant features is the different prevalence of these tumors in different population groups. In men and women, the incidence ratio is approximately 1:1, but in women, the disease may manifest itself at a later age. <\/p>\n<p>Research shows that more than 30% cases are hereditary, making proper diagnosis and monitoring especially important. In addition, there is evidence that pheochromocytomas are more common in patients with certain syndromes, such as Neif-Zollinger syndrome and Li-Fraumeni syndrome.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%93%D0%B5%D0%BD%D0%B5%D1%82%D0%B8%D1%87%D0%B5%D1%81%D0%BA%D0%B0%D1%8F_%D0%BF%D1%80%D0%B5%D0%B4%D1%80%D0%B0%D1%81%D0%BF%D0%BE%D0%BB%D0%BE%D0%B6%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D1%8C_%D0%BA_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%BC%D1%83_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8E\"><\/span>Genetic predisposition to this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Genetic predisposition to hereditary paraganglioma-pheochromocytoma syndrome is associated with changes in several key genes. The major genes involved include:<\/p>\n<ul>\n<li><strong>SDHB<\/strong> \u2014 mutations in this gene are associated with poor production of succinate dehydrogenase and an increased risk of pheochromocytoma and paraganglioma.<\/li>\n<li><strong>SDHD<\/strong> - changes in this gene can also lead to hereditary tumors in combination with other genetic mutations.<\/li>\n<li><strong>RET<\/strong> \u2014 mutations in this gene are associated with hereditary multiple endocrine neoplasia type 2.<\/li>\n<li><strong>VHL<\/strong> \u2014 associated with von Hippel-Lindau syndrome, which may include pheochromocytomas as one of its manifestations.<\/li>\n<\/ul>\n<p>Mutations in these genes can also lead to the development of other diseases, making genetic testing essential for diagnosis and monitoring of patients. Modern genetic predisposition tests can help identify familial cases and early detection of diseases in family members.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A4%D0%B0%D0%BA%D1%82%D0%BE%D1%80%D1%8B_%D1%80%D0%B8%D1%81%D0%BA%D0%B0_%D0%B2%D0%BE%D0%B7%D0%BD%D0%B8%D0%BA%D0%BD%D0%BE%D0%B2%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Risk factors for the development of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Identification of risk factors plays an important role in the prognosis and treatment of paragangliomas and pheochromocytomas. The main physical and chemical risk factors include:<\/p>\n<ul>\n<li>Heredity - having a history of the disease in your family significantly increases your risk.<\/li>\n<li>Radiation exposure - Previous radiation treatments to the head and neck area may increase the chance of developing tumors.<\/li>\n<li>Chemical carcinogens such as benzene and some industrial exposures are also associated with increased risk.<\/li>\n<\/ul>\n<p>In addition to these factors, there are other possible associated conditions such as metabolic disorders that may affect catecholamine levels and lead to tumor development.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%94%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8%D0%BA%D0%B0_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Diagnosis of this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Diagnosis of paragangliomas and pheochromocytomas includes several stages and methods, starting with a clinical examination and ending with laboratory and instrumental studies.<\/p><script data-noptimize=\"\" data-wpfc-render=\"false\">\nfpm_start( \"true\" );\n<\/script>\n\n<ul>\n<li><strong>Main symptoms<\/strong> may include headaches, hypertension, sweating, pressure surges and tachycardia, which is associated with increased levels of catecholamines.<\/li>\n<li><strong>Laboratory research<\/strong> include determination of levels of metanephrines and normetanephrines in plasma and urine, which makes it possible to establish a diagnosis.<\/li>\n<li><strong>Radiological examinations<\/strong> include computed tomography (CT) scans and magnetic resonance imaging (MRI), which help visualize tumors and determine their size and location.<\/li>\n<li><strong>Other types of diagnostics<\/strong> may include scintigraphy, which uses radioactive substances to better visualize tumors.<\/li>\n<li><strong>Differential diagnosis<\/strong> is critically important because the symptoms of pheochromocytoma may overlap with other diseases such as thyrotoxicosis or pancreatitis.<\/li>\n<\/ul>\n<p>A well-organized diagnostic study allows not only to confirm the presence of a tumor, but also to take into account concomitant conditions and possible genetic predispositions.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9B%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D0%B5\"><\/span>Treatment<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Treatment of patients with paragangliomas and pheochromocytomas requires a multi-level approach that includes both general therapeutic strategies and specialized methods.<\/p>\n<ul>\n<li><strong>General treatment<\/strong> involves controlling blood pressure and symptoms, often with alpha-blockers.<\/li>\n<li><strong>Pharmacological treatment<\/strong> may include the use of beta blockers and other classes of drugs to manage symptoms and control metabolism.<\/li>\n<li><strong>Surgical treatment<\/strong> is the main method for localized tumors, requiring a carefully planned surgical intervention.<\/li>\n<li><strong>Other types of treatment<\/strong> may include radiotherapy and targeted therapy in case of recurrence or metastasis.<\/li>\n<\/ul>\n<p>The choice of treatment method depends on many factors, including the size and location of the tumor, as well as the presence of metastases and the hemodynamic state of the patient.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BF%D0%B8%D1%81%D0%BE%D0%BA_%D0%BB%D0%B5%D0%BA%D0%B0%D1%80%D1%81%D1%82%D0%B2_%D0%BF%D1%80%D0%B8%D0%BC%D0%B5%D0%BD%D1%8F%D0%B5%D0%BC%D1%8B%D1%85_%D0%B4%D0%BB%D1%8F_%D0%BB%D0%B5%D1%87%D0%B5%D0%BD%D0%B8%D1%8F_%D0%B4%D0%B0%D0%BD%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>List of medications used to treat this disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The list of drugs that can be used in the treatment of paragangliomas and pheochromocytomas includes:<\/p>\n<ul>\n<li>Alpha-blockers (eg, prazosin)<\/li>\n<li>Beta blockers (eg, atazanavir)<\/li>\n<li>Antihypertensive drugs (eg, amlodipine)<\/li>\n<li>Chemotherapy drugs for targeted therapy (eg, metformin for concomitant metabolic disorders)<\/li>\n<\/ul>\n<p>Treatment should be carried out under strict medical supervision, taking into account the individual characteristics of the patient and the response to therapy.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%9C%D0%BE%D0%BD%D0%B8%D1%82%D0%BE%D1%80%D0%B8%D0%BD%D0%B3_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Disease monitoring<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Monitoring of patients with paragangliomas and pheochromocytomas is an important part of their treatment and includes:<\/p>\n<ul>\n<li><strong>Control stages<\/strong> - regular medical examinations, including laboratory and radiological studies, to detect relapses and disease progression.<\/li>\n<li><strong>Forecast<\/strong> depends on many factors, including the stage at diagnosis, the time of treatment initiation, and individual genetic mutations.<\/li>\n<li><strong>Complications<\/strong> may include metastatic tumors, cardiovascular disease, and the development of secondary tumors.<\/li>\n<\/ul>\n<p>Proper monitoring and early diagnosis of complications significantly improve the prognosis for patients with this disease.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%B7%D1%80%D0%B0%D1%81%D1%82%D0%BD%D1%8B%D0%B5_%D0%BE%D1%81%D0%BE%D0%B1%D0%B5%D0%BD%D0%BD%D0%BE%D1%81%D1%82%D0%B8_%D0%B7%D0%B0%D0%B1%D0%BE%D0%BB%D0%B5%D0%B2%D0%B0%D0%BD%D0%B8%D1%8F\"><\/span>Age-related features of the disease<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Paragangliomas and pheochromocytomas can occur at any age, but age-related features include:<\/p>\n<ul>\n<li><strong>Children<\/strong> \u2014 in children, these tumors are more often associated with hereditary syndromes and may appear at an earlier age.<\/li>\n<li><strong>Young people (under 30 years old)<\/strong> - high risk of hereditary factors.<\/li>\n<li><strong>Middle aged people<\/strong> \u2014 spontaneous cases of the disease are observed more often.<\/li>\n<li><strong>Elderly patients<\/strong> \u2014 tumors may have a more aggressive course and be associated with a higher frequency of concomitant diseases.<\/li>\n<\/ul>\n<p>The peculiarities of the course of the disease in different age groups require an individual approach to diagnosis and treatment.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"%D0%92%D0%BE%D0%BF%D1%80%D0%BE%D1%81%D1%8B_%D0%B8_%D0%BE%D1%82%D0%B2%D0%B5%D1%82%D1%8B\"><\/span>Questions and Answers<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<ul>\n<li><strong>What is the likelihood of inheriting paraganglioma-pheochromocytoma syndrome?<\/strong>  The probability of inheritance is approximately 30-50% in close relatives of the patient.<\/li>\n<li><strong>How often do relapses occur after treatment?<\/strong> Recurrences may occur in 10-20% cases, so long-term monitoring is necessary.<\/li>\n<li><strong>Is it possible to prevent the development of tumors if there is a hereditary predisposition?<\/strong> There is no direct prevention, but regular medical examinations can greatly assist in early detection.<\/li>\n<li><strong>What are the main symptoms of paraganglioma-pheochromocytoma?<\/strong> The main symptoms include high blood pressure, headaches, profuse sweating and emotional instability.<\/li>\n<\/ul>\n<h2><span class=\"ez-toc-section\" id=\"%D0%A1%D0%BE%D0%B2%D0%B5%D1%82%D1%8B_%D0%BE%D1%82_%D0%B4%D0%BE%D0%BA%D1%82%D0%BE%D1%80%D0%B0_%D0%9E%D0%BB%D0%B5%D0%B3%D0%B0_%D0%9A%D0%BE%D1%80%D0%B6%D0%B8%D0%BA%D0%BE%D0%B2%D0%B0\"><\/span>Advice from Dr. Oleg Korzhikov<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>According to Dr. Oleg Korzhikov, it is important to remember the need for regular blood pressure monitoring in people with a hereditary predisposition to paragangliomas. Even if you have no symptoms, early diagnosis can save your life. In addition, he advises avoiding exposure to aggressive chemicals and radiation, which can reduce the risk of tumor development. Support from loved ones in therapy and psychological adaptation also plays a key role. Do not forget that following all doctor&#039;s recommendations and regular examinations can significantly improve the quality of life and the patient&#039;s life in general.<\/p>\n<div class=\"fpm_end\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Paragangliomas and pheochromocytomas are rare tumors that arise from chromaffin cells, which are responsible for the synthesis and release of catecholamines such as<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[298],"tags":[],"class_list":["post-11610","post","type-post","status-publish","format-standard","hentry","category-medlibrary"],"_links":{"self":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/comments?post=11610"}],"version-history":[{"count":1,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11610\/revisions"}],"predecessor-version":[{"id":15605,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/posts\/11610\/revisions\/15605"}],"wp:attachment":[{"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/media?parent=11610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/categories?post=11610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/valintermed.com\/en\/wp-json\/wp\/v2\/tags?post=11610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}